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Proposal for cervical cancer screening in the era of HPV vaccination

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초록

Eradication of cervical cancer involves the expansion of human papillomavirus (HPV) vaccine coverage and thedevelopment of efficient screening guidelines that take vaccination into account. In Korea, the HPV NationalImmunization Program was launched in 2016 and is expected to shift the prevalence of HPV genotypes in thecountry, among other effects. The experiences of another countries that implement national immunization programsshould be applied to Korea. If HPV vaccines spread nationwide with broader coverage, after a few decades, cervicalintraepithelial lesions or invasive cancer should become a rare disease, leading to a predictable decrease in thepositive predictive value of cervical screening cytology. HPV testing is the primary screening tool for cervical cancerand has replaced traditional cytology-based guidelines. The current screening strategy in Korea does not differentiatewomen who have received complete vaccination from those who are unvaccinated. However, in the post-vaccinationera, newly revised policies will be needed. We also discuss on how to increase the vaccination rate in adolescence.

Abstract

Eradication of cervical cancer involves the expansion of human papillomavirus (HPV) vaccine coverage and thedevelopment of efficient screening guidelines that take vaccination into account. In Korea, the HPV NationalImmunization Program was launched in 2016 and is expected to shift the prevalence of HPV genotypes in thecountry, among other effects. The experiences of another countries that implement national immunization programsshould be applied to Korea. If HPV vaccines spread nationwide with broader coverage, after a few decades, cervicalintraepithelial lesions or invasive cancer should become a rare disease, leading to a predictable decrease in thepositive predictive value of cervical screening cytology. HPV testing is the primary screening tool for cervical cancerand has replaced traditional cytology-based guidelines. The current screening strategy in Korea does not differentiatewomen who have received complete vaccination from those who are unvaccinated. However, in the post-vaccinationera, newly revised policies will be needed. We also discuss on how to increase the vaccination rate in adolescence.

참고문헌 (78)

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