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두충 추출물 투여와 트레드밀 운동이 골다공증 유발 백서의 골대사에 미치는 영향

Effects of Eucommia Ulmoides Oliver and Treadmill Exercise on the Osteoporosis of Rats Caused by Glucocorticoid Induction

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초록

This study classified 40 of 10 weeks-old male Sprague Dawley rats which have osteoporosis caused by glucocorticoid(GC) induction into four groups of 10 rats and made the subjects medicated them Eucommia ulmoides Oliver and participate in treadmill exercise. Group Ⅰ was non-treatment after GC induction; Group Ⅱ was treadmill exercise after GC induction; Group Ⅲ was Eucommia ulmoides Oliver feeding after GC induction; Group Ⅳ was treadmill exercise and Eucommia ulmoides Oliver feeding after GC induction. In the bone mineral density and bone strength test, there was a statistically significant difference between the group Ⅰ, Ⅱ, Ⅲ compared to group Ⅳ(p<0.05). In the osteocalcin level as one of bone formation indexes, there was a statistically significant difference between the group Ⅰ, Ⅱ, Ⅲ compared to group Ⅳ(p<0.05). In respect to the calcium there was a statistically significant difference between group Ⅰ, Ⅱ, Ⅲ compared to group Ⅳ(p<0.05). In respect to histological findings, the group Ⅳ showed mild femur disruption and lytic change on femur section. The above results suggests that Eucommia ulmoides Oliver medicated and treadmill exercise is effective to prevention and treatment of osteoporosis.

Abstract

This study classified 40 of 10 weeks-old male Sprague Dawley rats which have osteoporosis caused by glucocorticoid(GC) induction into four groups of 10 rats and made the subjects medicated them Eucommia ulmoides Oliver and participate in treadmill exercise. Group Ⅰ was non-treatment after GC induction; Group Ⅱ was treadmill exercise after GC induction; Group Ⅲ was Eucommia ulmoides Oliver feeding after GC induction; Group Ⅳ was treadmill exercise and Eucommia ulmoides Oliver feeding after GC induction. In the bone mineral density and bone strength test, there was a statistically significant difference between the group Ⅰ, Ⅱ, Ⅲ compared to group Ⅳ(p<0.05). In the osteocalcin level as one of bone formation indexes, there was a statistically significant difference between the group Ⅰ, Ⅱ, Ⅲ compared to group Ⅳ(p<0.05). In respect to the calcium there was a statistically significant difference between group Ⅰ, Ⅱ, Ⅲ compared to group Ⅳ(p<0.05). In respect to histological findings, the group Ⅳ showed mild femur disruption and lytic change on femur section. The above results suggests that Eucommia ulmoides Oliver medicated and treadmill exercise is effective to prevention and treatment of osteoporosis.

참고문헌 (46)

  1. Kaufman, J.D, "Osteoporosis and prevention of fractures : Practical Approaches for Orthopaedic Surgeon", Instructional Course Lectures, 51, pp.559~565 (2002)
  2. Kannus, P, "Prevention of hip fracture in elderly people with use of a hip protector", New England Journal of Medicine, 343, pp.1506~1513 (2000)
  3. Aloia, J.F, "Risk factors for postmenopausal osteoporosis", Am J Med, 78, pp.95~100 (1985)
  4. Riggs, B.L, "Medical progress: Involutional Osteoporosis", N Eng J Med, 314, pp.1676~1686 (1986)
  5. Adachi, J.D, "Intermittent etidronate therapy to prevent corticosteroid-induced osteoporosis", N Engl J Med, 337, pp.382~387 (1997)
  6. Canalis, E, "Clinical review 83. Mechanisms of glucocorticoid action in bone: implications to glucocorticoid-induced osteoporosis", J Clin Endocrinol Metab, 81, pp.3441~3447 (1996)
  7. Reid, I.R, "Pathogenesis and treatment of steroid osteoporosis", Clin Endocrinol, 30, pp.83~103 (1989)
  8. Adachi, J.D, "Corticosteroid-induced osteoporosis", Am J Med Sci, 313, pp.41~49 (1997)
  9. 박형무, "폐경기 골다공증의 치료", Osteoporosis update, 4(1), pp.12~20 (2003)
  10. Frolik, C.A, "Time-dependent changes in biochemical bone markers and serum cholesterol in ovariectomized rats: Effects of raloxifene HCl, tamoxifen, estrogen and alendronate", Bone, 18, pp.621~627 (1996)
  11. Cranney, A, "Meta-analyses of therapies for postmenopausal osteoprosis. Ⅱ. Meta-analysis of alendronate for the treatment of postmenopausal women", Endocrine Rev, 23, pp.508~516 (2002)
  12. Bone, H.G, "Ten year's experience with alendronate for osteoporosis in postmenopausal women", N Engl J Med, 350, pp.1189~1199 (2004)
  13. Li, Y, "Improvement in the turnover rate of the stratum corneum in false aged model rats by the administration of geniposide acid in Eucommia ulmoides oliver leaf", Biol Pharm Bull, 22(6), pp.582~585 (1999)
  14. Li, Y, "Changes in lactate dehydrogenase and 3-hydroxyacetyl-CoA dehydrogenase activities in rat muscle by the administration of Eucommia ulmoides oliver leaf with spontaneous of running training", Biol Pharm Bull, 22(9), pp.941~946 (1999)
  15. Watanabe, Jun, "Ryoya Niki Isolation and identification of a-glucosidase inhibitors from tochu-cha(Eucommia ulmoides)", Biosci Biotech Biochem, 61(1), pp.177~178 (1997)
  16. Kim, K.C, "Drugs for the treatment of hypertension Ⅱ. Toxicity and experimental therapy of Eucommia ulmoides", Acta. Physiol. Sin, 20, pp.247~254 (1959)
  17. Chien, T.H, "Pharmacological cation of Eucommia ulmoides", Jpn J Pharmacol, 6, pp.122~137 (1957)
  18. Xu, S.L, "Effects of Duzhong on plasma cAMP and cGMP levels on mice", Chin Trad Herbal Drugs, 17, pp.204~ (1986)
  19. Oh, H.S, "Effects of Eucommia cortex and folium on the ovariectomized rat as the model of postmenopausal osteoporosis", J Herbology, 10(1), pp.59~68 (1995)
  20. Cornelia, M.U, "Bone mineral density in mother-daughter pairs: relations to lifetime exercise, lifetime milk consumption and calcium supplements", Am J Clinical Nutrition, 63, pp.72~79 (1996)
  21. Karlsson, M.K, "Bone mineral density in weight lifter", Calcif Tissue Int, 52(3), pp.212~215 (1993)
  22. Nishimura, J, "Glucocorticoid-induced osteo- porosis: pathogenesis and management", J Bone Miner Metab, 18, pp.3350~3352 (2000)
  23. 조대승, "Alendronate 투여와 트레드밀 운동이 골량감소 모데 흰쥐의 골밀도에 미치는 영향", 운동영양학회지, 6(2), pp.109~113 (2002), 한국운동영양학회
  24. Wasnich, R.D, "Bone mass measurements in diagnosis and assessment of therapy", Am J Med, 91, pp.54~ (1991)
  25. Giesen, E.B.W, "Reduced mechanical load decreases the density, stiffness, and strength of cancellous bone of the mandibular condyle", Clinical Biomechanics, 18(4), pp.358~363 (2003)
  26. 오한진, "QCT를 이용하여 측정한 한국인 중년남자의 골밀도", 대한골대사학회지, 5(2), pp.150~155 (1998)
  27. Kanis, J.A, "Diagnosis of osteoporosis and assessment of fracture risk", Lancet, 359(9321), pp.1929~1936 (2002)
  28. Murray, D.W, "Bone growth and remodelling after fracture", J Bone Joint Surg Br, 78, pp.42~50 (1996)
  29. Kasperk, C, "Differential effects of glucocorticoids on human osteoblastic cell metabolism in vitro", Calcif Tissue Int, 57, pp.120~126 (1995)
  30. Gonnelli, S, "Prevention of corticosteroid-induced osteoporosis with alendronate in sarcoid patients", Calcif Tissue Int, 61, pp.382~385 (1997)
  31. Bellows, C.G, "Physiological concentrations of glucocorticoid stimulate formation of bone nodules from isolated rat calvaria cells in vitro", Endocrinology, 21, pp.1985~1992 (1987)
  32. Knauper, V, "Biochemical characterization of human collagenase-3", J Biol Chem, 19(271), pp.1544~1550 (1996)
  33. Rifas, L, "Expression of metalloproteinase and tissue inhibitors of metalloproteinases in human osteoblast -like cells: differentiation is associated with expression of metalloproteinase biosynthesis", Endocinology, 134, pp.213~221 (1994)
  34. Diez, F, "Guidelines for the diagnosis of osteoporosis by densitometric methods", J Manipulative Physiol Ther, 25, pp.403~415 (2002)
  35. Lee, D.S, "Effects of the dietary mixture of Eucommiae ulmoides oliver on osteoporosis", Kor J Biotechnol Bioeng, 16, pp.614~619 (2001)
  36. 이종안, "杜冲과 木瓜의 혼합전탕액이 흰쥐의 난소적출로 유발한 골다공증에 미치는 영향", 본초학회지, 16, pp.201~206 (2001)
  37. Pruitt, L.A, "Effects of a one-year high-intensity versus low-intensity resistance training program on bone mineral density in older women", J Bone Miner Res, 10, pp.1788~1795 (1995)
  38. Bilston, L.E, "Zoledronic acid improves the mechanical properties of normal and healing bone", Clin Biomech(Bristol Avon), 17, pp.716~718 (2002)
  39. 황명훈, "체중부하운동이 흰쥐의 골대사에 미치는 영향", 제 38회 한국체육학회 학술발표회, pp.391~397 (2001)
  40. 한병권, "한국인 갱년기 여성의 골밀도 및 호르몬 변화에 대한 연구", 대한내분비학회지, 4, pp.21~28 (1989)
  41. Bowles, S.A, "Serum osteocalcin, total and bone-specific alkaline phosphate following isolated tibial shaft fracture", Ann Clin Biochem, 33, pp.196~200 (1996)
  42. Morris, Notelovitz, "Osteoporosis, screening, prevention, and management", Fertility and Sterility, 59(4), pp.707~725 (1993)
  43. 오한진, "폐경 후 골다공증의 치료방법별 효과 및 골대사 지표 변화에 의한 골밀도 변화의 예측성", 가정의학회지, 22(8), pp.1234~1246 (2001)
  44. 서부일, "녹각이 흰쥐의 난소적출로 유발한 골다공증에 미치는 영향", 대한본초학회지, 13(2), pp.45~56 (1998)
  45. Nordin, B.E, "Calcium and osteoporosis", Nutrition, 13, pp.664~686 (1997)
  46. Yamazaki, I, "Charicteristics of an ovariectomized osteopenic rat model", J Bone Min Res, 4(1), pp.13~23 (1989)

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