정상안압녹내장에서 브린졸라미드 1%와 티몰롤 0.5% 혼합제제의 효과
The Effect of Fixed Combination of Brinzolamide 1% and Timolol 0.5% in Normal-Tension Glaucoma
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목적: 정상안압녹내장에서 Brinzolamide 1%와 Timolol 0.5% 혼합제제의 안압 하강 효과에 대해 알아보고자 한다. 대상과 방법: 단안에만 brinzolamide/timolol 혼합제제를 사용하고 있는 정상안압녹내장 환자 33명을 대상으로 하였다. 녹내장 외래에서 오전 9시부터 오후 4시 30분까지 2시간 30분 간격으로 안압을 측정하였으며, 혼합제제를 하루 2회(오전 8시, 오후 8시), 6개월간단안 점안 후 동일한 시간대에 안압을 다시 측정하였다. 점안안과 비점안안에서 안압 하강 효과에 대해 비교 분석하였다. 결과: 혼합제제 점안 후 점안안에서 평균 -2.85 ± 1.43 mmHg (-18.36 ± 8.58%), 비점안안에서 평균 -2.21 ± 1.73 mmHg(-13.90± 10.66%)로 양안 모두 유의한 안압 하강 효과를 보였으며, 점안안에서 안압 하강 효과가 더 크게 나타났다. 혼합제제 점안 후 점안안과 비점안안에서 시간대별 안압은 오전 11시 30분에 가장 낮고 이후 증가하는 양상으로 변화를 보였다. 또한 점안 후 초기 안압과비교하여 1개월째 안압 하강 효과가 가장 크게 나타났으며, 3개월과 6개월째에도 유의한 안압 하강 효과가 지속되었다. 안과적 손상을유발할 만한 심각한 부작용은 나타나지 않았다. 결론: 정상안압녹내장에서 brinzolamide/timolol 혼합제제는 점안안과 비점안안에서 효과적으로 안압을 하강시켰다.
Abstract
Purpose: We conducted a study to evaluate the effects of brinzolamide/timolol fixed combination (BTFC) in normal-tension glaucoma(NTG) patients. Methods: We reviewed the records of 33 normal-tension glaucoma patients treated with BTFC in the unilateral eye. We measuredintraocular pressure (IOP) every 2 and 1/2 hours between 09:00 am and 04:30 pm. After using BTFC at 8:00 am and 8:00pm for 6 months, we measured the IOP at the same time period. We analyzed and compared the IOP of eyes treated with BTFCand contralateral eyes. Results: The mean reduction in IOP was -2.85 ± 1.43 mm Hg (-18.36 ± 8.58%) in the eyes treated with BTFC and -2.21 ± 1.73mm Hg (-13.90 ± 10.66%) in the contralateral eyes. The IOP lowering effect was greater in the eyes treated with BTFC than in thecontralateral eyes. After 6 months of BTFC instillation, the changes in IOP measurements were the lowest at 11:30 am and increasedat each time point afterwards. The greatest reduction in IOP was observed at 1 month; however, significant IOP reductionwas observed at 3 and 6 months in both BTFC and contralateral eyes. There was no serious adverse event causing oculardamage. Conclusions: BTFC provided a significant IOP reduction in both BTFC and contralateral eyes in NTG patients.
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