웨이브프론트의 연속 측정방법으로 분석한 눈물막의 불안정성에 따른 고위수차 변화
Changes in Higher Order Aberration According to Tear-Film Instability Analyzed by Continuous Measurement Using Wavefront
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목적: 눈물막의 불안정성에 따른 고위수차 변화를 KR-1WⓇ 웨이브프론트 분석기로 10초간 연속으로 측정하고, 눈물막파괴시간, 쉬르머검사 및 점상각막염과의 관계를 분석하고자 하였다. 대상과 방법: 환자 114명 228안을 대상으로 KR-1WⓇ 웨이브프론트 분석기의 연속 측정방법을 이용하여 눈 깜박임 후 10초 동안 매초고위수차를 측정하였다. 결과: 시간이 경과할수록 고위수차가 증가하는 양상이었고, 마지막 측정값인 눈 깜박임 후 10초에서 첫 측정값인 눈 깜박임 후 1초의값을 뺀 수차의 변화량은 통계적으로 의미가 있었다(p=0.004). 매초 사이의 변화량을 측정하였고, 눈 깜박임 후 9초와 10초 사이 변화량이 통계적으로 의미 있게 증가하였다(p=0.01). 수차의 변화량은 눈물막 파괴시간이 6초 미만인 군에서 변화량이 가장 컸고 통계적으로 의미가 있었다(p=0.002). 쉬르머검사에서 10 mm 초과인 군과 점상각막염이 있는 군이 수차의 변화량이 컸고 통계적으로 의미가있었다(p=0.008, p=0.005). 결론: 안구건조증 환자에서 시력의 질 저하의 원인 규명과 진단 및 다양한 치료방법의 평가에 웨이브프론트의 고위수차 분석이 유용하게 사용될 것으로 생각한다.
Abstract
Purpose: To evaluate the changes of higher order aberration according to tear-film instability measured serially by KR-1W wavefront every second for 10 seconds. The present study also analyzed the relationship between higher order aberration and the tear-film break-up time, Schirmer test, and superficial punctate keratitis. Methods: The 228 eyes of 114 patients randomly selected from patients who visited hospital were measured once every second for 10 seconds after eye blinking by continuous measurement using wavefront. Results: Higher order aberration increased overtime, and the higher order aberration value measured at the tenth second subtracted from the value of the first second was statistically significant (p = 0.004). In addition, the increment in higher order aberration between 9 seconds and 10 seconds was statistically significant (p = 0.01). The group of patients with a tear-film break-up time less than 6 seconds showed the greatest changes when measuring the higher order aberration difference value between the tenth and first seconds, which was statistically significant (p = 0.002). The group of patients where the Schirmer test results were longer than 10 millimeters and who had superficial punctate keratitis showed the greatest statistically significant changes when measuring the difference in higher order aberration values between the tenth and first seconds (p = 0.008, p = 0.005, respectively). Conclusions: Analysis of higher order aberration by wavefront could be useful in cases of decreased optical quality, diagnosis and evaluation of treatment in dry eye syndrome.
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