전이 눈꺼풀 병변으로 진단된 원발유방암 1예
Eyelid Mass as Initial Presentation of Breast Cancer: A Case Report
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목적: 눈꺼풀의 종괴를 주소로 내원한 환자에서 조직검사를 시행하여 원발유방암을 진단한 사례를 경험하였기에 이를 보고하고자 한다. 증례요약: 41세 여자 환자가 한 달 전부터 발생한 왼쪽 아래눈꺼풀의 통증을 동반한 종괴를 주소로 내원하였다. 좌안 가쪽 아래 눈꺼풀판결막에서도 분홍색의 덩어리가 발견되었으며 안와 컴퓨터 단층촬영에서 눈물샘과 이어지는 왼쪽 아래눈꺼풀에 경계가 불분명한 종괴 소견을 보였다. 좌안 눈꺼풀판결막에서 결막 덩어리의 생검을 시행하였으며 조직검사에서 악성 상피성 종양, 특히 유방 기원의 전이암일 가능성이 높다는 결과를 받았다. 유방외과에서 협진 진료를 시행하였으며 양측 유방의 침윤성 관상피암을 진단 받고 현재 항암치료를 시행하는 중이다. 결론: 눈꺼풀의 전이암은 매우 드물고 전체 악성 눈꺼풀 병변의 1% 이내를 차지한다. 눈꺼풀의 종괴를 주소로 내원한 환자에서 원발암을 진단한 사례를 경험하여 이에 대하여 보고하고자 한다.
Abstract
Purpose: We report a case in which eyelid mass was the initial presentation of breast cancer. The diagnosis of breast cancer was made after lid biopsy. Case summary: A 41-year-old female patient presented with a painful mass on the left lower lid after 1 month. There was a pinkish mass in the lateral portion of the tarsal conjunctiva, and computed tomography revealed a mass with an irregular margin on the lower lid connected to the left lacrimal gland. Biopsy was performed at the tarsal conjunctiva of the left eye, and histopathologic examination was suggestive of malignant epithelial cell neoplasm, especially metastatic carcinoma in the breast. The patient was diagnosed as having invasive ductal cancer, for which she is currently receiving chemotherapy. Conclusions: Metastases to the eyelid are very rare, accounting for less than 1% of all malignant eyelid lesions. We report a patient who presented with an eyelid mass as the initial presentation of breast cancer, which was diagnosed with metastatic breast cancer.
참고문헌 (15)
- Fonseca NL Jr, "Metastatic eyelid disease associated with primary breast carcinoma: case report", Arq Bras Oftalmol, 72, pp.390~393 (2009)
- Goldberg RA, "Clinical characteristics of metastatic orbital tumors", Ophthalmology, 97, pp.620~624 (1990)
- Bianciotto C, "Metastatic tumors to the eyelid: report of 20 cases and review of the literature", Arch Ophthalmol, 127, pp.999~1005 (2009)
- Shields JA, "Survey of 1264 patients with orbital tumors and simulating lesions: The 2002 Montgomery Lecture, part 1", Ophthalmology, 111, pp.997~1008 (2004)
- Tomizawa Y, "Orbital metastasis as the initial presentation of invasive lobular carcinoma of breast", Intern Med, 51, pp.1635~1638 (2012)
- Cook BE Jr, "Epidemiologic characteristics and clinical course of patients with malignant eyelid tumors in an incidence cohort in Olmsted County, Minnesota", Ophthalmology, 106, pp.746~750 (1999)
- 박하나, "한국인 눈꺼풀 악성종양의 임상 양상", 대한안과학회지, 55(3), pp.348~353 (2014), 대한안과학회
- Tamura M, "Clinical study on the metastasis to the eyes from breast cancer", Breast Cancer, 11, pp.65~68 (2004)
- Rubio FA, "Eyelid metastasis as the presenting sign of recurrent carcinoma of the breast", Br J Dermatol, 137, pp.1026~1027 (1997)
- Mansour AM, "Metastatic eyelid disease", Ophthalmology, 94, pp.667~670 (1987)
- Ferry AP, "Carcinoma metastatic to the eye and orbit. I. A clinicopathologic study of 227 cases", Arch Ophthalmol, 92, pp.276~286 (1974)
- Kiely BE, "How long have I got? Estimating typical, best-case, and worst-case scenarios for patients starting first-line chemotherapy for metastatic breast cancer:a systematic review of recent randomized trials", J Clin Oncol, 29, pp.456~463 (2011)
- Zhang GJ, "Eyelid metastasis from breast cancer showing marked response to chemotherapy", Jpn J Clin Oncol, 25, pp.10~15 (1995)
- 정재욱, "유방암 전이에 의한 압박 시신경병증 1예", 대한안과학회지, 51(8), pp.1161~1165 (2010), 대한안과학회
- Kim HJ, "Two cases of metastatic breast cancer to the choroid", J Korean Ophthalmol Soc, 31, pp.984~987 (1990)