Two Lung Masses with Different Responses to Pemetrexed
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We described here a patient who had two lung masses. Although the two masses had the same histology and a similar good response to initial chemotherapy with gemcitabine and carboplatin, the response to pemetrexed as a second-line treatment was different after re-growth of the tumors. These two lung masses could have originated from different clones or they could have progressed through different paths of molecular pathogenesis after metastasis, which would lead to different tumor characteristics, including their chemosensitivity. Regardless of their pathogenetic mechanisms, it seems important to recognize that tumors with the same histology that develop in one patient can have different responses to drugs. (Korean J Intern Med 2010;25:213-216)
Abstract
We described here a patient who had two lung masses. Although the two masses had the same histology and a similar good response to initial chemotherapy with gemcitabine and carboplatin, the response to pemetrexed as a second-line treatment was different after re-growth of the tumors. These two lung masses could have originated from different clones or they could have progressed through different paths of molecular pathogenesis after metastasis, which would lead to different tumor characteristics, including their chemosensitivity. Regardless of their pathogenetic mechanisms, it seems important to recognize that tumors with the same histology that develop in one patient can have different responses to drugs. (Korean J Intern Med 2010;25:213-216)
참고문헌 (11)
- Ferguson MK, "Diagnosis and management of synchronous lung cancers", J Thorac Cardiovasc Surg, 89, pp.378~385 (1985)
- Kinoshita I, "Intrapulmonary metastasis in resected cases of pulmonary carcinoma", Nippon Kyobu Geka Gakkai Zasshi, 31, pp.2020~2026 (1983)
- Martini N, "Multiple primary lung cancers", J Thorac Cardiovasc Surg, 70, pp.606~612 (1975)
- Mathisen DJ, "Survival following resection for second and third primary lung cancers", J Thorac Cardiovasc Surg, 88, pp.502~510 (1984)
- Carey FA, "Synchronous primary lung cancers: prevalence in surgical material and clinical implications", Thorax, 48, pp.344~346 (1993)
- Ryoo BY, "Synchronous multiple primary lung cancers with different response to gefitinib", Lung Cancer, 53, pp.245~248 (2006)
- Hanna N, "Randomized phase III trial of pemetrexed versus docetaxel in patients with non-smallcell lung cancer previously treated with chemotherapy", J Clin Oncol, 22, pp.1589~1597 (2004)
- Hanauske AR, "In vitro chemosensitivity of freshly explanted tumor cells to pemetrexed is correlated with target gene expression", Invest New Drugs, 25, pp.417~423 (2007)
- Nakatsu N, "Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays", Mol Cancer Ther, 4, pp.399~412 (2005)
- Kobayashi H, "Development of a new in vitro chemosensitivity test using collagen gel droplet embedded culture and image analysis for clinical usefulness", Recent Results Cancer Res, 161, pp.48~61 (2003)
- Ma Y, "Predicting cancer drug response by proteomic profiling", Clin Cancer Res, 12, pp.4583~4589 (2006)