Relationship between duration of hospitalacquired acute kidney injury and mortality: a prospective observational study
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Background/Aims: New definitions of acute kidney injury (AKI) have recentlyemerged. Some studies have suggested that duration of AKI is an additional predictiveparameter for mortality. Here, we evaluated whether AKI duration waspredictive of long-term mortality in patients with hospital-acquired acute kidneyinjury (HAAKI). Methods: We prospectively enrolled patients who developed HAAKI at an urbanuniversity hospital, from September 2007 to August 2008 and followed them untilDecember 2011. Patients were divided into two groups by duration of the AKI (1to 5 days vs. ≥ 6 days), and long-term mortality was compared. Results: HAAKI developed in 1.2% of patients during the enrollment period. The median follow-up period was 240 days (interquartile range, 53 to 1,428). In42.3% of patients (n = 52), the AKI lasted 1 to 5 days, while it lasted ≥ 6 days in 57.7%(n = 71). Survival analysis showed that a longer duration of AKI increased the riskof death. Long-term survival was significantly different in the two groups. Conclusions: The duration of AKI influenced mortality rates in hospitalized patients. Thus, AKI duration is a parameter affecting mortality in HAAKI.
Abstract
Background/Aims: New definitions of acute kidney injury (AKI) have recentlyemerged. Some studies have suggested that duration of AKI is an additional predictiveparameter for mortality. Here, we evaluated whether AKI duration waspredictive of long-term mortality in patients with hospital-acquired acute kidneyinjury (HAAKI). Methods: We prospectively enrolled patients who developed HAAKI at an urbanuniversity hospital, from September 2007 to August 2008 and followed them untilDecember 2011. Patients were divided into two groups by duration of the AKI (1to 5 days vs. ≥ 6 days), and long-term mortality was compared. Results: HAAKI developed in 1.2% of patients during the enrollment period. The median follow-up period was 240 days (interquartile range, 53 to 1,428). In42.3% of patients (n = 52), the AKI lasted 1 to 5 days, while it lasted ≥ 6 days in 57.7%(n = 71). Survival analysis showed that a longer duration of AKI increased the riskof death. Long-term survival was significantly different in the two groups. Conclusions: The duration of AKI influenced mortality rates in hospitalized patients. Thus, AKI duration is a parameter affecting mortality in HAAKI.
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