Visual Evoked Potential in Children With Developmental Disorders: Correlation With Neurodevelopmental Outcomes
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Objective To investigate the neurodevelopmental outcomes in children with developmental disorder according to visual evoked potential (VEP) results. Methods We retrospectively analyzed children who visited our Department of Pediatric Rehabilitation Medicine with a chief complaint of developmental disability from January 2001 to July 2015. Of the 549 medical records reviewed, 322 children younger than 42 months who underwent both Bayley Scales of Infant and Toddler Development second edition (BSID-II) and VEP studies were enrolled. We compared the development of 182 children with normal VEP latency and 140 children with delayed VEP latency results using the BSID-II results. The Mann-Whitney U-test was used to analyze the differences between the two groups. Results There were no significant differences in baseline characteristics between the two groups. The delayed VEP latency group showed a significant delay in BSID-II index scores and developmental quotients compared with the normal VEP latency group. In addition, a comparative analysis of developmental quotients of mental and psychomotor domains according to age (younger than 12 months, 12–23 months, and 24–42 months) revealed significantly lower values in children with delayed VEP latency compared to children with normal VEP latency, younger than 12 months and from 12 to 23 months. Conclusion Children with delayed VEP latency showed more developmental delay than children with normal VEP latency. It is suggested that VEP can be easily applied to children with suspected developmental delay when physicians have concerns about visual impairment. Furthermore, it is proposed that VEP results could provide an insight into children’s development and serve as early indicators for consultation with an ophthalmologist for the existing problem.
Abstract
Objective To investigate the neurodevelopmental outcomes in children with developmental disorder according to visual evoked potential (VEP) results. Methods We retrospectively analyzed children who visited our Department of Pediatric Rehabilitation Medicine with a chief complaint of developmental disability from January 2001 to July 2015. Of the 549 medical records reviewed, 322 children younger than 42 months who underwent both Bayley Scales of Infant and Toddler Development second edition (BSID-II) and VEP studies were enrolled. We compared the development of 182 children with normal VEP latency and 140 children with delayed VEP latency results using the BSID-II results. The Mann-Whitney U-test was used to analyze the differences between the two groups. Results There were no significant differences in baseline characteristics between the two groups. The delayed VEP latency group showed a significant delay in BSID-II index scores and developmental quotients compared with the normal VEP latency group. In addition, a comparative analysis of developmental quotients of mental and psychomotor domains according to age (younger than 12 months, 12–23 months, and 24–42 months) revealed significantly lower values in children with delayed VEP latency compared to children with normal VEP latency, younger than 12 months and from 12 to 23 months. Conclusion Children with delayed VEP latency showed more developmental delay than children with normal VEP latency. It is suggested that VEP can be easily applied to children with suspected developmental delay when physicians have concerns about visual impairment. Furthermore, it is proposed that VEP results could provide an insight into children’s development and serve as early indicators for consultation with an ophthalmologist for the existing problem.
참고문헌 (18)
- Prechtl HF, "Role of vision on early motor development: lessons from the blind", Dev Med Child Neurol, 43, pp.198~201 (2001)[DOI]
- Levtzion-Korach O, "Early motor development of blind children", J Paediatr Child Health, 36, pp.226~229 (2000)[DOI]
- Vaizey MJ, "Neurological abnormalities in congenital amaurosis of Leber. Review of 30 cases", Arch Dis Child, 52, pp.399~402 (1977)[DOI]
- Cass HD, "Developmental setback in severe visual impairment", Arch Dis Child, 70, pp.192~196 (1994)[DOI]
- Odom JV, "ISCEV standard for clinical visual evoked potentials: (2016 update)", Doc Ophthalmol, 133, pp.1~9 (2016)
- Shepherd AJ, "Prognostic value of flash visual evoked potentials in preterm infants", Dev Med Child Neurol, 41, pp.9~15 (1999)[DOI]
- Vohr BR, "Are outcomes of extremely preterm infants improving? Impact of Bayley assessment on outcomes", J Pediatr, 161, pp.222~228 (2012)[DOI]
- Lowe JR, "Comparison of the Bayley II Mental Developmental Index and the Bayley III Cognitive Scale: are we measuring the same thing?", Acta Paediatr, 101, pp.e55~e58 (2012)[DOI]
- Moore T, "Relationship between test scores using the second and third editions of the Bayley Scales in extremely preterm children", J Pediatr, 160, pp.553~558 (2012)[DOI]
- Niccols A, "Stability of the Bayley mental scale of infant development with high risk infants", Br J Devel Disabil, 48, pp.3~13 (2002)[DOI]
- Drislane FW, "The clinical neurophysiology primer", pp.461~474 (2007), Humana Press
- Han SJ, "Comparison of visual evoked potentials between premature and full-term childrens", Acta Ophthalmol, 90(s249), pp.F067~ (2012)
- Kato T, "Visual evoked potential in the newborn: does it have predictive value?", Semin Fetal Neonatal Med, 11, pp.459~463 (2006)[DOI]
- Beverley DW, "Relationship of cranial ultrasonography, visual and auditory evoked responses with neurodevelopmental outcome", Dev Med Child Neurol, 32, pp.210~222 (1990)
- Ekert PG, "Visual evoked potentials for prediction of neurodevelopmental outcome in preterm infants", Biol Neonate, 71, pp.148~155 (1997)[DOI]
- Pike AA, "The role of cortical evoked responses in predicting neuromotor outcome in very preterm infants", Early Hum Dev, 57, pp.123~135 (2000)[DOI]
- Fulton AB, "Handbook of clinical neurophysiology: disorders of visual processing", pp.203~230 (2005), Elsevier
- Harding GF, "Principles and practice of clinical electrophysiology of vision", pp.585~588 (1991), Mosby