A novel prognostic factor for hepatocellular carcinoma: protein disulfide isomerase
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Background/Aims: Protein disulfide isomerase (PDI) has been implicated in thesurvival and progression of some cancer cells, by compensating for endoplasmicreticulum stress by upregulating the protein-folding capacity. However, its prognosticrole in patients with hepatocellular carcinoma (HCC) has not been investigated. Methods: We collected HCC tissues from 83 HCC patients who underwent surgicalresection for an immunohistochemical study of PDI. Overall survival (OS)was measured from the date of surgical resection until the date of death from anycause. Radiological progression was evaluated using the modified Response EvaluationCriteria in Solid Tumors in an independent radiological assessment. Results: PDI expression was found to be increased in human HCC compared toadjacent nontumor tissues. Increased immunopositivity for PDI was associatedwith a high Edmondson-Steiner grade (p = 0.028). Univariate analysis of patientswho had undergone surgical resection for HCC showed that tumor PDI upregulationis a significant risk factor for poor OS (p = 0.016; hazard ratio [HR], 1.980) andtime to progression (TTP; p = 0.007; HR, 1.971). Multivariate analyses revealedthat high PDI expression was an independent predictor of a shorter TTP (p = 0.015;HR, 1.865) and poor OS (p = 0.012; HR, 2.069). Conclusions: Upregulated PDI expression is associated with aggressive clinicopathologicalfeatures of HCC; thus, PDI might serve as an independent prognosticfactor and a potential therapeutic target for HCC patients.
Abstract
Background/Aims: Protein disulfide isomerase (PDI) has been implicated in thesurvival and progression of some cancer cells, by compensating for endoplasmicreticulum stress by upregulating the protein-folding capacity. However, its prognosticrole in patients with hepatocellular carcinoma (HCC) has not been investigated. Methods: We collected HCC tissues from 83 HCC patients who underwent surgicalresection for an immunohistochemical study of PDI. Overall survival (OS)was measured from the date of surgical resection until the date of death from anycause. Radiological progression was evaluated using the modified Response EvaluationCriteria in Solid Tumors in an independent radiological assessment. Results: PDI expression was found to be increased in human HCC compared toadjacent nontumor tissues. Increased immunopositivity for PDI was associatedwith a high Edmondson-Steiner grade (p = 0.028). Univariate analysis of patientswho had undergone surgical resection for HCC showed that tumor PDI upregulationis a significant risk factor for poor OS (p = 0.016; hazard ratio [HR], 1.980) andtime to progression (TTP; p = 0.007; HR, 1.971). Multivariate analyses revealedthat high PDI expression was an independent predictor of a shorter TTP (p = 0.015;HR, 1.865) and poor OS (p = 0.012; HR, 2.069). Conclusions: Upregulated PDI expression is associated with aggressive clinicopathologicalfeatures of HCC; thus, PDI might serve as an independent prognosticfactor and a potential therapeutic target for HCC patients.
참고문헌 (24)
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