Long-term study of the association of adipokines and glucose variability with diabetic complications
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Background/Aims: Recent studies have suggested an important role of adipokines in the development of insulin resistance and diabetes mellitus. The clinical relevance of adipokines on long-term outcomes in patients with diabetes and chronic kidney disease is uncertain. The purpose of this study was to identify a predictable factor in patients with long-term diabetic complications. Methods: A total of 161 diabetic individuals were followed-up from 2002 to 2013. Circulating plasma levels of adiponectin, glypican-4, irisin, visfatin, and visit- to-visit glucose variability were measured in diabetic patients. Associations among adipokines and variable metabolic parameters and microvascular, and macrovascular complications were evaluated. Results: Plasma adiponectin and glypican-4 levels were significantly increased in patients with renal insufficiency. These adipokines were negatively associated with estimated glomerular filtration rate and positively associated with urinary albumin excretion. The relative risk of renal progression to dialysis increased independently with increasing level of adiponectin. Glypican-4 and visfatin were not predictive of any microvascular or macrovascular complications. Glucose variability increased the risk of diabetic nephropathy and cerebrovascular complications. Conclusions: Adiponectin and glypican-4 were associated with renal function and might be able to predict renal progression. Glucose variability was a predictable factor for diabetic nephropathy and cerebrovascular complications.
Abstract
Background/Aims: Recent studies have suggested an important role of adipokines in the development of insulin resistance and diabetes mellitus. The clinical relevance of adipokines on long-term outcomes in patients with diabetes and chronic kidney disease is uncertain. The purpose of this study was to identify a predictable factor in patients with long-term diabetic complications. Methods: A total of 161 diabetic individuals were followed-up from 2002 to 2013. Circulating plasma levels of adiponectin, glypican-4, irisin, visfatin, and visit- to-visit glucose variability were measured in diabetic patients. Associations among adipokines and variable metabolic parameters and microvascular, and macrovascular complications were evaluated. Results: Plasma adiponectin and glypican-4 levels were significantly increased in patients with renal insufficiency. These adipokines were negatively associated with estimated glomerular filtration rate and positively associated with urinary albumin excretion. The relative risk of renal progression to dialysis increased independently with increasing level of adiponectin. Glypican-4 and visfatin were not predictive of any microvascular or macrovascular complications. Glucose variability increased the risk of diabetic nephropathy and cerebrovascular complications. Conclusions: Adiponectin and glypican-4 were associated with renal function and might be able to predict renal progression. Glucose variability was a predictable factor for diabetic nephropathy and cerebrovascular complications.
참고문헌 (38)
- Pradhan AD, "C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus", JAMA, 286, pp.327~334 (2001)[DOI]
- Devaraj S, "Increased monocytic activity and biomarkers of inflammation in patients with type 1 diabetes", Diabetes, 55, pp.774~779 (2006)[DOI]
- Lafontan M, "Adipose tissue and adipocyte dysregulation", Diabetes Metab, 40, pp.16~28 (2014)[DOI]
- Romacho T, "Adipose tissue and its role in organ crosstalk", Acta Physiol (Oxf ), 210, pp.733~753 (2014)[DOI]
- Mills KT, "Circulating adipocytokines and chronic kidney disease", PLoS One, 8, pp.e76902~ (2013)[DOI]
- Adamczak M, "Adiponectin in patients with chronic kidney disease", Semin Dial, 22, pp.391~395 (2009)[DOI]
- Briffa JF, "Adipokines as a link between obesity and chronic kidney disease", Am J Physiol Renal Physiol, 305, pp.F1629~F1636 (2013)[DOI]
- 민혜숙, "Effects of Toll-like receptor antagonist 4,5-dihydro-3-phenyl-5-isoxasole acetic acid on the progression of kidney disease in mice on a high-fat diet", Kidney Research and Clinical Practice, 33(1), pp.33~44 (2014), 대한신장학회
- Deng Y, "Adipokines as novel biomarkers and regulators of the metabolic syndrome", Ann N Y Acad Sci, 1212, pp.E1~E19 (2010)
- Jin JooCha, "Plasma leptinconcentrationsaregreaterintypeIIdiabeticpatientsand stimulatemonocytechemotacticpeptide-1synthesisviathemitogen-activatedproteinkinase", extracellularsignal-regulatedkinasepathway, 2012, pp.31(3), 177~185[DOI]
- Alberti KG, "Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation", Diabet Med, 15, pp.539~553 (1998)[DOI]
- Chamberlain JJ, "Diagnosis and management of diabetes: synopsis of the 2016 American Diabetes Association standards of medical care in diabetes", Ann Intern Med, 164, pp.542~552 (2016)[DOI]
- Tuttle KR, "Diabetic kidney disease: a report from an ADA Consensus Conference", Am J Kidney Dis, 64, pp.510~533 (2014)[DOI]
- Guo X, "Adiponectin retards the progression of diabetic nephropathy in db", db mice by counteracting angiotensin II, 2014, pp.2, e00230~
- Jorsal A, "Serum adiponectin predicts all-cause mortality and end stage renal disease in patients with type I diabetes and diabetic nephropathy", Kidney Int, 74, pp.649~654 (2008)[DOI]
- Menon V, "Adiponectin and mortality in patients with chronic kidney disease", J Am Soc Nephrol, 17, pp.2599~2606 (2006)[DOI]
- Looker HC, "Adiponectin concentrations are influenced by renal function and diabetes duration in Pima Indians with type 2 diabetes", J Clin Endocrinol Metab, 89, pp.4010~4017 (2004)[DOI]
- Martinez Cantarin MP, "Adiponectin receptor and adiponectin signaling in human tissue among patients with end-stage renal disease", Nephrol Dial Transplant, 29, pp.2268~2277 (2014)[DOI]
- Guebre-Egziabher F, "Adiponectin in chronic kidney disease is related more to metabolic disturbances than to decline in renal function", Nephrol Dial Transplant, 20, pp.129~134 (2005)[DOI]
- Martinez Cantarin MP, "The adipose tissue production of adiponectin is increased in end-stage renal disease", Kidney Int, 83, pp.487~494 (2013)[DOI]
- Herder C, "Differential association between biomarkers of subclinical inflammation and painful polyneuropathy: results from the KORA F4 study", Diabetes Care, 38, pp.91~96 (2015)[DOI]
- Ussar S, "Glypican-4 enhances insulin signaling via interaction with the insulin receptor and serves as a novel adipokine", Diabetes, 61, pp.2289~2298 (2012)[DOI]
- Yoo HJ, "Association of glypican- 4 with body fat distribution, insulin resistance, and nonalcoholic fatty liver disease", J Clin Endocrinol Metab, 98, pp.2897~2901 (2013)[DOI]
- Watanabe K, "K-glypican: a novel GPI-anchored heparin sulfate proteoglycan that is highly expressed in developing brain and kidney", J Cell Biol, 130, pp.1207~1218 (1995)[DOI]
- Strate I, "Glypican4 promotes cardiac specification and differentiation by attenuating canonical Wnt and Bmp signaling", Development, 142, pp.1767~1776 (2015)[DOI]
- Chang GY, "Tracing the footsteps of glomerular insulin signaling in diabetic kidney disease", Kidney Int, 79, pp.802~804 (2011)[DOI]
- Hirakawa Y, "Impact of visit- to-visit glycemic variability on the risks of macrovascular and microvascular events and all-cause mortality in type 2 diabetes: the ADVANCE trial", Diabetes Care, 37, pp.2359~2365 (2014)[DOI]
- Muggeo M, "Fasting plasma glucose variability predicts 10-year survival of type 2 diabetic patients: the Verona Diabetes Study", Diabetes Care, 23, pp.45~50 (2000)[DOI]
- Ceriello A, "Oscillating glucose is more deleterious to endothelial function and oxidative stress than mean glucose in normal and type 2 diabetic patients", Diabetes, 57, pp.1349~1354 (2008)[DOI]
- Wu J, "Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human", Cell, 150, pp.366~376 (2012)[DOI]
- Roca-Rivada A, "FNDC5", irisin is not only a myokine but also an adipokine, 2013, pp.8, e60563~
- Liu JJ, "Lower circulating irisin is associated with type 2 diabetes mellitus", J Diabetes Complications, 27, pp.365~369 (2013)[DOI]
- Liu JJ, "Relationship between circulating irisin, renal function and body composition in type 2 diabetes", J Diabetes Complications, 28, pp.208~213 (2014)[DOI]
- Li DJ, "Metformin promotes irisin release from murine skeletal muscle independently of AMP-activated protein kinase activation", Acta Physiol (Oxf ), 213, pp.711~721 (2015)[DOI]
- Moschen AR, "Visfatin, an adipocytokine with proinflammatory and immunomodulating properties", J Immunol, 178, pp.1748~1758 (2007)[DOI]
- 강영선, "The Role of Visfatin in Diabetic Nephropathy", 전남의대학술지, 47(3), pp.139~143 (2011), 의과학연구소
- Vikram NK, "Anthropometry and body composition in northern Asian Indian patients with type 2 diabetes: receiver operating characteristics (ROC) curve analysis of body mass index with percentage body fat as standard", Diabetes Nutr Metab, 16, pp.32~40 (2003)
- Kollerits B, "Gender-specific association of adiponectin as a predictor of progression of chronic kidney disease: the Mild to Moderate Kidney Disease Study", Kidney Int, 71, pp.1279~1286 (2007)[DOI]
