본문 바로가기
KERD
논문KCI 등재

Lack of Association of Glutathione S-transferase P1 Ile105Val Polymorphism with Aspirin-Intolerant Asthma

김승현|박춘식|박해심|남동호|신형두|서창희|오정미|Young Mok Lee|June Hyuk Lee
대한내과학회 (The Korean Association Of Internal Medicine)|2005.09|The Korean Journal of Internal Medicine|제20권 제3호|pp. 232-236

1

조회

0

다운로드

0

인용

0

참고문헌

주제분류내과학

초록

Abstract

Background : Glutathion S-transferase P1 (GSTP1), the abundant isoform of glutathione S-transferase in lung epithelium, plays an important role in cellular protection against oxidative stress and toxic foreign chemicals. GSTP1 (Ile105Val) polymorphism has been reported to be associated with asthma related phenotypes such as atopy and bronchial hyperresponsiveness. Therefore we investigated whether this polymorphism may be associated with the development of aspirin-intolerant asthma (AIA). Methods : GSTP1 Ile105Val polymorphism was determined using a single based extension method in 88 AIA subjects and compared to 154 aspirin-tolerant asthma (ATA) subjects and 119 normal healthy controls (NC) recruited from the Korean population. Results : No significant differences in allele and genotype frequencies of the GSTP1 Ilel105Val polymorphism were observed in the three groups (p>0.05). However, minor G allele frequency of the GSTP1 Ilel105Val polymorphism in AIA group (16.5%) tended to be lower than in the NC group (20.6%). Conclusion : These results suggest a lack of association of the GSTPI Ilel105Val gene polymorphism with AIA phenotype in the Korean population [word count: 159].

참고문헌 (23)

  1. "Carillo T. Intolerance to non-steroidal anti-inflammatory drugs results of controlled drug challenges in 98 patients.", 98, pp.678~685 (1996)
  2. "Overexpression of leukotriene C4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma.", 101, pp.834~846 (1998)
  3. "Inflammatory cell populations in bronchial biopsies from aspirin-sensitive asthmatic subjects.", 153, pp.90~96 (1996)
  4. "Effect of endobronchial aspirin challenge on inflammatory cells in bronchial biopsy samples from aspirin sensitive asthmatic subjects.", 51, pp.64~70 (1996)
  5. "Leukotriene C4 synthase promoter polymorphism and risk of aspirin-induced asthma.", 350, pp.1599~1600 (1997)
  6. "Polymorphisms at the glutathione S-transferase, GSTP1 locus: a novel mechanism for susceptibility and development of atopic airway inflammation.", 55, pp.15~20 (2000)
  7. "Potential contribution of the glutathione S-transferase supergene family to resistance to oxidative stress.", 22, pp.193~207 (1995)
  8. "The candidate region approach to the genetics of asthma and allergy.", 156, pp.144~151 (1997)
  9. "The Collaborative Study on the Genetics of Asthma. A genome- wide search for asthma susceptibility loci in ethnically diverse populations.", 15, pp.389~392 (1997)
  10. "A genome-wide search for quantitative trait loci underlying asthma.", 383, pp.247~250 (1996)
  11. "Allelic association of gene markers on chromosome 5q and 11q with atopy and bronchial hyperresponsiveness.", 153, pp.1280~1284 (1996)
  12. "Polymorphism at the glutathione S-transferase GSTP1 locus a new marker for bronchial hyperresponsiveness and asthma.", 161, pp.1437~1442 (2000)
  13. "Glutathione S-transferase GSTP1 is a susceptibility gene for occupational asthma induced by isocyanates.", 109, pp.867~872 (2002)
  14. "Molecular structure at 1.8 A of mouse liver class pi glutathione S-transferase complexed with S-", pp.298~314 (1994)
  15. ". Naturally occurring human glutathione S-transferase GSTP1-1 isoforms with isoleucine and valine in position 104 differ in enzymic properties. Eur J Biochem 224", pp.893~899 (1994)
  16. ". Lekotriene related gene polymorphisms in ASA-intolerant asthma an association with a haplotype of 5-lipoxygense.", 114, pp.337~344 (2004)
  17. "Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate.", 3, pp.717~727 (1995)
  18. "Bell DA. Ethnic variation in the CYP2E1 gene polymorphism analysis of 695 African-Americans"
  19. "Association of polymorphism in glutathione S-transferase loci with susceptibility and outcome in rheumatoid arthritis comparison with the shared epitope.", 58, pp.164~168 (1999)
  20. "Glutathione S-transferase GSTP1 and cyclin D1 genotypes: associations with numbers of basal cell carcinomas in a patient subgroup at high-risk of multiple tumors.", 10, pp.545~556 (2000)
  21. "Human glutathione S-transferase P1 polymorphisms relationship to lung tissue enzyme activity and population frequency distribution.", 19, pp.275~280 (1998)
  22. "transferase P1 (GSTP1) polymorphism in patients with chronic obstructive pulmonary disease.", 54, pp.693~696 (1999)
  23. "Diet as a risk factor for asthma.", 206, pp.244~257 (1997)

관련 논문AI추천

Leukotriene C4 Synthase 유전자 Promoter 부위 유전적 다형과 아스피린 과민성 천식의 연관성김상헌, 김선신, 김유영, 김윤근, 민경업, 박흥우, 반준우, 손성욱, 신은순, 오선영, 이상민, 이종은, 장윤석, 조상헌대한천식알레르기학회 · 천식 및 알레르기2006 · 제26권 제2호아스피린 과민성 천식에서 류코트리엔의 생합성에 관여하는 효소들과 그 수용체의 단일염기다형 및 5-lipoxygenase 일배체형 분석박춘식, 박해심, 서유진, 신승수, 신형두, 오흥범, 이준혁, 최정희대한천식알레르기학회 · 천식 및 알레르기2003 · 제23권 제4호Clinical Implications of Single Nucleotide Polymorphisms in Diagnosis of Asthma and its Subtypes박종숙, 박춘식, 손지혜, 장헌수연세대학교의과대학 · Yonsei Medical Journal2019 · 제60권 제1호Association of PTGER gene family polymorphisms with aspirin intolerant asthma in Korean asthmatics김미경, 김용훈, 박병래, 박세민, 박종숙, 박춘식, 신형두, 어수택, 이재영, 최병휘, 최인선, 홍천수, Jae-Sung Choi, Sang-Heon Cho, Yong-Won Lee생화학분자생물학회 · BMB Reports2010 · 제43권 제6호알레르기비염 환자에서 Glutathione S-Transferase P1유전자의 다형성에 관한 연구김선태, 유정국, 이은정, 정유삼, 최진호, 황규성, 황유진대한이비인후과학회 · 대한이비인후과학회지 두경부외과학2005 · 제48권 제6호Association of β2-Adrenergic Receptor Polymorphism with the Phenotype of Aspirin- Intolerant Acute Urticaria김승현, 김현아, 박해심, 예영민, 허규영연세대학교의과대학 · Yonsei Medical Journal2007 · 제48권 제6호

이 간행물의 다른 논문 (8건)

High-dose Versus Low-dose Cyclophosphamide in Combination with G-CSF for Peripheral Blood Progenitor Cell MobilizationJin Seok Ahn, Chu Myung Seong, Myung Ju Ahn, 조은경, 김철수, 이문희, 윤성수, 이종석, 김병국, 이근석, 정철원, 박선양, 방수미, 임석아, Jung Ae Lee, Jae Hoon Lee, Hugh Chul Kimpp. 224-231Double Autologous Stem Cell Transplantation for Multiple Myeloma: A Korean Single Center Study김신, 서철원, 이정신, 전민혁, 윤순만, 김상위, 심혁, 김우건, 이정훈, 고옥배, 도일노, 이소영, 김상희, 안정민, 지현숙, 박찬정, 김성배, 김용길pp. 237-242Delayed Ventricular Septal Rupture after Percutaneous Coronary Intervention in Acute Myocardial InfarctionSi Hoon Park, Yu Hyun Lee, In Je Kim, Seong Hoon Park, Ji Young Park, Ki Hwan Kwon, Ji Young Ohpp. 243-246A Case of Uterine Cervical Cancer Presenting with GranulocytosisBaek Yeol Ryoo, Heui June Ahn, Sun Hoo Park, Min Suk Kim, Yeon Hee Park, Yoon Hwan Chang, Sung Hyun Yangpp. 247-250Congenital Double-Orifice Mitral Valve with Mitral Regurgitation due to Flail Leaflet in an Elderly PatientShin Jae Kim, Sang Gon Lee, Eun Seok Shinpp. 251-254
원문 보기