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Could tofacitinib, the first oral small-molecule inhibitor proven for use in active rheumatoid arthritis (RA) patients with insufficient response to methotrexate, be the breakthrough drug for RA?

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참고문헌 (10)

  1. Harris ED Jr, "Rheumatoid arthritis: pathophysiology and implications for therapy", N Engl J Med, 322, pp.1277~1289 (1990)
  2. Changelian PS, "Prevention of organ allograft rejection by a specific Janus kinase 3inhibitor", Science, 302, pp.875~878 (2003)
  3. Tanaka Y, "Tofacitinib Study Investigators. Phase II study of tofacitinib (CP-690,550) combined with methotrexate in patients with rheumatoid arthritis and an inadequate response to methotrexate", Arthritis Care Res (Hoboken), 63, pp.1150~1158 (2011)
  4. Fleischmann R, "Phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690,550) or adalimumab monotherapy versus placebo in patients with active rheumatoid arthritis with an inadequate response to disease-modifying antirheumatic drugs", Arthritis Rheum, 64, pp.617~629 (2012)
  5. Kremer JM, "A phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690,550) versus placebo in combination with background methotrexate in patients with active rheumatoid arthritis and an inadequate response to methotrexate alone", Arthritis Rheum, 64, pp.970~981 (2012)
  6. van Vollenhoven RF, "Tofacitinib or adalimumab versus placebo in rheumatoid arthritis", N Engl J Med, 367, pp.508~519 (2012)
  7. Fleischmann R, "Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis", N Engl J Med, 367, pp.495~507 (2012)
  8. Traynor K, "FDA approves tofacitinib for rheumatoid arthritis", Am J Health Syst Pharm, 69, pp.2120~ (2012)
  9. 송관규, "Efficacy and safety of tofacitinib for active rheumatoid arthritis with an inadequate response to methotrexate or disease-modifying antirheumatic drugs: a meta-analysis of randomized controlled trials", The Korean Journal of Internal Medicine, 29(5), pp.656~663 (2014), 대한내과학회[DOI]
  10. Lee EB, "Tofacitinib versus methotrexate in rheumatoid arthritis", N Engl J Med, 370, pp.2377~2386 (2014)

관련 논문AI추천

Current concepts in the management of rheumatoid arthritisYoshiya Tanaka대한내과학회 · The Korean Journal of Internal Medicine2016 · 제31권 제2호Lessons From the Success and Failure of Targeted Drugs for Rheumatoid Arthritis: Perspectives for Effective Basic and Translational Research김민교, 이상일, 채용호대한면역학회 · Immune Network2022 · 제22권 제1호Recent Paradigm Shifts in the Diagnosis and Treatment of Rheumatoid Arthritis김현아, 정영옥대한내과학회 · The Korean Journal of Internal Medicine2012 · 제27권 제4호Comparative effectiveness of JAK inhibitors and biologic disease-modifying antirheumatic drugs in patients with rheumatoid arthritis김해림, 박민찬, 이연아, 이혜순, Bo Young Yoon, Eunwoo Nam, Hye Won Kim, Hyoun-Ah Kim, Hyoungyoung Kim, Hyun-Sook Kim, Jae Hoon Kim, Jeongim Choi, Jisoo Lee, Seung-Ki Kwok, Shin-Seok Lee, Soo-Kyung Cho, Sung Hae Chang, Sung-Hoon Park, Wan-Sik Uhm, Yeo-Jin Song, Yong-Gil Kim, Yoon-Kyoung Sung대한내과학회 · The Korean Journal of Internal Medicine2023 · 제38권 제4호CP-690550 Treatment Ameliorates Established Disease and Provides Long-Term Therapeutic Effects in an SKG Arthritis Model오근희, 이동섭, Hee-Yoon Lee, In Gyu Kim, Myung Won Seo, Young-il Hwang대한면역학회 · Immune Network2013 · 제13권 제6호Efficacy and safety of low-dose tacrolimus for active rheumatoid arthritis with an inadequate response to methotrexateMyeung-Soo Lee, Sang-Il Lee, Shin-Seok Lee, Sung-Il Kim, Wan-Hee Yoo, Won-Seok Lee대한내과학회 · The Korean Journal of Internal Medicine2016 · 제31권 제4호

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