Clinical Features and Associated Abnormalities in Children and Adolescents With Corpus Callosal Anomalies
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Callosal anomalies are frequently associated with other central nervous system (CNS) and/or somatic anomalies. We retrospectively analyzed the clinical features of corpus callosal agenesis/hypoplasia accompanying other CNS and/or somatic anomalies. We reviewed the imaging and clinical information of patients who underwent brain magnetic resonance imaging in our hospital, between 2005 and 2012. Callosal anomalies were isolated in 13 patients, accompanied by other CNS anomalies in 10 patients, associated with only non-CNS somatic anomalies in four patients, and with both CNS and non-CNS abnormalities in four patients. Out of 31 patients, four developed normally, without impairments in motor or cognitive functions. Five of nine patients with cerebral palsy were accompanied by other CNS and/or somatic anomalies, and showed worse Gross Motor Function Classification System scores, compared with the other four patients with isolated callosal anomaly. In addition, patients with other CNS anomalies also had a higher seizure risk.
Abstract
Callosal anomalies are frequently associated with other central nervous system (CNS) and/or somatic anomalies. We retrospectively analyzed the clinical features of corpus callosal agenesis/hypoplasia accompanying other CNS and/or somatic anomalies. We reviewed the imaging and clinical information of patients who underwent brain magnetic resonance imaging in our hospital, between 2005 and 2012. Callosal anomalies were isolated in 13 patients, accompanied by other CNS anomalies in 10 patients, associated with only non-CNS somatic anomalies in four patients, and with both CNS and non-CNS abnormalities in four patients. Out of 31 patients, four developed normally, without impairments in motor or cognitive functions. Five of nine patients with cerebral palsy were accompanied by other CNS and/or somatic anomalies, and showed worse Gross Motor Function Classification System scores, compared with the other four patients with isolated callosal anomaly. In addition, patients with other CNS anomalies also had a higher seizure risk.
참고문헌 (10)
- Szabo N, "Corpus callosum anomalies: birth prevalence and clinical spectrum in Hungary", Pediatr Neurol, 44, pp.420~426 (2011)
- Glass HC, "Agenesis of the corpus callosum in California 1983-2003: a population-based study", Am J Med Genet A, 146A, pp.2495~2500 (2008)
- Boland E, "Mapping of deletion and translocation breakpoints in 1q44 implicates the serine", threonine kinase AKT3 in postnatal microcephaly and agenesis of the corpus callosum, 2007, pp.81, 292~303
- Marszał E, "Agenesis of corpus callosum:clinical description and etiology", J Child Neurol, 15, pp.401~405 (2000)
- 김광준, "Prenatally diagnosed agenesis of corpus callosum", Obstetrics & Gynecology Science, 52(12), pp.1239~1244 (2009), 대한산부인과학회
- Paul LK, "Agenesis of the corpus callosum:genetic, developmental and functional aspects of connectivity", Nat Rev Neurosci, 8, pp.287~299 (2007)
- Mangione R, "Neurodevelopmental outcome following prenatal diagnosis of an isolated anomaly of the corpus callosum", Ultrasound Obstet Gynecol, 37, pp.290~295 (2011)
- Tang PH, "Agenesis of the corpus callosum: an MR imaging analysis of associated abnormalities in the fetus", AJNR Am J Neuroradiol, 30, pp.257~263 (2009)
- Francesco P, "Prenatal diagnosis of agenesis of corpus callosum: what is the neurodevelopmental outcome?", Pediatr Int, 48, pp.298~304 (2006)
- Byrd SE, "The clinical and radiological evaluation of absence of the corpus callosum", Eur J Radiol, 10, pp.65~73 (1990)