역류성 식도염에 대한 二陳湯加味方 효과 연구
Effects of Yijin-tang-gamibang Extracts on Reflux Esophagitis
2
조회
0
다운로드
14
인용
0
참고문헌
키워드
초록
The object of this study was to observe the protective effects of Yijin-tang-gamibang (YJGMB), Yijin-tang has been traditionally used as Korean medicine for treating various digestive diseases. The study showed that it is effective on reflux esophagitis induced by pylorus and forestomach ligation in rats. Three different dosages of Yijin-tang-gamibang extracts, 300, 150 and 75 ㎎/㎏, were once orally administered 1 hour before pylorus ligation. 6 groups, each of 8 rats per group were used in the present study. The results were compared with Omeprazole, antioxidant and proton pump inhibitor, 30 ㎎/㎏ treated group. Yijin-tang-gamibang extracts 300 ㎎/㎏ were showed similar or slightly lower effects as compared with 30 ㎎/㎏ of omeprazole in the present study. Detail mechanism studies should be conduced in future with the efficacy tests of individual herbal composition of Yijin-tang-gamibang and the screening of the biological active compounds in herbs.
Abstract
The object of this study was to observe the protective effects of Yijin-tang-gamibang (YJGMB), Yijin-tang has been traditionally used as Korean medicine for treating various digestive diseases. The study showed that it is effective on reflux esophagitis induced by pylorus and forestomach ligation in rats. Three different dosages of Yijin-tang-gamibang extracts, 300, 150 and 75 ㎎/㎏, were once orally administered 1 hour before pylorus ligation. 6 groups, each of 8 rats per group were used in the present study. The results were compared with Omeprazole, antioxidant and proton pump inhibitor, 30 ㎎/㎏ treated group. Yijin-tang-gamibang extracts 300 ㎎/㎏ were showed similar or slightly lower effects as compared with 30 ㎎/㎏ of omeprazole in the present study. Detail mechanism studies should be conduced in future with the efficacy tests of individual herbal composition of Yijin-tang-gamibang and the screening of the biological active compounds in herbs.
참고문헌 (30)
- 박인서, "유리산소기와 소화기계 질환", 진단과 치료, 13(5), pp.548~554 (1993)
- Spechler, S,J., "Comparison of medical and surgical therapy for complicated gastroesophageal reflux disease in Veteran", N Eng J Med, 326(12), pp.786~792 (1992)
- DeVault, K.R., "Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease", Am J Gastroenterol, 94(6), pp.1434~1442 (1999)
- Barron, J.J., "Proton pump inhibitor utilization patterns in infants", J Pediatr Gastroenterol Nutr., 45(4), pp.421~427 (2007)
- Tonini, M., "Potential options to optimize therapy of gastroesophageal reflux disease with proton pump inhibitors", Digestion, 76(3), pp.171~178 (2007)
- McKeage, K., "Esomeprazole: a review of its use in the management of gastric acid-related diseases in adults", Drugs, 68(11), pp.1571~1607 (2008)
- 鞠潤範, "方劑學", pp.528~, 圖書出版 永林社
- 장태수, "이진탕의 진통 진경(鎭痙) 소염 및 GASTRIN 과 UROPEPSIN 의 분비에 미치는 영향", 東西醫學, 7(1), pp.46~48 (1982)
- 김행애, "二陳湯이 白鼠 胃運動 및 胃液分泌에 미치는 影響", 석사, pp.1990
- 최정우, "二陳湯 전탕액이 흰쥐 위의 Gastrin, Histamine, Somatostatin면역반응세포에 미치는 영향", 동의생리병리학회지, 15(4), pp.554~559 (2001), 대한동의병리학회
- 허준, "동의보감", pp.1126~1166 (2002), 법인문화사
- 김봉석, "二陳湯加味方과 침치료를 병행한 비미란성 위식도역류질환 환자 7인 증례보고", 대한한방내과학회지, 26(4), pp.926~934 (2005), 대한한방내과학회
- 오중한, "二陳湯 加味方 투여 후 호전된 기능성 소화불량 환자 3례에 대한 증례보고", 대한한방내과학회지, 26(3), pp.641~651 (2005), 대한한방내과학회
- "Department of Health, Education, and Welfare Publication (National Institute of Health)", 85~23 (1985)
- Rao, C.V., "Effect of quercetin, flavonoids and alpha-tocopherol, an antioxidant vitamin on experimental reflux oesophagitis in rats", Eur J Pharmacol, 589(1), pp.233~238 (2008)
- Nakamura, K., "Effects of sodium polyacrylate (PANa) on acute esophagitis by gastric juice in rats", Jpn J Pharmacol., 32, pp.445~456 (1982)
- Sharma, J.N., "Role of nitric oxide in inflammatory diseases", Inflammopharmacology, 15(6), pp.252~259 (2007)
- Bicakci, U., "Effects of omeprazole and gentamicin on the biochemical and histopathological alterations of the hypoxia", reoxygenation induced intestinal injury in newborn rats, 2005, pp.21(10), 800~805
- Katada, K., "Prevention by rebamipide of acute reflux esophagitis in rats", Dig Dis Sci., 50(1), pp.S97~S103 (2005)
- Min, Y.S., "The effect of luteolin-7-O-beta-D-glucuronopyranoside on gastritis and esophagitis in rats", Arch Pharm Res., 29(6), pp.484~489 (2006)
- DeMeester, T.R., "Clinical and in vitro analysis of determinants of gastroesophageal competence: a study of the principles of antireflux surgery", Am J Surg., 137(1), pp.39~46 (1979)
- Hunt, R.H., "Importance of pH control in the management of GERD", Arch Intern Med., 159(7), pp.649~657 (1999)
- Meuwissen, S.G.M., "Treatment of reflux oesophagitis with H2-receptor antagonist", Scand J Gastroenterol, 23(146), pp.201~213 (1988)
- Gartner, L.P., "Color Textbook of Histology, third edition", pp.381~411 (2007), Elsevier
- Katz, P.O., "Lessons learned from intragastric pH monitoring", J Clin Gastroenterol., 33(2), pp.107~113 (2001)
- Farhadi, A., "Reactive oxygen species: are they involved in the pathogenesis of GERD, Barrett's esophagus and the Latter's progression toward Esophageal cancer?", Am J Gastroenterol, 97(1), pp.22~26 (2002)
- Claiborne, A., "Catalase activity. in: CRS Handbook of Methods for Oxygen Radical Research", pp.283~284 (1985), CRC Press
- Das, D., "Effect of stress on the antioxidant enzymes and gastric ulceration", Mol Cell Biochem, 125(2), pp.115~125 (1993)
- Wiseman, H., "Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progressive to cancer", Biochem J., 313(1), pp.17~29 (1996)
- 김동현, "한방약리학", pp.49~53 (2006), 신일상사