Long-term survival after concurrent chemoradiation therapy for esophageal cancer with tracheal invasion
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Esophageal cancer is a highly lethal malignancy with poor survival outcome, and usually presents in advanced stage due to its anatomical characteristics. Treatment of esophageal cancer with airway invasion continues to present difficult management decisions. In these patients, surgery is not considered for the treatment modality because operative complications are considerable and the prognosis is poor, even if radical esophageal dissection may be achieved by combined excision of the trachea. Although long-term survival has been reported in a minority of patients with T4 esophageal cancer after combined chemoradiation therapy, such cases have also been associated with worsening or development of new fistulas as well as treatment-related deaths in a significant proportion of patients [1]. Here we report on a case of a patient with advanced esophageal squamous cell carcinoma with tracheal invasion treated by concurrent chemoradiotherapy, resulting in sustained complete regression.
Abstract
Esophageal cancer is a highly lethal malignancy with poor survival outcome, and usually presents in advanced stage due to its anatomical characteristics. Treatment of esophageal cancer with airway invasion continues to present difficult management decisions. In these patients, surgery is not considered for the treatment modality because operative complications are considerable and the prognosis is poor, even if radical esophageal dissection may be achieved by combined excision of the trachea. Although long-term survival has been reported in a minority of patients with T4 esophageal cancer after combined chemoradiation therapy, such cases have also been associated with worsening or development of new fistulas as well as treatment-related deaths in a significant proportion of patients [1]. Here we report on a case of a patient with advanced esophageal squamous cell carcinoma with tracheal invasion treated by concurrent chemoradiotherapy, resulting in sustained complete regression.
참고문헌 (5)
- Nishimura Y, "Prospective trial of concurrent chemoradiotherapy with protracted infusion of 5-fluorouracil and cisplatin for T4 esophageal cancer with or without fistula", Int J Radiat Oncol Biol Phys, 53, pp.134~139 (2002)
- Rice TW, "Cancer of the esophagus and esophagogastric junction: data-driven staging for the seventh edition of the American Joint Committee on Cancer", International Union Against Cancer Cancer Staging Manuals, 2010, pp.116, 3763~3773
- Minsky BD, "Final report of Intergroup Trial 0122 (ECOG PE-289, RTOG 90-12):phase II trial of neoadjuvant chemotherapy plus concurrent chemotherapy and high-dose radiation for squamous cell carcinoma of the esophagus", Int J Radiat Oncol Biol Phys, 43, pp.517~523 (1999)
- Stahl M, "Chemoradiation with and without surgery in patients with locally advanced squamous cell carcinoma of the esophagus", J Clin Oncol, 23, pp.2310~2317 (2005)
- Kinoshita Y, "Esophageal carcinoma with tracheal stenosis due to tumor invasion and long survival after chemoradiotherapy", Dis Esophagus, 16, pp.261~264 (2003)