Prognostic impact of hepatitis B or C on intrahepatic cholangiocarcinoma
0
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Background/Aims: Intrahepatic cholangiocarcinoma (ICC) is the second-most common primary liver malignancy, arising from the peripheral intrahepatic bile duct epithelium. Hepatitis B virus (HBV) or hepatitis C virus (HCV) may be involved in the development of ICC. We explored the prognostic value of hepatitis virus infection, as well as other prognostic factors affecting survival in patients with ICC. Methods: A retrospective chart review was performed for patients diagnosed with ICC between August 2005 and December 2018 at Konkuk University Medical Center. We identified a total of 131 patients with ICC. Overall survival rates of patients with and without hepatitis were determined. Univariate and multivariate analyses were used to estimate factors influencing survival outcomes. Results: A total of 17.6% (23/131) of patients were positive for HBV or HCV. Hepatitis B positive ICC patients were significantly younger with higher albumin and higher α-fetoprotein than those without hepatitis viral infections. The median survival of hepatitis-positive and hepatitis-negative groups was 280 and 213 days, respectively. Survival rates were not significantly different between the two groups (p = 0.279). Multivariate analyses indicated that lower serum carbohydrate antigen 19-9 (CA 19-9) (p < 0.001), lower T stage (p = 0.042), the absence of lymph-node metastasis (p = 0.043), and receiving curative surgery (p = 0.033) were independent predictors of better outcomes. Conclusions: While hepatitis influenced a number of clinical features in ICC patients, it did not affect survival rate. Prognostic factors influencing survival outcomes with ICC were CA 19-9 level, T stage, the presence of lymph node metastasis, and curative surgery.
Abstract
Background/Aims: Intrahepatic cholangiocarcinoma (ICC) is the second-most common primary liver malignancy, arising from the peripheral intrahepatic bile duct epithelium. Hepatitis B virus (HBV) or hepatitis C virus (HCV) may be involved in the development of ICC. We explored the prognostic value of hepatitis virus infection, as well as other prognostic factors affecting survival in patients with ICC. Methods: A retrospective chart review was performed for patients diagnosed with ICC between August 2005 and December 2018 at Konkuk University Medical Center. We identified a total of 131 patients with ICC. Overall survival rates of patients with and without hepatitis were determined. Univariate and multivariate analyses were used to estimate factors influencing survival outcomes. Results: A total of 17.6% (23/131) of patients were positive for HBV or HCV. Hepatitis B positive ICC patients were significantly younger with higher albumin and higher α-fetoprotein than those without hepatitis viral infections. The median survival of hepatitis-positive and hepatitis-negative groups was 280 and 213 days, respectively. Survival rates were not significantly different between the two groups (p = 0.279). Multivariate analyses indicated that lower serum carbohydrate antigen 19-9 (CA 19-9) (p < 0.001), lower T stage (p = 0.042), the absence of lymph-node metastasis (p = 0.043), and receiving curative surgery (p = 0.033) were independent predictors of better outcomes. Conclusions: While hepatitis influenced a number of clinical features in ICC patients, it did not affect survival rate. Prognostic factors influencing survival outcomes with ICC were CA 19-9 level, T stage, the presence of lymph node metastasis, and curative surgery.
참고문헌 (22)
- Zhang H, "Intrahepatic cholangiocarcinoma : epidemiology, risk factors, diagnosis and surgical management", Cancer Lett, 379, pp.198~205 (2016)
- Lafaro KJ, "Multidisciplinary care of patients with intrahepatic cholangiocarcinoma : updates in management", Gastroenterol Res Pract, 2015, pp.860861~ (2015)
- Bergquist A, "Epidemiology of cholangiocarcinoma", Best Pract Res Clin Gastroenterol, 29, pp.221~232 (2015)
- Zhou Y, "Hepatitis viruses infection and risk of intrahepatic cholangiocarcinoma : evidence from a meta-analysis", BMC Cancer, 12, pp.289~ (2012)
- Matsumoto K, "Hepatitis B and C virus infection is a risk factor for the development of cholangiocarcinoma", Intern Med, 53, pp.651~654 (2014)
- Wang Z, "Hepatitis B virus and hepatitis C virus play different prognostic roles in intrahepatic cholangiocarcinoma : a meta-analysis", World J Gastroenterol, 22, pp.3038~3051 (2016)
- Zhou HB, "Hepatitis B virus infection and intrahepatic cholangiocarcinoma", World J Gastroenterol, 20, pp.5721~5729 (2014)
- Lee TY, "Hepatitis B virus infection and intrahepatic cholangiocarcinoma in Korea : a case-control study", Am J Gastroenterol, 103, pp.1716~1720 (2008)
- Shimada M, "Highlights of topic Intrahepatic cholangiocarcinoma:recent advancements in pathogenesis, diagnosis and treatment", J Hepatobiliary Pancreat Sci, 22, pp.91~93 (2015)
- Dhanasekaran R, "Treatment outcomes and prognostic factors of intrahepatic cholangiocarcinoma", Oncol Rep, 29, pp.1259~1267 (2013)
- Lee CH, "Viral hepatitis-associated intrahepatic cholangiocarcinoma shares common disease processes with hepatocellular carcinoma", Br J Cancer, 100, pp.1765~1770 (2009)
- Perumal V, "Hepatitis C and hepatitis B nucleic acids are present in intrahepatic cholangiocarcinomas from the United States", Hum Pathol, 37, pp.1211~1216 (2006)
- Chen RF, "Effect of hepatitis C virus core protein on modulation of cellular proliferation and apoptosis in hilar cholangiocarcinoma", Hepatobiliary Pancreat Dis Int, 4, pp.71~74 (2005)
- Torbenson M, "Bile duct dysplasia in the setting of chronic hepatitis C and alcohol cirrhosis", Am J Surg Pathol, 31, pp.1410~1413 (2007)
- Zhou H, "Hepatitis B virus-associated intrahepatic cholangiocarcinoma and hepatocellular carcinoma may hold common disease process for carcinogenesis", Eur J Cancer, 46, pp.1056~1061 (2010)
- Wu ZF, "Characteristics of intrahepatic cholangiocarcinoma in patients with hepatitis B virus infection : clinicopathologic study of resected tumours", J Viral Hepat, 20, pp.306~310 (2013)
- Hanazaki K, "Prognostic factors of intrahepatic cholangiocarcinoma after hepatic resection : univariate and multivariate analysis", Hepatogastroenterology, 49, pp.311~316 (2002)
- Kawarada Y, "Analysis of the relationships between clinicopathologic factors and survival time in intrahepatic cholangiocarcinoma", Am J Surg, 183, pp.679~685 (2002)
- 송기원, "단일 센터에서 진단된 간내담관암종 318예의 생존율 및 생존율에 영향을 미치는 인자들에 대한 분석", Clinical and Molecular Hepatology, 13(2), pp.208~221 (2007), 대한간학회
- Endo I, "Intrahepatic cholangiocarcinoma : rising frequency, improved survival, and determinants of outcome after resection", Ann Surg, 248, pp.84~96 (2008)
- Shirai K, "Perineural invasion is a prognostic factor in intrahepatic cholangiocarcinoma", World J Surg, 32, pp.2395~2402 (2008)
- Yuan L, "Comparison of clinicopathological characteristics between cirrhotic and non-cirrhotic patients with intrahepatic cholangiocarcinoma : a largescale retrospective study", Mol Clin Oncol, 7, pp.615~622 (2017)