갑상선 이상과 건성안의 관계: 제5기 국민건강영양조사 자료
Thyroid Abnormality and Dry Eye Syndrome: a Cross-sectional Study from the Republic of Korea
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목적: 한국 성인에서 갑상선 이상과 건성안의 관계를 밝히고자 하였다. 대상과 방법: 제5기 국민건강영양조사(2012) 자료를 이용하여 건성안 검진을 받은 총 16,966명을 대상으로 갑상선 이상과 건성안의 연관성을 다변량 로지스틱 회귀분석을 이용해 분석하였다. 결과: 대조군과 비교하였을 때, 건성안군에서 여성, 도시지역 거주 비율이 높았고, 소득수준이 낮았으며, 비흡연자, 비음주자 비율이 높았고, 체질량지수가 낮았으며, 고혈압, 고지혈증, 갑상선 이상, 갑상선질환, 갑상선암 유병률이 높았다. 유의한 모든 변수를 포함한 다변량 로지스틱 회귀분석 결과상 갑상선 이상(odds ratio [OR], 1.93; 95% confidence interval [CI], 1.43-2.61), 갑상선질환(OR, 1.85; 95% CI, 1.37-2.52), 갑상선암(OR, 2.45; 95% CI, 1.06-5.67)이 모두 건성안과 유의한 연관성을 보였다. 또한 성별로는 여성에서갑상선 이상(OR, 2.02; 95% CI, 1.47-2.76), 갑상선질환(OR, 1.93; 95% CI, 1.41-2.65), 갑상선암(OR, 2.62; 95% CI, 1.06-6.62)이 건성안과 유의한 연관성을 보였으나, 남성에서는 이러한 연관성이 유의하지 않았다. 결론: 갑상선 이상, 갑상선질환, 갑상선암은 건성안의 위험인자로 고려될 수 있으며, 특히 여성환자 진찰 시 갑상선 이상에 대해 더 주의 깊은 관찰 및 평가가 필요할 것으로 생각된다.
Abstract
Purpose: To investigate the relationship between thyroid abnormality and dry eye syndrome (DES) in a nationally representative Korean population. Methods: A population-based prospective cross-sectional study was conducted, using the thyroid abnormality data set of the Korean National Health and Nutrition Examination Survey, 2010 - 2012. A total of 16,966 Korean participants with DES were enrolled in the study. Results: The DES patients were predominantly women, non-smokers and non-drinkers, living in urban regions, with a low income and body mass index (BMI), and with a higher percentage of hypertension, hyperlipidemia, thyroid abnormalities, thyroid diseases, and thyroid cancers. After adjusting for all significant variables, thyroid abnormality (odds ratio [OR], 1.93; 95% confidence interval [CI], 1.43-2.61), thyroid disease (OR, 1.85; 95% CI, 1.37-2.52), and thyroid cancer (OR, 2.45; 95% CI, 1.06-5.67) were significantly associated with DES. There was also a significant association between DES and thyroid abnormalities (OR, 2.02; 95% CI, 1.47-2.76), thyroid diseases (OR, 1.93; 95% CI, 1.41-2.65), and thyroid cancer (OR, 2.62; 95% CI, 1.06-6.62) in the female group, but there was no significant association in the male group. Conclusions: Thyroid abnormalities, thyroid diseases, and thyroid cancers were associated with DES in a nationally representative Korean population. Close evaluation of thyroid abnormalities is therefore needed when treating female patients.
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