자궁경부의 림프상피양 암종 1예
A case of lymphoepithelioma-like carcinoma of the uterine cervix
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림프상피암 또는 수질 암종이라고도 하는 자궁경부의 림프상피양 암종은 편평상피세포암의 변종 중 하나로 매우 드물게 발생한다. 조직학적으로 심한 만성 염증세포의 침전으로 둘러싸여 있으며 풍부한 세포질과 불분명한 세포 경계를 가진 미분화성 종양세포들이 집단을 이루고 있는 것이 특징이다. EBV가 자궁경부 림프상피양 암종의 발생에 관련되어 있을 것으로 알려져 있으나 그 역할은 정확하게 밝혀지지 않았다. 또한 이 종양과 HPV의 관계도 확립되지 않은 실정이다. 자궁경부의 림프상피양 암종 환자들은 편평상피암에 비해 예후가 양호한 것으로 알려져 있다. 본 저자들은 경부 림프상피양 암종 환자 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.
Abstract
Lymphoepithelioma-like carcinoma (LELC) of the uterine cervix, also called lymphoepithelioma or medullary carcinoma, is a very rare variant of squamous cell carcinoma. Histologically, the tumor is characterized by groups and nests of poorly differentiated tumor cells with abundant cytoplasm and ill-defined cell borders, surrounded by an intense chronic inflammatory infiltrate. Epstein-Barr virus (EBV) may be involved in the development of LELC but the exact role remains unclear. The relationship between human papillomavirus (HPV) and LELC of the uterine cervix has also not been reported. The prognosis of LELC of the uterine cervix seems to be better than that of cervical squamous cell carcinoma. We report a case of LELC of the uterine cervix with a brief review.
참고문헌 (14)
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