Association between decreased ovarian reserve and poor oocyte quality
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ObjectiveTo analyze the association between oocyte quality and decreased ovarian reserve (DOR) markers in young womenundergoing controlled ovarian stimulation (COS). MethodsThis retrospective study included 49 patients classified as having DOR based on anti-Müllerian hormone (AMH)levels, follicle-stimulating hormone (FSH) levels, or antral follicle counts (AFCs; <10). Images of all obtained oocyteswere analyzed, and oocyte quality was classified according to maturity and morphology. The COS protocol utilizedgonadotropin (FSH and/or human menopausal gonadotropin [hMG]) doses ranging from 150 to 300 IU/day. TheStudent’s t test or Mann-Whitney test was used to compare the groups. Spearman’s coefficients were estimated toverify the correlation between the administered dose of FSH/hMG and the number of mature oocytes. To evaluate theassociation between patient- and oocyte-related variables, logistic regression models were adjusted. ResultsWomen with DOR classified according to FSH level had more immature oocytes (P<0.001). Women with DORaccording to AMH had fewer mature oocytes and increased basal FSH levels (P<0.001). Women with DOR according toAFC had an increased risk of abnormally shaped oocytes (P=0.035). ConclusionThis study showed that DOR based on AMH levels, FSH levels, and AFC was associated with poorer quality oocytes inyoung women who underwent COS.
Abstract
ObjectiveTo analyze the association between oocyte quality and decreased ovarian reserve (DOR) markers in young womenundergoing controlled ovarian stimulation (COS). MethodsThis retrospective study included 49 patients classified as having DOR based on anti-Müllerian hormone (AMH)levels, follicle-stimulating hormone (FSH) levels, or antral follicle counts (AFCs; <10). Images of all obtained oocyteswere analyzed, and oocyte quality was classified according to maturity and morphology. The COS protocol utilizedgonadotropin (FSH and/or human menopausal gonadotropin [hMG]) doses ranging from 150 to 300 IU/day. TheStudent’s t test or Mann-Whitney test was used to compare the groups. Spearman’s coefficients were estimated toverify the correlation between the administered dose of FSH/hMG and the number of mature oocytes. To evaluate theassociation between patient- and oocyte-related variables, logistic regression models were adjusted. ResultsWomen with DOR classified according to FSH level had more immature oocytes (P<0.001). Women with DORaccording to AMH had fewer mature oocytes and increased basal FSH levels (P<0.001). Women with DOR according toAFC had an increased risk of abnormally shaped oocytes (P=0.035). ConclusionThis study showed that DOR based on AMH levels, FSH levels, and AFC was associated with poorer quality oocytes inyoung women who underwent COS.
참고문헌 (21)
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