Understanding intestinal health in nursery pigs and the relevant nutritional strategies
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In the modern pig production, pigs are weaned at early age with immature intestine. Dietary and environmental factors challenge the intestine, specifically the jejunum, causing inflammation and oxidative stress followed by destruction of epithelial barrier and villus structures in the jejunum. Crypt cell proliferation increases to repair damages in the jejunum. Challenges to maintain the intestinal health have been shown to be related to changes in the profile of mucosa-associated microbiota in the jejunum of nursery pigs. All these processes can be quantified as biomarkers to determine status of intestinal health related to growth potential of nursery pigs. Nursery pigs with impaired intestinal health show reduced ability of nutrient digestion and thus reduced growth. A tremendous amount of research effort has been made to determine nutritional strategies to maintain or improve intestinal health and microbiota in nursery pigs. A large number of feed additives have been evaluated for their effectiveness on improving intestinal health and balancing intestinal microbiota in nursery pigs. Selected prebiotics, probiotics, postbiotics, and other bioactive compounds can be used in feeds to handle issues with intestinal health. Selection of these feed additives should aim modulating biomarkers indicating intestinal health. This review aims to define intestinal health and introduce examples of nutritional approaches to handle intestinal health in nursery pigs.
Abstract
In the modern pig production, pigs are weaned at early age with immature intestine. Dietary and environmental factors challenge the intestine, specifically the jejunum, causing inflammation and oxidative stress followed by destruction of epithelial barrier and villus structures in the jejunum. Crypt cell proliferation increases to repair damages in the jejunum. Challenges to maintain the intestinal health have been shown to be related to changes in the profile of mucosa-associated microbiota in the jejunum of nursery pigs. All these processes can be quantified as biomarkers to determine status of intestinal health related to growth potential of nursery pigs. Nursery pigs with impaired intestinal health show reduced ability of nutrient digestion and thus reduced growth. A tremendous amount of research effort has been made to determine nutritional strategies to maintain or improve intestinal health and microbiota in nursery pigs. A large number of feed additives have been evaluated for their effectiveness on improving intestinal health and balancing intestinal microbiota in nursery pigs. Selected prebiotics, probiotics, postbiotics, and other bioactive compounds can be used in feeds to handle issues with intestinal health. Selection of these feed additives should aim modulating biomarkers indicating intestinal health. This review aims to define intestinal health and introduce examples of nutritional approaches to handle intestinal health in nursery pigs.
참고문헌 (83)
- Farr MM, "Sulfamerazine therapy in experimental cecal coccidiosis of chickens", J Parasitol, 31, pp.353~358 (1945)[DOI]
- Moore PR, "Use of sulfasuxidine, streptothricin, and streptomycin in nutritional studies with the chick", J Biol Chem, 165, pp.437~441 (1946)[DOI]
- Whitehill AR, "Stimulatory effect of aureomycin on the growth of chicks", Exp Biol Med, 74, pp.11~13 (1950)[DOI]
- Carpenter LE, "The effect of antibiotics and vitamin B12 on the growth of swine", Arch Biochem Biophys, 32, pp.187~191 (1951)[DOI]
- Cunha TJ, "A comparison of aureomycin, streptomycin, penicillin and an aureomycin-B12 feed supplement for the pig", Arch Biochem, 30, pp.269~271 (1951)
- Luecke RW, "The growth promoting effects of various antibiotics on pigs", J Anim Sci, 10, pp.538~542 (1951)[DOI]
- Becker DE, "Supplementary protein and the response of the pig to antibiotics", J Anim Sci, 14, pp.492~498 (1955)[DOI]
- Cromwell GL, "Why and how antibiotics are used in swine production", Anim Biotechnol, 13, pp.7~27 (2002)[DOI]
- Kim SW, "Nonruminant nutrition symposium on natural phytobiotics for health of young animals and poultry : mechanisms and application", J Anim Sci, 86(Suppl 14), pp.E138~E139 (2008)[DOI]
- Casewell M, "The European ban on growth-promoting antibiotics and emerging consequences for human and animal health", J Antimicrob Chemother, 52, pp.159~161 (2003)[DOI]
- The U. S. and EU animal pharmaceutical industries in the age of antibiotic resistance, "Sneeringer S", USDA, ~, pp.Report No. :ERR264 (2019)
- Schoenmakers K, "How China is getting its farmers to kick their antibiotics habit", Nature, 586, pp.S60~S62 (2020)[DOI]
- Pluske JR, "Feed-and feed additives-related aspects of gut health and development in weanling pigs", J Anim Sci Biotechnol, 4, pp.1~ (2013)[DOI]
- Eisemann J, "Animal nutrition" (2014), Kendall Hunt Publishing
- Pond WG, "Biology of the domestic pig", pp.2001, Comstock Pub. Associates
- Smith F, "Early weaning stress impairs development of mucosal barrier function in the porcine intestine", Am J Physiol Gastrointest Liver Physiol, 298, pp.G352~G363 (2010)[DOI]
- Moeser AJ, "Gastrointestinal dysfunction induced by early weaning is attenuated by delayed weaning and mast cell blockade in pigs", Am J Physiol Gastrointest Liver Physiol, 293, pp.G413~G421 (2007)[DOI]
- Taliercio E, "Epitopes from two soybean glycinin subunits are antigenic in pigs", J Sci Food Agric, 93, pp.2927~2932 (2013)[DOI]
- Alexandra C. Chaytor, "Occurrence and Decontamination of Mycotoxins in Swine Feed", Animal Bioscience, 24(5), pp.723~738 (2011), 아세아·태평양축산학회
- Liener IE, "Soy in animal nutrition", pp.13~45 (2000), Federation of Animal Science Societies
- Taliercio E, "Identification of a second major antigenic epitope in the α-subunit of soy β-conglycinin", Food Agric Immunol, 25, pp.311~321 (2014)[DOI]
- Smith BN, "Immunomodulatory potential of dietary soybean-derived isoflavones and saponins in pigs", J Anim Sci, 96, pp.1288~1304 (2018)[DOI]
- Chen H, "Effects of supplemental xylanase on health of the small intestine in nursery pigs fed diets with corn distillers’ dried grains with solubles", J Anim Sci, 98 (2020)[DOI]
- Duarte ME, "Synbiotic effects of enzyme and probiotics on intestinal health and growth of newly weaned pigs challenged with enterotoxigenic F18+ Escherichia coli", Front Vet Sci, 7, pp.573~ (2020)[DOI]
- Holanda DM, "Efficacy of mycotoxin detoxifiers on health and growth of newly-weaned pigs under chronic dietary challenge of deoxynivalenol", Toxins, 12, pp.311~ (2020)[DOI]
- Kim SW, "Efficacy of a yeast cell wall extract to mitigate the effect of naturally co-occurring mycotoxins contaminating feed ingredients fed to young pigs : impact on gut health, microbiome, and growth", Toxins, 11, pp.633~ (2019)[DOI]
- Pearce SC, "Heat stress and reduced plane of nutrition decreases intestinal integrity and function in pigs", J Anim Sci, 91, pp.5183~5193 (2013)[DOI]
- Dinarello CA, "Proinflammatory cytokines", Chest, 118, pp.503~508 (2000)[DOI]
- Opal SM, "Anti-inflammatory cytokines", Chest, 117, pp.1162~1172 (2000)[DOI]
- Friedrich M, "Cytokine networks in the pathophysiology of inflammatory bowel disease", Immunity, 50, pp.992~1006 (2019)[DOI]
- Xue X, "The role of immune cells and cytokines in intestinal wound healing", Int J Mol Sci, 20, pp.6097~ (2019)[DOI]
- Bhattacharyya A, "Oxidative stress : an essential factor in the pathogenesis of gastrointestinal mucosal diseases", Physiol Rev, 94, pp.329~354 (2014)[DOI]
- Berchieri-Ronchi CB, "Oxidative stress status of highly prolific sows during gestation and lactation", Animal, 5, pp.1774~1779 (2011)[DOI]
- Zhao Y, "Effect of social ranks and gestation housing systems on oxidative stress status, reproductive performance, and immune status of sows", J Anim Sci, 91, pp.5848~5858 (2013)[DOI]
- Yan Zhao, "Oxidative stress status and reproductive performance of sows during gestation and lactation under different thermal environments", Animal Bioscience, 33(5), pp.722~731 (2020), 아세아·태평양축산학회[DOI]
- In Kyu Lee, "Stress, Nutrition, and Intestinal Immune Responses in Pigs — A Review", Animal Bioscience, 29(8), pp.1075~1082 (2016), 아세아·태평양축산학회[DOI]
- Jang KB, "Supplemental effects of dietary nucleotides on intestinal health and growth performance of newly weaned pigs", J Anim Sci, 97, pp.4875~4882 (2019)[DOI]
- Patankar JV, "Cell death in the gut epithelium and implications for chronic inflammation", Nat Rev Gastroenterol Hepatol, 17, pp.543~556 (2020)[DOI]
- Kuhn KA, "IL-6 stimulates intestinal epithelial proliferation and repair after injury", PLoS One, 9, pp.e114195~ (2014)[DOI]
- MacDonald TT, "Epithelial proliferation in response to gastrointestinal inflammation", Ann NY Acad Sci, 664, pp.202~209 (1992)[DOI]
- Tiwari UP, "Supplemental effect of xylanase and mannanase on nutrient digestibility and gut health of nursery pigs studied using both in vivo and in vitro models", Anim Feed Sci Technol, 245, pp.77~90 (2018)[DOI]
- Charepalli V, "Pigs, unlike mice, have two distinct colonic stem cell populations similar to humans that respond to high-calorie diet prior to insulin resistance", Cancer Prev Res, 10, pp.442~450 (2017)[DOI]
- Chen H, "Impacts of energy feeds and supplemental protease on growth performance, nutrient digestibility, and gut health of pigs from 18 to 45 kg body weight", Anim Nutr, 3, pp.359~365 (2017)[DOI]
- Guan G, "Biological effects and applications of chitosan and chito-oligosaccharides", Front Physiol, 10, pp.516~ (2019)[DOI]
- Burrough ER, "Comparison of the luminal and mucosa-associated microbiota in the colon of pigs with and without swine dysentery", Front Vet Sci, 4, pp.139~ (2017)[DOI]
- Adhikari B, "Characterization of microbiota associated with digesta and mucosa in different regions of gastrointestinal tract of nursery pigs", Int J Mol Sci, 20, pp.1630~ (2019)[DOI]
- Belkaid Y, "Role of the microbiota in immunity and inflammation", Cell, 157, pp.121~141 (2014)[DOI]
- Mulder IE, "Restricting microbial exposure in early life negates the immune benefits associated with gut colonization in environments of high microbial diversity", PLoS One, 6, pp.e28279~ (2011)[DOI]
- Arpaia N, "Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation", Nature, 504, pp.451~455 (2013)[DOI]
- Buffie CG, "Microbiota-mediated colonization resistance against intestinal pathogens", Nat Rev Immunol, 13, pp.790~801 (2013)[DOI]
- Jang KB, "Supplemental effects of dietary lysophospholipids in lactation diets on sow performance, milk composition, gut health, and gut-associated microbiome of offspring", J Anim Sci, 98 (2020)[DOI]
- Li P, "Microbial shifts in the porcine distal gut in response to diets supplemented with Enterococcus faecalis as alternatives to antibiotics", Sci Rep, 7, pp.41395~ (2017)[DOI]
- Thacker PA, "Alternatives to antibiotics as growth promoters for use in swine production : a review", J Anim Sci Biotechnol, 4, pp.35~ (2013)[DOI]
- Yin J, "Nutrients and inflammatory diseases", Mediators Inflamm, 2017, pp.6134909~ (2017)[DOI]
- Flickinger EA, "Nutritional responses to the presence of inulin and oligofructose in the diets of domesticated animals : a review", Crit Rev Food Sci Nutr, 43, pp.19~60 (2003)[DOI]
- Jang KB, "Dose-response and functional role of whey permeate as a source of lactose and milk oligosaccharides on intestinal health and growth of nursery pigs", J Anim Sci, 99, pp.skab008~ (2021)[DOI]
- Barba-Vidal E, "Review : are we using probiotics correctly in post-weaning piglets", Animal, 12, pp.2489~2498 (2018)[DOI]
- Mathew AG, "Effects of a direct-fed yeast culture on enteric microbial populations, fermentation acids, and performance of weanling pigs", J Anim Sci, 76, pp.2138~2145 (1998)[DOI]
- Shen YB, "Effects of yeast culture supplementation on growth performance, intestinal health, and immune response of nursery pigs", J Anim Sci, 87, pp.2614~2624 (2009)[DOI]
- Holanda DM, "Investigation of the efficacy of a postbiotic yeast cell wall-based blend on newlyweaned pigs under a dietary challenge of multiple mycotoxins with emphasis on deoxynivalenol", Toxins, 12, pp.504~ (2020)[DOI]
- S.K. Kommera, "Phytobiotics and Organic Acids As Potential Alternatives to the Use of Antibiotics in Nursery Pig Diets", Animal Bioscience, 19(12), pp.1784~1789 (2006), 아세아·태평양축산학회
- Xiangfeng Kong, "Dietary Supplementation with Acanthopanax senticosus Extract Modulates Cellular and Humoral Immunity in Weaned Piglets", Animal Bioscience, 20(9), pp.1453~1461 (2007), 아세아·태평양축산학회
- Lu T, "Protective effects of Forsythia suspensa extract against oxidative stress induced by diquat in rats", Food Chem Toxicol, 48, pp.764~770 (2010)[DOI]
- Kim SW, "Use of carbohydrases in corn–soybean meal-based nursery diets", J Anim Sci, 81, pp.2496~2504 (2003)[DOI]
- Passos AA, "Effect of dietary supplementation of xylanase on apparent ileal digestibility of nutrients, viscosity of digesta, and intestinal morphology of growing pigs fed corn and soybean meal based diet", Anim Nutr, 1, pp.19~23 (2015)[DOI]
- Duarte ME, "Dietary supplementation of xylanase and protease on growth performance, digesta viscosity, nutrient digestibility, immune and oxidative stress status, and gut health of newly weaned pigs", Anim Nutr, 5, pp.351~358 (2019)[DOI]
- Shen YB, "Effect of feed grade L-methionine on growth performance and gut health in nursery pigs compared with conventional DL-methionine", J Anim Sci, 92, pp.5530~5539 (2014)[DOI]
- Sung Woo Kim, "Functional Amino Acids and Fatty Acids for Enhancing Production Performance of Sows and Piglets", Animal Bioscience, 20(2), pp.295~306 (2007), 아세아·태평양축산학회
- Kim SW, "Regulatory role of amino acids in pigs fed on protein-restricted diets", Curr Protein Pept Sci, 20, pp.132~138 (2019)[DOI]
- Pearlin BV, "Role of acidifiers in livestock nutrition and health : a review", J Anim Physiol Anim Nutr, 104, pp.558~569 (2020)[DOI]
- Ferronato G, "Dietary supplementation of inorganic, organic, and fatty acids in pig : a review", Animals, 10, pp.1740~ (2020)[DOI]
- Weaver AC, "Supplemental nucleotides high in inosine 5′-monophosphate to improve the growth and health of nursery pigs", J Anim Sci, 92, pp.645~651 (2014)[DOI]
- Chengquan Tan, "Effects of dietary supplementation of nucleotides from late gestation to lactation on the performance and oxidative stress status of sows and their offspring", Animal Nutrition, 7(1), pp.111~118 (2021), Elsevier BV[DOI]
- Tran THT, "Review on the effects of potential prebiotics on controlling intestinal enteropathogens Salmonella and Escherichia coli in pig production", J Anim Physiol Anim Nutr, 102, pp.17~32 (2018)[DOI]
- Sun Y, "Dietary inclusion of multispecies probiotics in preventing post-weaning diarrhea caused by F18+ E. coli in pigs", Anim Nutr (2021)
- Sun Y, "Intestinal challenge with enterotoxigenic Escherichia coli in pigs, and nutritional intervention to prevent postweaning diarrhea", Anim Nutr, 3, pp.322~330 (2017)[DOI]
- Wu G, "Dietary glutamine supplementation prevents jejunal atrophy in weaned pigs", J Nutr, 126, pp.2578~2584 (1996)[DOI]
- Kim SW, "Dietary arginine supplementation enhances the growth of milk-fed young pigs", J Nutr, 134, pp.625~630 (2004)[DOI]
- Zhan Z, "Dietary arginine supplementation affects microvascular development in the small intestine of early-weaned pigs", J Nutr, 138, pp.1304~1309 (2008)[DOI]
- Brousseau JP, "Effects of probiotics Pediococcus acidilactici strain MA18", 5M and Saccharomyces cerevisiae subsp. boulardii strain SBCNCM I-1079 on fecal and intestinal microbiota of nursing and weanling piglets, 2015, pp.93, 5313~5326
- McConn BR, "Replacing dietary antibiotics with 0. 20%L-glutamine and synbiotics following weaning and transport in pigs", J Anim Sci, 98, pp.skaa272~ (2020)[DOI]
- Rodríguez-Sorrento A, "Effects of Bifidobacterium longum subsp. infantis CECT 7210 and Lactobacillus rhamnosus HN001, combined or not with oligofructose-enriched inulin, on weaned pigs orally challenged with Salmonella typhimurium", Front Microbiol, 11, pp.2012~ (2020)[DOI]
