Epidemiological trend of pulmonary thromboembolism at a tertiary hospital in Korea
2
조회
0
다운로드
5
인용
0
참고문헌
키워드
초록
Background/Aims: Despite increasing interest in pulmonary thromboembolism (PTE), data on recent trends in PTE incidence are limited. This study evaluated the recent incidence rate of PTE. Methods: We performed a retrospective chart review of patients with PTE admitted to Chung-Ang University Hospital during the 10-year period from 2006 to 2015. Age-standardized incidence and mortality rates were calculated by the direct method per 100,000 populations. To analyze the trend of risk factor, we also calculated the proportions of cancer, major operation, and recent major fracture over that time. Results: Total crude incidence rate of PTE per 100,000 was 229.36 and the agesex adjusted standardized incidence rate was 151.28 (95% confidence interval [CI], 127.88 to 177.10). The incidence rate have been significantly increased 1.083 times annually from 2006 (105.96 per 100,000) to 2015 (320.02 per 100,000) (95% CI, 1.049 to 1.118; p < 0.001). These incidences also increased annually in age group of 35 to 54, 55 to 74, and ≥ 75 years, and in both males (odds ratio [OR], 1.071; 95% CI, 1.019 to 1.127; p = 0.007) and females (OR, 1.091; 95% CI, 1.047 to 1.136; p < 0.001). Cancer accounted for most of the increase from 20.0% at 2006 to 2007 to 42.8% at 2014 to 2015 (OR, 1.154; 95% CI, 1.074 to 1.240; p < 0.001), while the proportions of recent fracture and major operation remained constant. Conclusions: The incidence of pulmonary embolism has gradually increased over the 10 years. The increase of PTE incidence was mainly due to increased proportion of cancer patients.
Abstract
Background/Aims: Despite increasing interest in pulmonary thromboembolism (PTE), data on recent trends in PTE incidence are limited. This study evaluated the recent incidence rate of PTE. Methods: We performed a retrospective chart review of patients with PTE admitted to Chung-Ang University Hospital during the 10-year period from 2006 to 2015. Age-standardized incidence and mortality rates were calculated by the direct method per 100,000 populations. To analyze the trend of risk factor, we also calculated the proportions of cancer, major operation, and recent major fracture over that time. Results: Total crude incidence rate of PTE per 100,000 was 229.36 and the agesex adjusted standardized incidence rate was 151.28 (95% confidence interval [CI], 127.88 to 177.10). The incidence rate have been significantly increased 1.083 times annually from 2006 (105.96 per 100,000) to 2015 (320.02 per 100,000) (95% CI, 1.049 to 1.118; p < 0.001). These incidences also increased annually in age group of 35 to 54, 55 to 74, and ≥ 75 years, and in both males (odds ratio [OR], 1.071; 95% CI, 1.019 to 1.127; p = 0.007) and females (OR, 1.091; 95% CI, 1.047 to 1.136; p < 0.001). Cancer accounted for most of the increase from 20.0% at 2006 to 2007 to 42.8% at 2014 to 2015 (OR, 1.154; 95% CI, 1.074 to 1.240; p < 0.001), while the proportions of recent fracture and major operation remained constant. Conclusions: The incidence of pulmonary embolism has gradually increased over the 10 years. The increase of PTE incidence was mainly due to increased proportion of cancer patients.
참고문헌 (24)
- Stein PD, "Trends in the incidence of pulmonary embolism and deep venous thrombosis in hospitalized patients", Am J Cardiol, 95, pp.1525~1526 (2005)
- Oger E., "Groupe d’Etude de la Thrombose de Bretagne Occidentale", Thromb Haemost, 83, pp.657~660 (2000)
- Ho WK, "The incidence of venous thromboembolism: a prospective, community-based study in Perth", Med J Aust, 189, pp.144~147 (2008)
- Mahan CE, "Venous thromboembolism: annualized United States models for total, hospital-acquired and preventable costs utilizing long-term attack rates", Thromb Haemost, 108, pp.291~302 (2012)
- Goldhaber SZ, "Pulmonary embolism and deep vein thrombosis", Lancet, 379, pp.1835~1846 (2012)
- Agnelli G, "Acute pulmonary embolism", N Engl J Med, 363, pp.266~274 (2010)
- Kroger K, "Prevalence and economic burden of pulmonary embolism in Germany", Vasc Med, 17, pp.303~309 (2012)
- Anderson FA Jr, "A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism: the Worcester DVT Study", Arch Intern Med, 151, pp.933~938 (1991)
- Silverstein MD, "Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study", Arch Intern Med, 158, pp.585~593 (1998)
- Jang MJ, "Incidence of venous thromboembolism in Korea: from the Health Insurance Review and Assessment Service database", J Thromb Haemost, 9, pp.85~91 (2011)
- Choi WI, "Estimated incidence of acute pulmonary embolism in a Korean hospital", Clin Appl Thromb Hemost, 17, pp.297~301 (2011)
- Kim DS., "Introduction: health of the health care system in Korea", Soc Work Public Health, 25, pp.127~141 (2010)
- Stein PD, "Incidence of acute pulmonary embolism in a general hospital: relation to age, sex, and race", Chest, 116, pp.909~913 (1999)
- Sakuma M, "Venous Thromboembolism", pp.3~12 (2005), Springer
- DeMonaco NA, "Pulmonary embolism incidence is increasing with use of spiral computed tomography", Am J Med, 121, pp.611~617 (2008)
- Wiener RS, "Time trends in pulmonary embolism in the United States: evidence of overdiagnosis", Arch Intern Med, 171, pp.831~837 (2011)
- Schissler AJ, "National trends in emergency room diagnosis of pulmonary embolism, 2001-2010: a cross-sectional study", Respir Res, 16, pp.44~ (2015)
- Shen VS, "Fatal pulmonary embolism in cancer patients: is heparin prophylaxis justified?", South Med J, 73, pp.841~843 (1980)
- Jemal A, "Global patterns of cancer incidence and mortality rates and trends", Cancer Epidemiol Biomarkers Prev, 19, pp.1893~1907 (2010)
- 정규원, "Cancer Statistics in Korea: Incidence, Mortality, Survival and Prevalence in 2010", Cancer Research and Treatment, 45(1), pp.1~14 (2013), 대한암학회[DOI]
- Abdel-Razeq HN, "Incidental pulmonary embolism in cancer patients: clinical characteristics and outcome: a comprehensive cancer center experience", Vasc Health Risk Manag, 7, pp.153~158 (2011)
- Lyman GH, "American Society of Clinical Oncology guideline: recommendations for venous thromboembolism prophylaxis and treatment in patients with cancer", J Clin Oncol, 25, pp.5490~5505 (2007)
- Hardwick ME, "Advances in DVT prophylaxis and management in major orthopaedic surgery", Surg Technol Int, 12, pp.265~268 (2004)
- Keller K, "The risk factor age in normotensive patients with pulmonary embolism: effectiveness of age in predicting submassive pulmonary embolism, cardiac injury, right ventricular dysfunction and elevated systolic pulmonary artery pressure in normotensive pulmonary embolism patients", Exp Gerontol, 69, pp.116~121 (2015)