Successful Treatment of Stereotactic Body Radiation Therapy Combined with Transarterial Chemolipiodolization for Hepatocellular Carcinoma with Biliary Obstruction
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Conventional radiation therapy (RT) is a widely recognized treatment for hepatocellular carcinoma (HCC). However, conventional RT plays only a limited role in HCC treatment because of its low efficacy and the low tolerance of the liver for this modality. Stereotactic body radiation therapy (SBRT) was recently developed and represents the most advanced radiation therapy technique currently available. It can deliver a high dose in a short time to well-defined hepatic tumors, with rapid dose fall-off gradients. We believe that SBRT with transarterial chemolipiodolization (TACL) may prove promising as a combined treatment modality for HCC due to its precision and relative safety. Here we present a case of successful treatment of advanced HCC with obstructive jaundice using this combined modality.
Abstract
Conventional radiation therapy (RT) is a widely recognized treatment for hepatocellular carcinoma (HCC). However, conventional RT plays only a limited role in HCC treatment because of its low efficacy and the low tolerance of the liver for this modality. Stereotactic body radiation therapy (SBRT) was recently developed and represents the most advanced radiation therapy technique currently available. It can deliver a high dose in a short time to well-defined hepatic tumors, with rapid dose fall-off gradients. We believe that SBRT with transarterial chemolipiodolization (TACL) may prove promising as a combined treatment modality for HCC due to its precision and relative safety. Here we present a case of successful treatment of advanced HCC with obstructive jaundice using this combined modality.
참고문헌 (14)
- Park HC, "Doseresponse relationship in local radiotherapy for hepatocellular carcinoma", Int J Radiat Oncol Biol Phys, 54, pp.150~155 (2002)
- Herfarth KK, "Stereotactic single-dose radiation therapy of liver tumors: results of a phase I", II trial, 2001, pp.19, 164~170
- Kwon JH, "Long-term effect of stereotactic body radiation therapy for primary hepatocellular carcinoma ineligible for local ablation therapy or surgical resection. Stereotactic radiotherapy for liver cancer", BMC Cancer, 10, pp.475~484 (2010)
- Seong J, "Combined transcatheter arterial chemoembolization and local radiotherapy of unresectable hepatocellular carcinoma", INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 43, pp.393~397 (1999)
- Han KH, "Liver cancer in Korea", Hepatol Res, 37(2), pp.106~109 (2007)
- Lau WY, "Obstructive jaundice secondary to hepatocellular carcinoma", Surg Oncol, 4, pp.303~308 (1995)
- Mallory TB, "Case records of the Massachusetts General Hospital Case", N Engl J Med, 237, pp.673~678 (1947)
- Lai EC, "Hepatocellular carcinoma presenting with obstructive jaundice", ANZ J Surg, 76, pp.631~636 (2006)
- Lau W, "A logical approach to hepatocellular carcinoma presenting with jaundice", Ann Surg, 225, pp.281~285 (1997)
- Yamada K, "Prospective trial of combined transcatheter arterial chemoembolization and threedimensional conformal radiotherapy for portal vein tumor thrombus in patients with unresectable hepatocellular carcinoma", Int J Radiat Oncol Biol Phys, 57, pp.113~119 (2003)
- Seong J, "Clinical results of 3-dimensional conformal radiotherapy combined with transarterial chemoembolization for hepatocellular carcinoma in the cirrhotic patients", HEPATOLOGY RESEARCH, 27, pp.30~35 (2003), BLACKWELL PUBLISHING
- 유찬란, "간문맥혈전을 동반한 거대 간세포암종 환자에서 간동맥항암 단독요법과 동시 방사선-간동맥항암 병합요법의 효과 비교", Clinical and Molecular Hepatology, 13(3), pp.378~386 (2007), 대한간학회
- Lawrence TS, "The use of 3-D dose volume analysis to predict radiation hepatitis", Int J Radiat Oncol Biol Phys, 23, pp.781~788 (1992)
- Blomgren H, "Radiosurgery for tumors in the body: clinical experience using a new method", J Radiosurgery, 1, pp.63~74 (1998)