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Squamous cell carcinoma of head and neck: what internists should know

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Squamous cell carcinoma of head and neck (SCCHN) is a group of cancer arising from mucosal surfaces of the head and neck. Optimal management of SCCHN requires a multidisciplinary team of surgical oncologists, radiation oncologists, medical oncologists, nutritionist, and speech-language pathologists, due to the complexity of anatomical structure and importance of functional outcome. Human papilloma virus (HPV)-related SCCHN represents a distinct subset from HPV negative SCCHN which is associated with carcinogen exposure such as cigarette smoking, betel nut use and alcohol. HPV related SCCHN responds better to concurrent chemoradiation and has better overall prognosis, compared to HPV negative SCCHN. Radiation therapy has been introduced to the treatment of SCCHN, administered concurrently with systemic chemotherapy for locoregional SCCHN, as well as a palliative measure for recurrent and/or metastatic (R/M) SCCHN. Recently, immune checkpoint inhibitors have been shown to improve overall survival in R/M-SCCHN and have been incorporated into the standard of care. Combination approaches with immune therapy and targeted therapy for biomarker enriched population based on genomics are being actively investigated and will shape the future of SCCHN treatment.

Abstract

Squamous cell carcinoma of head and neck (SCCHN) is a group of cancer arising from mucosal surfaces of the head and neck. Optimal management of SCCHN requires a multidisciplinary team of surgical oncologists, radiation oncologists, medical oncologists, nutritionist, and speech-language pathologists, due to the complexity of anatomical structure and importance of functional outcome. Human papilloma virus (HPV)-related SCCHN represents a distinct subset from HPV negative SCCHN which is associated with carcinogen exposure such as cigarette smoking, betel nut use and alcohol. HPV related SCCHN responds better to concurrent chemoradiation and has better overall prognosis, compared to HPV negative SCCHN. Radiation therapy has been introduced to the treatment of SCCHN, administered concurrently with systemic chemotherapy for locoregional SCCHN, as well as a palliative measure for recurrent and/or metastatic (R/M) SCCHN. Recently, immune checkpoint inhibitors have been shown to improve overall survival in R/M-SCCHN and have been incorporated into the standard of care. Combination approaches with immune therapy and targeted therapy for biomarker enriched population based on genomics are being actively investigated and will shape the future of SCCHN treatment.

참고문헌 (96)

  1. Walden MJ, "Head and neck cancer", Semin Roentgenol, 48, pp.75~86 (2013)
  2. Siegel RL, "Cancer statistics, 2019", CA Cancer J Clin, 69, pp.7~34 (2019)
  3. 정규원, "Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2015", Cancer Research and Treatment, 50(2), pp.303~316 (2018), 대한암학회
  4. Goldenberg D, "Habitual risk factors for head and neck cancer", Otolaryngol Head Neck Surg, 131, pp.986~993 (2004)
  5. Maier H, "Tobacco and alcohol and the risk of head and neck cancer", Clin Investig, 70, pp.320~327 (1992)
  6. Kutler DI, "High incidence of head and neck squamous cell carcinoma in patients with Fanconi anemia", Arch Otolaryngol Head Neck Surg, 129, pp.106~112 (2003)
  7. D’Souza G, "Case-control study of human papillomavirus and oropharyngeal cancer", N Engl J Med, 356, pp.1944~1956 (2007)
  8. Ang KK, "Human papillomavirus and survival of patients with oropharyngeal cancer", N Engl J Med, 363, pp.24~35 (2010)
  9. Fakhry C, "Human papillomavirus and overall survival after progression of oropharyngeal squamous cell carcinoma", J Clin Oncol, 32, pp.3365~3373 (2014)
  10. Gillison ML, "Prevalence of oral HPV infection in the United States, 2009-2010", JAMA, 307, pp.693~703 (2012)
  11. Sonawane K, "Oral human papillomavirus infection : differences in prevalence between sexes and concordance with genital human papillomavirus infection, NHANES 2011 to 2014", Ann Intern Med, 167, pp.714~724 (2017)
  12. Gillison ML, "Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers", J Natl Cancer Inst, 100, pp.407~420 (2008)
  13. Mork J, "Human papillomavirus infection as a risk factor for squamous-cell carcinoma of the head and neck", N Engl J Med, 344, pp.1125~1131 (2001)
  14. Kim YT, "Burden of human papillomavirus(HPV)-related disease and potential impact of HPV vaccines in the Republic of Korea", Papillomavirus Res, 7, pp.26~42 (2019)
  15. Smith EM, "Age, sexual behavior and human papillomavirus infection in oral cavity and oropharyngeal cancers", Int J Cancer, 108, pp.766~772 (2004)
  16. Anaya-Saavedra G, "High association of human papillomavirus infection with oral cancer : a case-control study", Arch Med Res, 39, pp.189~197 (2008)
  17. Chaturvedi AK, "Effect of prophylactic human papillomavirus(HPV)vaccination on oral HPV infections among young adults in the United States", J Clin Oncol, 36, pp.262~267 (2018)
  18. Mittal S, "Molecular mechanisms underlying human papillomavirus E6 and E7 oncoprotein-induced cell transformation", Mutat Res Rev Mutat Res, 772, pp.23~35 (2017)
  19. Ertosun MG, "E2F1 transcription factor and its impact on growth factor and cytokine signaling", Cytokine Growth Factor Rev, 31, pp.17~25 (2016)
  20. Ho GY, "Natural history of cervicovaginal papillomavirus infection in young women", N Engl J Med, 338, pp.423~428 (1998)
  21. zur Hausen H, "Papillomaviruses causing cancer : evasion from host-cell control in early events in carcinogenesis", J Natl Cancer Inst, 92, pp.690~698 (2000)
  22. McLaughlin-Drubin ME, "Human papillomavirus E7 oncoprotein induces KDM6A and KDM6B histone demethylase expression and causes epigenetic reprogramming", Proc Natl Acad Sci U S A, 108, pp.2130~2135 (2011)
  23. Prigge ES, "Diagnostic accuracy of p16INK4a immunohistochemistry in oropharyngeal squamous cell carcinomas : a systematic review and meta-analysis", Int J Cancer, 140, pp.1186~1198 (2017)
  24. Randen-Brady R, "In situ hybridization for high-risk HPV E6", E7 mRNA is a superior method for detecting transcriptionally active HPV in oropharyngeal cancer, 2019, pp.90, 97~105
  25. Cancer Genome Atlas Network, "Comprehensive genomic characterization of head and neck squamous cell carcinomas", Nature, 517, pp.576~582 (2015)
  26. Oganesyan G, "Critical role of TRAF3in the Toll-like receptor-dependent and-independent antiviral response", Nature, 439, pp.208~211 (2006)
  27. Koncar RF, "Comparative molecular profiling of HPV-induced squamous cell carcinomas", Cancer Med, 6, pp.1673~1685 (2017)
  28. Lee JY, "Biochemistry. PI3K charges ahead", Science, 317, pp.206~207 (2007)
  29. Scheid MP, "PKB", AKT : functional insights from genetic models, 2001, pp.2, 760~768
  30. Nichols AC, "High frequency of activating PIK3CA mutations in human papillomavirus-positive oropharyngeal cancer", JAMA Otolaryngol Head Neck Surg, 139, pp.617~622 (2013)
  31. Jung K, "Targeting phosphoinositide 3-kinase(PI3K)in head and neck squamous cell carcinoma(HNSCC)", Cancers Head Neck, 3, pp.3~ (2018)
  32. Chung CH, "p16 protein expression and human papillomavirus status as prognostic biomarkers of nonoropharyngeal head and neck squamous cell carcinoma", J Clin Oncol, 32, pp.3930~3938 (2014)
  33. Butz K, "Cellular responses of HPV-positive cancer cells to genotoxic anti-cancer agents : repression of E6", E7-oncogene expression and induction of apoptosis, 1996, pp.68, 506~513
  34. Liu Y, "Human papillomavirus type 16 E6 and HPV-16 E6", E7 sensitize human keratinocytes to apoptosis induced by chemotherapeutic agents : roles of p53 and caspase activation, 2000, pp.78, 334~349
  35. Marur S, "Head and neck squamous cell carcinoma : update on epidemiology, diagnosis, and treatment", Mayo Clin Proc, 91, pp.386~396 (2016)
  36. Zhang H, "Survival outcomes of patients with advanced oral cavity squamous cell carcinoma treated with multimodal therapy : a multi-institutional analysis", J Otolaryngol Head Neck Surg, 42, pp.30~ (2013)
  37. Nichols AC, "Radiotherapy versus transoral robotic surgery and neck dissection for oropharyngeal squamous cell carcinoma(ORATOR) : an open-label, phase 2, randomised trial", Lancet Oncol, 20, pp.1349~1359 (2019)
  38. Richmond RC, "Radiation sensitization of bacterial spores by cis-dichlorodiammineplatinum(II)", Radiat Res, 68, pp.251~257 (1976)
  39. Wallner KE, "Effect of cisplatin resistance on cellular radiation response", Int J Radiat Oncol Biol Phys, 13, pp.587~591 (1987)
  40. Calais G, "Randomized trial of radiation therapy versus concomitant chemotherapy and radiation therapy for advanced-stage oropharynx carcinoma", J Natl Cancer Inst, 91, pp.2081~2086 (1999)
  41. Denis F, "Final results of the 94-01 French Head and Neck Oncology and Radiotherapy Group randomized trial comparing radiotherapy alone with concomitant radiochemotherapy in advanced-stage oropharynx carcinoma", J Clin Oncol, 22, pp.69~76 (2004)
  42. Adelstein DJ, "An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer", J Clin Oncol, 21, pp.92~98 (2003)
  43. Forastiere AA, "Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer", N Engl J Med, 349, pp.2091~2098 (2003)
  44. Wendt TG, "Simultaneous radiochemotherapy versus radiotherapy alone in advanced head and neck cancer : a randomized multicenter study", J Clin Oncol, 16, pp.1318~1324 (1998)
  45. Forastiere AA, "Long-term results of RTOG 91-11 : a comparison of three nonsurgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer", J Clin Oncol, 31, pp.845~852 (2013)
  46. Bernier J, "Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer", N Engl J Med, 350, pp.1945~1952 (2004)
  47. Cooper JS, "Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck", N Engl J Med, 350, pp.1937~1944 (2004)
  48. Haddad R, "Induction chemotherapy followed by concurrent chemoradiotherapy (sequential chemoradiotherapy) versus concurrent chemoradiotherapy alone in locally advanced head and neck cancer (PARADIGM): a randomised phase 3 trial", Lancet Oncol, 14, pp.257~264 (2013)
  49. Cohen EE, "Phase III randomized trial of induction chemotherapy in patients with N2 or N3 locally advanced head and neck cancer", J Clin Oncol, 32, pp.2735~2743 (2014)
  50. Geoffrois L, "Induction chemotherapy followed by cetuximab radiotherapy is not superior to concurrent chemoradiotherapy for head and neck carcinomas : results of the GORTEC 2007-02 phase III randomized trial", J Clin Oncol, 36, pp.3077~3083 (2018)
  51. Zhong LP, "Randomized phase III trial of induction chemotherapy with docetaxel, cisplatin, and fluorouracil followed by surgery versus up-front surgery in locally advanced resectable oral squamous cell carcinoma", J Clin Oncol, 31, pp.744~751 (2013)
  52. Bonner JA, "Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck", N Engl J Med, 354, pp.567~578 (2006)
  53. Gillison ML, "Radiotherapy plus cetuximab or cisplatin in human papillomavirus-positive oropharyngeal cancer (NRG Oncology RTOG 1016):a randomised, multicentre, non-inferiority trial", Lancet, 393, pp.40~50 (2019)
  54. Mehanna H, "Radiotherapy plus cisplatin or cetuximab in low-risk human papillomavirus-positive oropharyngeal cancer(De-ESCALaTE HPV) : an open-label randomised controlled phase 3 trial", Lancet, 393, pp.51~60 (2019)
  55. Tan HK, "Salvage surgery after concomitant chemoradiation in head and neck squamous cell carcinomas : stratification for postsalvage survival", Head Neck, 32, pp.139~147 (2010)
  56. Guo T, "Surgical salvage improves overall survival for patients with HPV-positive and HPV-negative recurrent locoregional and distant metastatic oropharyngeal cancer", Cancer, 121, pp.1977~1984 (2015)
  57. Argiris A, "Prognostic significance of human papillomavirus in recurrent or metastatic head and neck cancer : an analysis of Eastern Cooperative Oncology Group trials", Ann Oncol, 25, pp.1410~1416 (2014)
  58. Joseph AW, "Disease-free survival after salvage therapy for recurrent oropharyngeal squamous cell carcinoma", Head Neck, 38(Suppl 1), pp.E1501~E1509 (2016)
  59. Vermorken JB, "Platinum-based chemotherapy plus cetuximab in head and neck cancer", N Engl J Med, 359, pp.1116~1127 (2008)
  60. Vermorken JB, "Overview of the efficacy of cetuximab in recurrent and", or metastatic squamous cell carcinoma of the head and neck in patients who previously failed platinum-based therapies, 2008, pp.112, 2710~2719
  61. Francisco LM, "PD-L1 regulates the development, maintenance, and function of induced regulatory T cells", J Exp Med, 206, pp.3015~3029 (2009)
  62. Amarnath S, "The PDL1-PD1axis converts human TH1 cells into regulatory T cells", Sci Transl Med, 3, pp.111~120 (2011)
  63. Bauml J, "Pembrolizumab for platinum-and cetuximab-refractory head and neck cancer : results from a single-arm, phase II study", J Clin Oncol, 35, pp.1542~1549 (2017)
  64. Ferris RL, "Nivolumab for recurrent squamous-cell carcinoma of the head and neck", N Engl J Med, 375, pp.1856~1867 (2016)
  65. Harrington KJ, "Nivolumab versus standard, single-agent therapy of investigator’s choice in recurrent or metastatic squamous cell carcinoma of the head and neck (CheckMate 141):health-related quality-of-life results from a randomised, phase 3 trial", Lancet Oncol, 18, pp.1104~1115 (2017)
  66. Burtness B, "Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study", Lancet, 394, pp.1915~1928 (2019)
  67. Pestana RC, "Response rates and survival to systemic therapy after immune checkpoint inhibitor failure in recurrent", metastatic head and neck squamous cell carcinoma, 2020, pp.101, 104523~
  68. Murphy BA, "Advances in supportive care for late effects of head and neck cancer", J Clin Oncol, 33, pp.3314~3321 (2015)
  69. Weber RS, "Outcome of salvage total laryngectomy following organ preservation therapy: the Radiation Therapy Oncology Group trial 91-11", Arch Otolaryngol Head Neck Surg, 129, pp.44~49 (2003)
  70. van der Woerd B, "Functional outcomes in early(T1", T2)supraglottic cancer : a systematic review, 2018, pp.47, 76~
  71. Kumarasiri A, "Changes in pharyngeal constrictor volumes during head and neck radiation therapy : implications for dose delivery", J Cancer Res Ther, 13, pp.218~223 (2017)
  72. Jacobi I, "Radiation dose to the tongue and velopharynx predicts acoustic-articulatory changes after chemo-IMRT treatment for advanced head and neck cancer", Eur Arch Otorhinolaryngol, 273, pp.487~494 (2016)
  73. Starmer HM, "Swallowing outcomes in patients with oropharyngeal cancer undergoing organ-preservation treatment", Head Neck, 36, pp.1392~1397 (2014)
  74. Fung K, "Voice and swallowing outcomes of an organ-preservation trial for advanced laryngeal cancer", Int J Radiat Oncol Biol Phys, 63, pp.1395~1399 (2005)
  75. Kirsh E, "Patient-reported versus physiologic swallowing outcomes in patients with head and neck cancer after chemoradiation", Laryngoscope, 129, pp.2059~2064 (2019)
  76. McClelland S 3rd, "Prophylactic versus reactive gastrostomy tube placement in advanced head and neck cancer treated with definitive chemoradiotherapy : a systematic review", Oral Oncol, 87, pp.77~81 (2018)
  77. Lambert L, "Organ preservation with concurrent chemoradiation for advanced laryngeal cancer : are we succeeding", Int J Radiat Oncol Biol Phys, 76, pp.398~402 (2010)
  78. Grundmann O, "Sensitivity of salivary glands to radiation : from animal models to therapies. Version 2", J Dent Res, 88, pp.894~903 (2009)
  79. Hong CH, "A systematic review of dental disease in patients undergoing cancer therapy", Support Care Cancer, 18, pp.1007~1021 (2010)
  80. Deng J, "Dental demineralization and caries in patients with head and neck cancer", Oral Oncol, 51, pp.824~831 (2015)
  81. Epstein JB, "Oral complications of cancer and cancer therapy : from cancer treatment to survivorship", CA Cancer J Clin, 62, pp.400~422 (2012)
  82. Benson E, "The clinical impact of HPV tumor status upon head and neck squamous cell carcinomas", Oral Oncol, 50, pp.565~574 (2014)
  83. Rogers SN, "The development of a patients concerns inventory(PCI)to help reveal patients concerns in the head and neck clinic", Oral Oncol, 45, pp.555~561 (2009)
  84. Cohen EE, "American Cancer Society head and neck cancer survivorship care guideline", CA Cancer J Clin, 66, pp.203~239 (2016)
  85. Pinto FR, "Tobacco and alcohol use after head and neck cancer treatment: influence of the type of oncological treatment employed", Rev Assoc Med Bras, 57, pp.171~176 (2011)
  86. Chen AM, "Tobacco use among long-term survivors of head and neck cancer treated with radiation therapy", Psychooncology, 23, pp.190~194 (2014)
  87. Gritz ER, "First year after head and neck cancer : quality of life", J Clin Oncol, 17, pp.352~360 (1999)
  88. Funk GF, "Long-term health-related quality of life in survivors of head and neck cancer", Arch Otolaryngol Head Neck Surg, 138, pp.123~133 (2012)
  89. Chen AM, "Depression among long-term survivors of head and neck cancer treated with radiation therapy", JAMA Otolaryngol Head Neck Surg, 139, pp.885~889 (2013)
  90. Mitchell AJ, "Depression and anxiety in long-term cancer survivors compared with spouses and healthy controls : a systematic review and meta-analysis", Lancet Oncol, 14, pp.721~732 (2013)
  91. Shinn EH, "Depression and oropharynx cancer outcome", Psychosom Med, 78, pp.38~48 (2016)
  92. Marur S, "E1308: phase II trial of induction chemotherapy followed by reduced-dose radiation and weekly cetuximab in patients with HPV-associated resectable squamous cell carcinoma of the oropharynx. ECOG-ACRIN Cancer Research Group", J Clin Oncol, 35, pp.490~497 (2017)
  93. Yom SS, "NRG-HN002 : a randomized phase II trial for patients with p16-positive, non-smoking-associated, locoregionally advanced oropharyngeal cancer", Int J Radiat Oncol Biol Phys, 105, pp.684~685 (2019)
  94. Massarelli E, "Combining immune checkpoint blockade and tumor-specific vaccine for patients with incurable human papillomavirus 16-related cancer: a phase 2 clinical trial", JAMA Oncol, 5, pp.67~73 (2019)
  95. Ho A, "Abstract PR08: preliminary results from a phase 2 trial of tipifarnib in squamous cell carcinomas (SCCs) with HRAS mutations", Mol Cancer Ther, 18(12 Suppl), pp.PR08~ (2019)
  96. Anderson CM, "Phase IIb, randomized, double-blind trial of GC4419 versus placebo to reduce severe oral mucositis due to concurrent radiotherapy and cisplatin for head and neck cancer", J Clin Oncol, 37, pp.3256~3265 (2019)

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