빛간섭단층혈관조영술로 확인한 백내장수술 전후 망막중심오목 무혈관부위와 망막혈관밀도의 변화
Impact of Cataract Surgery on Foveal Avascular Zone Detected by Optical Coherence Tomography Angiography
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
목적: 백내장수술 전후 망막중심오목 무혈관부위 및 망막혈관밀도의 변화를 빛간섭단층혈관조영술을 통해 확인하고자 한다. 대상과 방법: 백내장수술을 받은 64명의 환자의 64안을 대상으로 수술 전과 후 두 가지 종류의 빛간섭단층혈관조영술이 시행되었다. 백내장수술 전후의 망막중심오목 무혈관부위 크기와 망막모세혈관밀도를 대응표본 t-검정을 통해 비교하였다. 결과: Cirrus Angioplex 빛간섭단층혈관조영술을 이용하여 비교한 백내장수술 전과 후의 망막중심오목 무혈관부위의 크기(p=0.060), 둘레(p=0.052), 진원도(p=0.190)는 의미 있는 차이를 보이지 않았다. Spectralis 빛간섭단층혈관조영술을 사용한 검사시에도 백내장수술 전후 망막중심오목 무혈관부위의 크기(p=0.239) 차이가 없었다. Cirrus Angioplex 빛간섭단층혈관조영술을 이용하여 확인한 중심(p=0.310), 내부(p=0.310), 외부(p=0.310) 그리고 전체(p=0.228) 망막모세혈관밀도는 차이를 보이지 않았다. 결론: 백내장 유무는 빛간섭단층혈관조영술을 이용한 망막중심오목 무혈관부위 확인에 영향을 미치지 않음을 확인하였다. 따라서, 망막중심오목 무혈관부위와 관련을 보이는 것으로 알려진 당뇨망막병증 등으로 정기적인 검사를 받는 환자에서 백내장수술을 진행하게 되더라도 수술 후 얻은 결과가 신뢰할 수 있으며 수술 전 검사와도 비교할 수 있는 결과임을 확인할 수 있었다.
Abstract
Purpose: To investigate the influence of cataract surgery on detection of a foveal avascular zone (FAZ) and retinal capillary density (RCD) by optical coherence tomography angiography (OCTA). Methods: In this study, 64 eyes of 64 patients with cataracts who underwent surgery were included and studied retrospectively. All patients underwent cataract surgery of the included eye and a FAZ was detected on OCTA preoperatively and postoperatively using one of two kinds of OCTA devices. The FAZ and RCD were compared before and after cataract surgery using paired t-test. Results: Using the Cirrus Angioplex OCTA device, there was no significant pre- or post-operative difference in the FAZ area (p = 0.060), perimeter (p = 0.052) and circularity (p = 0.190). It also revealed no significant difference between the central (p = 0.310), inner (p = 0.310), and outer (p = 0.310) zones and full RCD (p = 0.228) before and after cataract surgery The Spectralis OCTA device also showed no significant difference in the FAZ area (p = 0.239) before and after cataract surgery. Conclusions: Cataract surgery does not affect detection of the FAZ and RCD on OCTA. Although patients who have a FAZ-related retinal disorder such as diabetic retinopathy and undergo cataract surgery are followed up regularly, it seems that the results gained by OCTA are reliable and comparable to the preoperative result.
참고문헌 (20)
- Conrath J, "Foveal avascular zone in diabetic retinopathy : quantitative vs qualitative assessment", Eye(Lond), 19, pp.322~326 (2005)
- Samara WA, "Correlation of foveal avascular zone size with foveal morphology in normal eyes using optical coherence tomography angiography", Retina, 35, pp.2188~2195 (2015)
- Takase N, "Enlargement of foveal avascular zone in diabetic eyes evaluated by en face optical coherence tomography angiography", Retina, 35, pp.2377~2383 (2015)
- Wu LZ, "Characteristics of the capillary-free zone in the normal human macula", Jpn J Ophthalmol, 29, pp.406~411 (1985)
- Yu J, "Macular perfusion in healthy Chinese : an optical coherence tomography angiogram study", Invest Ophthalmol Vis Sci, 56, pp.3212~3217 (2015)
- Chan G, "Quantitative changes in perifoveal capillary networks in patients with vascular comorbidities", Invest Ophthalmol Vis Sci, 54, pp.5175~5185 (2013)
- Jonas JB, "Count and density of human retinal photoreceptors", Graefes Arch Clin Exp Ophthalmol, 230, pp.505~510 (1992)
- Samara WA, "Quantitative optical coherence tomography angiography features and visual function in eyes with branch retinal vein occlusion", Am J Ophthalmol, 166, pp.76~83 (2016)
- Casselholmde SM, "Optical coherence tomography angiography in central retinal vein occlusion : correlation between the foveal avascular zone and visual acuity", Invest Ophthalmol Vis Sci, 57, pp.242~246 (2016)
- Balaratnasingam C, "Visual acuity is correlated with the area of the foveal avascular zone in diabetic retinopathy and retinal vein occlusion", Ophthalmology, 123, pp.2352~2367 (2016)
- Shahlaee A, "In vivo assessment of macular vascular density in healthy human eyes using optical coherence tomography angiography", Am J Ophthalmol, 165, pp.39~46 (2016)
- Carpineto P, "Reproducibility and repeatability of foveal avascular zone measurements in healthy subjects by optical coherence tomography angiography", Br J Ophthalmol, 100, pp.671~676 (2016)
- Fleiss JL, "Statistical methods for rates and proportions", pp.604~ (2003), Wiley-Interscience
- Nobre CJ, "Systematic evaluation of optical coherence tomography angiography in retinal vein occlusion", Am J Ophthalmol, 163, pp.93~107.e6 (2016)
- Cho JH, "Foveal microvasculature features of surgically closed macular hole using optical coherence tomography angiography", BMC Ophthalmol, 17, pp.217~ (2017)
- Kim YJ, "Macular capillary plexuses after macular hole surgery : an optical coherence tomography angiography study", Br J Ophthalmol, 102, pp.966~970 (2018)
- Kita Y, "Changes in the size of the foveal avascular zone after vitrectomy with internal limiting membrane peeling for a macular hole", Jpn J Ophthalmol, 61, pp.465~471 (2017)
- Kim YJ, "Macular capillary plexuses after epiretinal membrane surgery : an optical coherence tomography angiography study", Br J Ophthalmol, 102, pp.1086~1091 (2018)
- Yu S, "Cataract significantly influences quantitative measurements on swept-source optical coherence tomography angiography imaging", PLoS One, 13, pp.e0204501~ (2018)
- Zhao Z, "Changes in macular vasculature after uncomplicated phacoemulsification surgery : optical coherence tomography angiography study", J Cataract Refract Surg, 44, pp.453~458 (2018)