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급성 폐쇄각녹내장 환자에서 치료와 예방목적으로 시행한 레이저홍채절개술 후 전안부 변화

Anterior Segment Changes after Laser Iridotomy for the Treatment and Prevention of Angle-closure Glaucoma

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목적: 급성 폐쇄각녹내장이 발생한 환자에서 녹내장이 발생한 눈에 치료적 목적으로 레이저홍채절개술을 시행하였을 때와 반대쪽에 예방적으로 레이저홍채절개술을 시행하였을 때 두 눈의 특성과 전안부 변화를 비교해 보고자 한다. 대상과 방법: 급성 폐쇄각녹내장이 발생한 20안(치료군)과 얕은 전방을 보이는 반대편 눈 20안(예방군)을 대상으로 레이저홍채절개술 시행 전과 시행 1개월 후, 그리고 3개월 후에 각막 지형도, 레이저 빛간섭계, 전안부 빛간섭 단층 촬영을 사용하여 전안부 검사를 시행하였다. 각 군의 전방 깊이, 전방 부피, 전방각, 전방각간거리 500, 전방각간거리 750, 각막 곡률, 안축장, 중심 각막 두께를 레이저 시술 전후로 비교하였다. 결과: 레이저 시행 전 예방군과 치료군을 비교했을 때 중심 각막 두께와 전방 깊이를 제외한 나머지 계측치는 통계학적으로 유의한 차이를 보이지 않았다. 레이저 시행 전과 시행 1개월 후, 레이저 시행 전과 3개월 후를 비교했을 때 두 군 모두 전방 부피, 전방각, 전방각간거리 500, 전방각간거리 750이 증가하였다. 그리고 레이저 1개월 후 예방군과 치료군을 비교하였을 때 치료군에서 전방각간거리 750이 더 컸고, 레이저 3개월 후에는 예방군과 치료군의 전안부 계측치에서 통계학적으로 유의한 차이를 보이지 않았다. 결론: 레이저 주변부 홍채 절개술 시행 전 급성 폐쇄각녹내장이 발생한 눈과 반대쪽 눈은 중심 각막 두께와 전방 깊이를 제외하고 구조적으로 큰 차이가 없음을 확인하였고, 레이저홍채절개술 후 전안부 구조의 변화는 치료군에서 더 크며, 열린 전방각은 1개월 후면 큰 변화 없이 유지되는 것을 확인할 수 있었다.

Abstract

Purpose: To evaluate the changes and characteristics of the anterior segment of the eye after laser peripheral iridotomy (LPI) conducted on patients with acute angle closure crisis (AACC) for both therapeutic purposes and prophylactic purposes in the fellow eye. Methods: Anterior segments were examined by topography, laser interferometry, anterior segment optical coherence tomography, anterior chamber depth (ACD), anterior chamber volume (ACV), anterior chamber angle (ACA), angle opening distance (AOD), central corneal thickness (CCT), and axial length as compared to prior procedures in 20 eyes with glaucoma (treatment group) and 20 contralateral eyes (prophylactic group) in 20 patients diagnosed with AACC. Results: Before laser treatment, there were no significant differences in pre-LPI ACV, ACA, AOD and axial length, although differences in the CCT and ACD existed between the groups. Compared to prior laser treatment at 1 and 3 months after laser treatment, the ACV, ACA, AOD 500, and AOD 750 increased in both groups. When both groups were compared 1 month after their laser treatments, the AOD 750 was increased in the treatment group. There were no significant differences between two groups 3 months post LPI. Conclusions: Other than changes in the ACD and CCT, no significant differences were observed in the anterior segment characteristics in AACC affected and contralateral eyes prior to LPI. After LPI, the treatment group showed greater changes in their anterior segments; however, the open angle was maintained at 1 month post treatment.

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