A systematic review of clinical and laboratory parameters of 3,000 COVID-19 cases
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The coronavirus disease 2019 (COVID-19) has spread worldwide. It is still a pandemic and poses major health problemacross the globe. In our review, clinical characteristics and laboratory parameters of COVID-19 patients were compiledsystematically, with special reference to pregnant women in order to understand the disease course. An extensiveliterature search on various scientific databases for relevant manuscripts was conducted, which yielded 7 manuscriptsfor final analysis. The most common symptoms were fever (85%), cough (70.63%), chest tightness (37.36%),expectoration (33.27%), fatigue (32%), dyspnea (31.95%), and shortness of breath (31.19%), while hemoptysis (1.0%)was the least common. The associated comorbidities were hypertension (21.6%) and diabetes (10.0%). In terms ofhematological parameters, lower total leukocyte counts were observed in 65% of cases and biochemical parameters,patients demonstrated elevated levels of albumin (53.72%), lactate dehydrogenase (45.71%), and natriuretic peptide(34.84%); however, total bilirubin was elevated in only 8% of cases. In the acute inflammatory cytokine profile,C-reactive protein (59.0%), tumor necrosis factor (58.0%), erythrocyte sedimentation rate (57.0%), interleukin-2 (IL-2, 54.0%), and IL-6 (52.0%) levels were increased, while prolactin levels (6.5%) were minimally elevated. The recoveryrate was approximately 41%, and mortality was about 6.5%. The study also concluded that the clinical symptoms ofCOVID-19 were similar among pregnant and non-pregnant women. There was no evidence of vertical transmission ofCOVID-19 infection. This review critically analyzed COVID-19 as a public health hazard in order to help policy makers,health care givers, and primary physicians to promote early diagnosis and prevention.
Abstract
The coronavirus disease 2019 (COVID-19) has spread worldwide. It is still a pandemic and poses major health problemacross the globe. In our review, clinical characteristics and laboratory parameters of COVID-19 patients were compiledsystematically, with special reference to pregnant women in order to understand the disease course. An extensiveliterature search on various scientific databases for relevant manuscripts was conducted, which yielded 7 manuscriptsfor final analysis. The most common symptoms were fever (85%), cough (70.63%), chest tightness (37.36%),expectoration (33.27%), fatigue (32%), dyspnea (31.95%), and shortness of breath (31.19%), while hemoptysis (1.0%)was the least common. The associated comorbidities were hypertension (21.6%) and diabetes (10.0%). In terms ofhematological parameters, lower total leukocyte counts were observed in 65% of cases and biochemical parameters,patients demonstrated elevated levels of albumin (53.72%), lactate dehydrogenase (45.71%), and natriuretic peptide(34.84%); however, total bilirubin was elevated in only 8% of cases. In the acute inflammatory cytokine profile,C-reactive protein (59.0%), tumor necrosis factor (58.0%), erythrocyte sedimentation rate (57.0%), interleukin-2 (IL-2, 54.0%), and IL-6 (52.0%) levels were increased, while prolactin levels (6.5%) were minimally elevated. The recoveryrate was approximately 41%, and mortality was about 6.5%. The study also concluded that the clinical symptoms ofCOVID-19 were similar among pregnant and non-pregnant women. There was no evidence of vertical transmission ofCOVID-19 infection. This review critically analyzed COVID-19 as a public health hazard in order to help policy makers,health care givers, and primary physicians to promote early diagnosis and prevention.
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