Linking resistin, inflammation, and cardiometabolic diseases
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Adipose tissue secretes a variety of bioactive substances that are associated with chronic inflammation, insulin resistance, and an increased risk of type 2 diabetes mellitus. While resistin was first known as an adipocyte-secreted hormone (adipokine) linked to obesity and insulin resistance in rodents, it is predominantly expressed and secreted by macrophages in humans. Epidemiological and genetic studies indicate that increased resistin levels are associated with the development of insulin resistance, diabetes, and cardiovascular disease. Resistin also appears to mediate the pathogenesis of atherosclerosis by promoting endothelial dysfunction, vascular smooth muscle cell proliferation, arterial inflammation, and the formation of foam cells. Thus, resistin is predictive of atherosclerosis and poor clinical outcomes in patients with cardiovascular disease and heart failure. Furthermore, recent evidence suggests that resistin is associated with atherogenic dyslipidemia and hypertension. The present review will focus on the role of human resistin in the pathogeneses of inflammation and obesity-related diseases.
Abstract
Adipose tissue secretes a variety of bioactive substances that are associated with chronic inflammation, insulin resistance, and an increased risk of type 2 diabetes mellitus. While resistin was first known as an adipocyte-secreted hormone (adipokine) linked to obesity and insulin resistance in rodents, it is predominantly expressed and secreted by macrophages in humans. Epidemiological and genetic studies indicate that increased resistin levels are associated with the development of insulin resistance, diabetes, and cardiovascular disease. Resistin also appears to mediate the pathogenesis of atherosclerosis by promoting endothelial dysfunction, vascular smooth muscle cell proliferation, arterial inflammation, and the formation of foam cells. Thus, resistin is predictive of atherosclerosis and poor clinical outcomes in patients with cardiovascular disease and heart failure. Furthermore, recent evidence suggests that resistin is associated with atherogenic dyslipidemia and hypertension. The present review will focus on the role of human resistin in the pathogeneses of inflammation and obesity-related diseases.
참고문헌 (66)
- Steppan CM, "The hormone resistin links obesity to diabetes", Nature, 409, pp.307~312 (2001)
- Patel L, "Resistin is expressed in human macrophages and directly regulated by PPAR gamma activat", Biochem Biophys Res Commun, 300, pp.472~476 (2003)
- Patel SD, "Disulfide-dependent multimeric assembly of resistin family hormones", Science, 304, pp.1154~1158 (2004)
- Tomaru T, "Adipocyte-specific expression of murine resistin is mediated by synergism between peroxisome proliferator-activated receptor gamma and CCAAT", enhancer-binding proteins, 2009, pp.284, 6116~6125
- Schwartz DR, "Human resistin: found in translation from mouse to man", Trends Endocrinol Metab, 22, pp.259~265 (2011)
- 박형규, "Resistin in Rodents and Humans", Diabetes and Metabolism Journal, 37(6), pp.404~414 (2013), 대한당뇨병학회[DOI]
- Novick D, "Heparanase interacts with resistin and augments its activity", PLoS One, 9, pp.e85944~ (2014)
- Lazar MA., "Resistin- and obesity-associated metabolic diseases", Horm Metab Res, 39, pp.710~716 (2007)
- Song R, "Resistin disrupts glycogen synthesis under high insulin and high glucose levels by down-regulating the hepatic levels of GSK3beta", Gene, 529, pp.50~56 (2013)
- Daquinag AC, "An isoform of decorin is a resistin receptor on the surface of adipose progenitor cells", Cell Stem Cell, 9, pp.74~86 (2011)
- Sanchez-Solana B, "Mouse resistin modulates adipogenesis and glucose uptake in 3T3-L1preadipocytes through the ROR1 receptor", Mol Endocrinol, 26, pp.110~127 (2012)
- Banerjee RR, "Regulation of fasted blood glucose by resistin", Science, 303, pp.1195~1198 (2004)
- Satoh H, "Adenovirus-mediated chronic “hyper-resistinemia”leads to in vivo insulin resistance in normal rats", J Clin Invest, 114, pp.224~231 (2004)
- Muse ED, "Role of resistin in diet-induced hepatic insulin resistance", J Clin Invest, 114, pp.232~239 (2004)
- Birnbaum MJ, "Activation of SOCS-3 by resistin", Mol Cell Biol, 25, pp.1569~1575 (2005)
- Filkova M, "The role of resistin as a regulator of inflammation: Implications for various human pathologies", Clin Immunol, 133, pp.157~170 (2009)
- Jamaluddin MS, "Resistin:functional roles and therapeutic considerations for cardiovascular disease", Br J Pharmacol, 165, pp.622~632 (2012)
- Bokarewa M, "Resistin, an adipokine with potent proinflammatory properties", J Immunol, 174, pp.5789~5795 (2005)
- Jung HS, "Resistin is secreted from macrophages in atheromas and promotes atherosclerosis", Cardiovasc Res, 69, pp.76~85 (2006)
- Hsu WY, "Resistin induces monocyte-endothelial cell adhesion by increasing ICAM-1 and VCAM-1 expression in endothelial cells via p38MAPK-dependent pathway", J Cell Physiol, 226, pp.2181~2188 (2011)
- Manduteanu I, "Similar effects of resistin and high glucose on P-selectin and fractalkine expression and monocyte adhesion in human endothelial cells", Biochem Biophys Res Commun, 391, pp.1443~1448 (2010)
- Jamaluddin MS, "Resistin increases monolayer permeability of human coronary artery endothelial cells", PLoS One, 8, pp.e84576~ (2013)
- Chen C, "Resistin decreases expression of endothelial nitric oxide synthase through oxidative stress in human coronary artery endothelial cells", Am J Physiol Heart Circ Physiol, 299, pp.H193~H201 (2010)
- Qiu W, "Resistin increases platelet P-selectin levels via p38 MAPK signal pathway", Diab Vasc Dis Res, 11, pp.121~124 (2014)
- Codoner-Franch P, "Resistin: insulin resistance to malignancy", Clin Chim Acta, 438, pp.46~54 (2015)
- Huang X, "Resistin’s, obesity and insulin resistance:the continuing disconnect between rodents and humans", J Endocrinol Invest, 39, pp.607~615 (2016)
- Qatanani M, "Macrophage-derived human resistin exacerbates adipose tissue inflammation and insulin resistance in mice", J Clin Invest, 119, pp.531~539 (2009)
- Park HK, "Inflammatory induction of human resistin causes insulin resistance in endotoxemic mice", Diabetes, 60, pp.775~783 (2011)
- Graveleau C, "Mouse and human resistins impair glucose transport in primary mouse cardiomyocytes, and oligomerization is required for this biological action", J Biol Chem, 280, pp.31679~31685 (2005)
- Sheng CH, "Human resistin inhibits myogenic differentiation and induces insulin resistance in myocytes", Biomed Res Int, 2013, pp.804632~ (2013)
- Luo Z, "Resistin induces insulin resistance by both AMPK-dependent and AMPK-independent mechanisms in HepG2 cells", Endocrine, 36, pp.60~69 (2009)
- Chen BH, "Circulating levels of resistin and risk of type 2 diabetes in men and women:results from two prospective cohorts", Diabetes Care, 32, pp.329~334 (2009)
- Tarkowski A, "Resistin competes with lipopolysaccharide for binding to toll-like receptor 4", J Cell Mol Med, 14(6B), pp.1419~1431 (2010)
- Lee S, "Adenylyl cyclase-associated protein 1 is a receptor for human resistin and mediates inflammatory actions of human monocytes", Cell Metab, 19, pp.484~497 (2014)
- Benomar Y, "Central resistin overexposure induces insulin resistance through Tolllike receptor 4", Diabetes, 62, pp.102~114 (2013)
- Ding Q, "Resistin and cardiovascular disease", Trends Cardiovasc Med, 21, pp.20~27 (2011)
- Lee SH, "Plasma adiponectin and resistin levels as predictors of mortality in patients with acute myocardial infarction: data from infarction prognosis study registry", Coron Artery Dis, 20, pp.33~39 (2009)
- Menzaghi C, "Serum resistin, cardiovascular disease and all-cause mortality in patients with type 2 diabetes", PLoS One, 8, pp.e64729~ (2014)
- Khera AV, "On-statin resistin, leptin, and risk of recurrent coronary events after hospitalization for an acute coronary syndrome (from the pravastatin or atorvastatin evaluation and infection therapy-thrombolysis in myocardial infarction 22 study)", Am J Cardiol, 116, pp.694~698 (2015)
- Wang BW, "Mechanical stretch enhances the expression of resistin gene in cultured cardiomyocytes via tumor necrosis factor-alpha", Am J Physiol Heart Circ Physiol, 293, pp.H2305~H2312 (2007)
- Chemaly ER, "Long-term in vivo resistin overexpression induces myocardial dysfunction and remodeling in rats", J Mol Cell Cardiol, 51, pp.144~155 (2011)
- Gao J, "Resistin, an adipocytokine, offers protection against acute myocardial infarction", J Mol Cell Cardiol, 43, pp.601~609 (2007)
- Rothwell SE, "Resistin worsens cardiac ischaemia-reperfusion injury", Biochem Biophys Res Commun, 349, pp.400~407 (2006)
- Schwartz DR, "Human resistin in chemotherapy-induced heart failure in humanized male mice and in women treated for breast cancer", Endocrinology, 154, pp.4206~4214 (2013)
- Menzaghi C, "Heritability of serum resistin and its genetic correlation with insulin resistance-related features in nondiabetic Caucasians", J Clin Endocrinol Metab, 91, pp.2792~2795 (2006)
- Osawa H, "Plasma resistin, associated with single nucleotide polymorphism -420, is correlated with insulin resistance, lower HDL cholesterol, and high-sensitivity C-reactive protein in the Japanese general population", Diabetes Care, 30, pp.1501~1506 (2007)
- Cho YM, "Common genetic polymorphisms in the promoter of resistin gene are major determinants of plasma resistin concentrations in humans", Diabetologia, 47, pp.559~565 (2004)
- Xu JY, "Resistin gene polymorphisms and progression of glycaemia in southern Chinese: a 5-year prospective study", Clin Endocrinol (Oxf ), 66, pp.211~217 (2007)
- El-Shal AS, "Association of resistin gene polymorphisms with insulin resistance in Egyptian obese patients", Gene, 515, pp.233~238 (2013)
- Norata GD, "Plasma resistin levels correlate with determinants of the metabolic syndrome", Eur J Endocrinol, 156, pp.279~284 (2007)
- Singh AK, "Association of resistin with metabolic syndrome in Indian subjects", Metab Syndr Relat Disord, 10, pp.286~291 (2012)
- Owecki M, "Serum resistin is related to plasma HDL cholesterol and inversely correlated with LDL cholesterol in diabetic and obese humans", Neuro Endocrinol Lett, 31, pp.673~678 (2010)
- Cabrera de Leon A, "Relationships between serum resistin and fat intake, serum lipid concentrations and adiposity in the general population", J Atheroscler Thromb, 21, pp.454~462 (2014)
- Abate N, "Resistin: an inflammatory cytokine: role in cardiovascular diseases, diabetes and the metabolic syndrome", Curr Pharm Des, 20, pp.4961~4969 (2014)
- Costandi J, "Human resistin stimulates hepatic overproduction of atherogenic ApoB-containing lipoprotein particles by enhancing ApoB stability and impairing intracellular insulin signaling", Circ Res, 108, pp.727~742 (2011)
- Rashid S, "PCSK9 and resistin at the crossroads of the atherogenic dyslipidemia", Expert Rev Cardiovasc Ther, 11, pp.1567~1577 (2013)
- Melone M, "Discovery of a new role of human resistin in hepatocyte low-density lipoprotein receptor suppression mediated in part by proprotein convertase subtilisin", kexin type 9, 2012, pp.59, 1697~1705
- Horton JD, "PCSK9: a convertase that coordinates LDL catabolism", J Lipid Res, 50(Suppl), pp.S172~S177 (2009)
- Hampton EN, "The self-inhibited structure of full-length PCSK9 at 1.9 A reveals structural homology with resistin within the C-terminal domain", Proc Natl Acad Sci U S A, 104, pp.14604~14609 (2007)
- Li S, "Relation of resistin to proprotein convertase subtilisin-kexin type 9 levels in coronary artery disease patients with different nutritional status", J Endocrinol Invest, 38, pp.1291~1299 (2015)
- Kosari S, "Centrally administered resistin enhances sympathetic nerve activity to the hindlimb but attenuates the activity to brown adipose tissue", Endocrinology, 152, pp.2626~2633 (2011)
- Badoer E, "Resistin, an adipokine with non-generalized actions on sympathetic nerve activity", Front Physiol, 6, pp.321~ (2015)
- Takata Y, "Hyperresistinemia is associated with coexistence of hypertension and type 2diabetes", Hypertension, 51, pp.534~539 (2008)
- Thomopoulos C, "Association of resistin and adiponectin with different clinical blood pressure phenotypes", J Hum Hypertens, 25, pp.38~46 (2011)
- Papadopoulos DP, "Adiponectin:insulin and resistin plasma levels in young healthy offspring of patients with essential hypertension", Blood Press, 17, pp.50~54 (2008)
- Zhang L, "Plasma resistin levels associate with risk for hypertension among nondiabetic women", J Am Soc Nephrol, 21, pp.1185~1191 (2010)
