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Recent technological updates and clinical applications of induced pluripotent stem cells

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초록

Induced pluripotent stem cells (iPSCs) were first described in 2006 and havesince emerged as a promising cell source for clinical applications. The rapid progressionin iPSC technology is still ongoing and directed toward increasing theefficacy of iPSC production and reducing the immunogenic and tumorigenic potentialof these cells. Enormous efforts have been made to apply iPSC-based technologyin the clinic, for drug screening approaches and cell replacement therapy. Moreover, disease modeling using patient-specific iPSCs continues to expandour knowledge regarding the pathophysiology and prospective treatment of raredisorders. Furthermore, autologous stem cell therapy with patient-specific iPSCsshows great propensity for the minimization of immune reactions and the provisionof a limitless supply of cells for transplantation. In this review, we discussthe recent updates in iPSC technology and the use of iPSCs in disease modelingand regenerative medicine.

Abstract

Induced pluripotent stem cells (iPSCs) were first described in 2006 and havesince emerged as a promising cell source for clinical applications. The rapid progressionin iPSC technology is still ongoing and directed toward increasing theefficacy of iPSC production and reducing the immunogenic and tumorigenic potentialof these cells. Enormous efforts have been made to apply iPSC-based technologyin the clinic, for drug screening approaches and cell replacement therapy. Moreover, disease modeling using patient-specific iPSCs continues to expandour knowledge regarding the pathophysiology and prospective treatment of raredisorders. Furthermore, autologous stem cell therapy with patient-specific iPSCsshows great propensity for the minimization of immune reactions and the provisionof a limitless supply of cells for transplantation. In this review, we discussthe recent updates in iPSC technology and the use of iPSCs in disease modelingand regenerative medicine.

참고문헌 (77)

  1. Somorjai IM, "Stem cells: a view from the roots", Biotechnol J, 7, pp.704~722 (2012)
  2. Grskovic M, "Induced pluripotent stem cells: opportunities for disease modelling and drug discovery", Nat Rev Drug Discov, 10, pp.915~929 (2011)
  3. Schugar RC, "Small molecules in stem cell self-renewal and differentiation", Gene Ther, 15, pp.126~135 (2008)
  4. Murry CE, "Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development", Cell, 132, pp.661~680 (2008)
  5. Zaehres H, "Induction of pluripotency: from mouse to human", Cell, 131, pp.834~835 (2007)
  6. Takahashi K, "Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors", Cell, 126, pp.663~676 (2006)
  7. Maherali N, "Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution", Cell Stem Cell, 1, pp.55~70 (2007)
  8. Jaenisch R, "Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming", Cell, 132, pp.567~582 (2008)
  9. Takahashi K, "Induction of pluripotent stem cells from adult human fibroblasts by defined factors", Cell, 131, pp.861~872 (2007)
  10. Yu J, "Induced pluripotent stem cell lines derived from human somatic cells", Science, 318, pp.1917~1920 (2007)
  11. Chang CW, "Polycistronic lentiviral vector for “hit and run” reprogramming of adult skin fibroblasts to induced pluripotent stem cells", Stem Cells, 27, pp.1042~1049 (2009)
  12. Feng B, "Molecules that promote or enhance reprogramming of somatic cells to induced pluripotent stem cells", Cell Stem Cell, 4, pp.301~312 (2009)
  13. Heinrich EM, "MicroRNAs and stem cells:control of pluripotency, reprogramming, and lineage commitment", Circ Res, 110, pp.1014~1022 (2012)
  14. Kretsovali A, "Histone deacetylase inhibitors in cell pluripotency, differentiation, and reprogramming", Stem Cells Int, 2012, pp.184154~ (2012)
  15. Bayart E, "Technological overview of iPS induction from human adult somatic cells", Curr Gene Ther, 13, pp.73~92 (2013)
  16. Gonzalez F, "Methods for making induced pluripotent stem cells: reprogramming a la carte", Nat Rev Genet, 12, pp.231~242 (2011)
  17. Stadtfeld M, "Induced pluripotent stem cells generated without viral integration", Science, 322, pp.945~949 (2008)
  18. Stadtfeld M, "Induced pluripotency:history, mechanisms, and applications", Genes Dev, 24, pp.2239~2263 (2010)
  19. Zhou H, "Generation of induced pluripotent stem cells using recombinant proteins", Cell Stem Cell, 4, pp.381~384 (2009)
  20. Jia F, "A nonviral minicircle vector for deriving human iPS cells", Nat Methods, 7, pp.197~199 (2010)
  21. Warren L, "Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA", Cell Stem Cell, 7, pp.618~630 (2010)
  22. Hayden EC, "California ponders cell-banking venture", Nature, 472, pp.403~ (2011)
  23. Fusaki N, "Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome", Proc Jpn Acad Ser B Phys Biol Sci, 85, pp.348~362 (2009)
  24. Dowey SN, "Generation of integration-free human induced pluripotent stem cells from postnatal blood mononuclear cells by plasmid vector expression", Nat Protoc, 7, pp.2013~2021 (2012)
  25. Ban H, "Efficient generation of transgene-free human induced pluripotent stem cells (iPSCs) by temperature-sensitive Sendai virus vectors", Proc Natl Acad Sci U S A, 108, pp.14234~14239 (2011)
  26. Okita K, "Generation of mouse induced pluripotent stem cells without viral vectors", Science, 322, pp.949~953 (2008)
  27. Gonzalez F, "Generation of mouse-induced pluripotent stem cells by transient expression of a single nonviral polycistronic vector", Proc Natl Acad Sci U S A, 106, pp.8918~8922 (2009)
  28. Diecke S, "Cardiac Tissue Engineering: Methods and Protocols. Vol. 1181" (2014), Humana Press
  29. Yu J, "Human induced pluripotent stem cells free of vector and transgene sequences", Science, 324, pp.797~801 (2009)
  30. Lu J, "The extragenic spacer length between the 5’ and 3’ ends of the transgene expression cassette affects transgene silencing from plasmid-based vectors", Mol Ther, 20, pp.2111~2119 (2012)
  31. Chen ZY, "Minicircle DNA vectors devoid of bacterial DNA result in persistent and high-level transgene expression in vivo", Mol Ther, 8, pp.495~500 (2003)
  32. Narsinh KH, "Generation of adult human induced pluripotent stem cells using nonviral minicircle DNA vectors", Nat Protoc, 6, pp.78~88 (2011)
  33. Lu J, "A mini-intronic plasmid (MIP):a novel robust transgene expression vector in vivo and in vitro", Mol Ther, 21, pp.954~963 (2013)
  34. Hung SC, "Maintenance of Epstein-Barr virus (EBV) oriP-based episomes requires EBV-encoded nuclear antigen-1 chromosome-binding domains, which can be replaced by high-mobility group-I or histone H1", Proc Natl Acad Sci U S A, 98, pp.1865~1870 (2001)
  35. Okita K, "An efficient nonviral method to generate integration-free human-induced pluripotent stem cells from cord blood and peripheral blood cells", Stem Cells, 31, pp.458~466 (2013)
  36. Mandal PK, "Reprogramming human fibroblasts to pluripotency using modified mRNA", Nat Protoc, 8, pp.568~582 (2013)
  37. Colamonici OR, "Vaccinia virus B18R gene encodes a type I interferon-binding protein that blocks interferon alpha transmembrane signaling", J Biol Chem, 270, pp.15974~15978 (1995)
  38. Amit M, "No evidence for infection of human embryonic stem cells by feeder cell-derived murine leukemia viruses", Stem Cells, 23, pp.761~771 (2005)
  39. Warren L, "Feeder-free derivation of human induced pluripotent stem cells with messenger RNA", Sci Rep, 2, pp.657~ (2012)
  40. Yoshioka N, "Efficient generation of human iPSCs by a synthetic self-replicative RNA", Cell Stem Cell, 13, pp.246~254 (2013)
  41. Kim D, "Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins", Cell Stem Cell, 4, pp.472~476 (2009)
  42. Lee J, "Activation of innate immunity is required for efficient nuclear reprogramming", Cell, 151, pp.547~558 (2012)
  43. Hou P, "Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds", Science, 341, pp.651~654 (2013)
  44. Zwaka TP, "Homologous recombination in human embryonic stem cells", Nat Biotechnol, 21, pp.319~321 (2003)
  45. Hockemeyer D, "Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases", Nat Biotechnol, 27, pp.851~857 (2009)
  46. Ding Q, "A TALEN genome-editing system for generating human stem cell-based disease models", Cell Stem Cell, 12, pp.238~251 (2013)
  47. Horii T, "Genome engineering of mammalian haploid embryonic stem cells using the Cas9", RNA system, 2013, pp.1, e230~
  48. Cheng LT, "Genome editing in induced pluripotent stem cells", Genes Cells, 17, pp.431~438 (2012)
  49. Kim H, "A guide to genome engineering with programmable nucleases", Nat Rev Genet, 15, pp.321~334 (2014)
  50. Robinton DA, "The promise of induced pluripotent stem cells in research and therapy", Nature, 481, pp.295~305 (2012)
  51. Tiscornia G, "Diseases in a dish: modeling human genetic disorders using induced pluripotent cells", Nat Med, 17, pp.1570~1576 (2011)
  52. Urbach A, "Modeling for Lesch-Nyhan disease by gene targeting in human embryonic stem cells", Stem Cells, 22, pp.635~641 (2004)
  53. Park IH, "Disease-specific induced pluripotent stem cells", Cell, 134, pp.877~886 (2008)
  54. Dimos JT, "Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons", Science, 321, pp.1218~1221 (2008)
  55. Urbach A, "Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells", Cell Stem Cell, 6, pp.407~411 (2010)
  56. Carvajal-Vergara X, "Patient-specif ic induced pluripotent stem-cell-derived models of LEOPARD syndrome", Nature, 465, pp.808~812 (2010)
  57. Yazawa M, "Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome", Nature, 471, pp.230~234 (2011)
  58. Itzhaki I, "Modelling the long QT syndrome with induced pluripotent stem cells", Nature, 471, pp.225~229 (2011)
  59. Brennand KJ, "Modelling schizophrenia using human induced pluripotent stem cells", Nature, 473, pp.221~225 (2011)
  60. Jang J, "Induced pluripotent stem cell models from X-linked adrenoleukodystrophy patients", Ann Neurol, 70, pp.402~409 (2011)
  61. Perel P, "Comparison of treatment effects between animal experiments and clinical trials: systematic review", BMJ, 334, pp.197~ (2007)
  62. Frey-Vasconcells J, "Translation of stem cell research: points to consider in designing preclinical animal studies", Stem Cells Transl Med, 1, pp.353~358 (2012)
  63. Kramer AS, "Systematic review of induced pluripotent stem cell technology as a potential clinical therapy for spinal cord injury", Cell Transplant, 22, pp.571~617 (2013)
  64. Kola I, "Can the pharmaceutical industry reduce attrition rates?", Nat Rev Drug Discov, 3, pp.711~715 (2004)
  65. Irion S, "Directed differentiation of pluripotent stem cells: from developmental biology to therapeutic applications", Cold Spring Harb Symp Quant Biol, 73, pp.101~110 (2008)
  66. Zhu H, "Investigating monogenic and complex diseases with pluripotent stem cells", Nat Rev Genet, 12, pp.266~275 (2011)
  67. Saha K, "Technical challenges in using human induced pluripotent stem cells to model disease", Cell Stem Cell, 5, pp.584~595 (2009)
  68. Miller JD, "Human iPSC-based modeling of late-onset disease via progerin-induced aging", Cell Stem Cell, 13, pp.691~705 (2013)
  69. Wernig M, "Neurons derived from reprogrammed f ibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson’s disease", Proc Natl Acad Sci U S A, 105, pp.5856~5861 (2008)
  70. Hanna J, "Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin", Science, 318, pp.1920~1923 (2007)
  71. Lui KO, "Embryonic stem cells: overcoming the immunological barriers to cell replacement therapy", Curr Stem Cell Res Ther, 4, pp.70~80 (2009)
  72. Takebe T, "Vascularized and functional human liver from an iPSC-derived organ bud transplant", Nature, 499, pp.481~484 (2013)
  73. Kamao H, "Characterization of human induced pluripotent stem cell-derived retinal pigment epithelium cell sheets aiming for clinical application", Stem Cell Reports, 2, pp.205~218 (2014)
  74. Zimmermann A, "Haplotype-based banking of human pluripotent stem cells for transplantation: potential and limitations", Stem Cells Dev, 21, pp.2364~2373 (2012)
  75. Taylor CJ, "Generating an iPSC bank for HLA-matched tissue transplantation based on known donor and recipient HLA types", Cell Stem Cell, 11, pp.147~152 (2012)
  76. Lin G, "HLA-matching potential of an established human embryonic stem cell bank in China", Cell Stem Cell, 5, pp.461~465 (2009)
  77. Taylor CJ, "Immunological considerations for embryonic and induced pluripotent stem cell banking", Philos Trans R Soc Lond B Biol Sci, 366, pp.2312~2322 (2011)

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