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Response to comment on “Hypogonadotrophic hypogonadism due to a mutation in the luteinizing hormone β-subunit gene”

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Although we used low-dose testosterone to induce pubertal changes in our present case (a convenient procedure complying with the wishes of the patient), we agree that the use of hCG or recombinant LH to induce puberty maximizes the testicular response and future potential fertility in patients with isolated LH deficiency.

Abstract

Although we used low-dose testosterone to induce pubertal changes in our present case (a convenient procedure complying with the wishes of the patient), we agree that the use of hCG or recombinant LH to induce puberty maximizes the testicular response and future potential fertility in patients with isolated LH deficiency.

참고문헌 (3)

  1. Jae Won Song, "Hypogonadotrophic hypogonadism due to a mutation in the luteinizing hormone β-subunit gene", The Korean Journal of Internal Medicine (2017), Korean Association of Internal Medicine[DOI]
  2. Potorac I, "A vital region for human glycoprotein hormone trafficking revealed by an LHB mutation", J Endocrinol, 231, pp.197~207 (2016)
  3. Rohayem J, "Testicular growth and spermatogenesis:new goals for pubertal hormone replacement in boys with hypogonadotropic hypogonadism? A multicentre prospective study of hCG", rFSH treatment outcomes during adolescence, 2017, pp.86, 75~87

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