Clinical and economic analysis of the 2009 H1N1 influenza pandemic among pregnant Korean women
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Background/Aims: Unlike Western countries, the 2009 pandemic influenza infection among pregnant women was reported as mild in a previous interim study in South Korea. However, several mortalities were reported thereafter, suggesting that nationwide data were lacking. Methods: This case-control study covers the entire 2009 pandemic inf luenza period, from May 2009 to February 2010. The clinical and economic data of pregnant (case) and age-matched non-pregnant (control) women with influenza A (H1N1) pdm09 virus (H1N1pdm09) infection were retrospectively collected from nine hospitals in South Korea. Results: A total of 130 pregnant women with H1N1pdm09 infection were identified. The mean age of the pregnant women was 31.1 years (range, 19 to 41) and mean gestational age was 18.4 weeks (range, 3 to 40). Both case and control groups were similar in terms of age (p = 0.43) and comorbidities (p = 0.18). The overall rate of complications was comparable between the two groups (p = 0.648). However, mortality was reported only among the cases, so mean economic per capita burden is estimated to be higher for pregnant women compared to the control (4,821,992 Korean won [KRW] vs. 351,233 KRW, p = 0.31). Obstetric complications were observed in 12 cases, including preterm labor (n = 7), low birth-weight (n = 3), miscarriage (n = 1), stillbirth (n = 1), and cleft lip (n = 1). Conclusions: Although statistically insignificant, the detrimental impact of influenza A H1N1pdm09 on pregnancy can be serious in some complicated cases in South Korea. Thus, the strong recommendation of influenza vaccination should be maintained for pregnant women as a high priority.
Abstract
Background/Aims: Unlike Western countries, the 2009 pandemic influenza infection among pregnant women was reported as mild in a previous interim study in South Korea. However, several mortalities were reported thereafter, suggesting that nationwide data were lacking. Methods: This case-control study covers the entire 2009 pandemic inf luenza period, from May 2009 to February 2010. The clinical and economic data of pregnant (case) and age-matched non-pregnant (control) women with influenza A (H1N1) pdm09 virus (H1N1pdm09) infection were retrospectively collected from nine hospitals in South Korea. Results: A total of 130 pregnant women with H1N1pdm09 infection were identified. The mean age of the pregnant women was 31.1 years (range, 19 to 41) and mean gestational age was 18.4 weeks (range, 3 to 40). Both case and control groups were similar in terms of age (p = 0.43) and comorbidities (p = 0.18). The overall rate of complications was comparable between the two groups (p = 0.648). However, mortality was reported only among the cases, so mean economic per capita burden is estimated to be higher for pregnant women compared to the control (4,821,992 Korean won [KRW] vs. 351,233 KRW, p = 0.31). Obstetric complications were observed in 12 cases, including preterm labor (n = 7), low birth-weight (n = 3), miscarriage (n = 1), stillbirth (n = 1), and cleft lip (n = 1). Conclusions: Although statistically insignificant, the detrimental impact of influenza A H1N1pdm09 on pregnancy can be serious in some complicated cases in South Korea. Thus, the strong recommendation of influenza vaccination should be maintained for pregnant women as a high priority.
참고문헌 (39)
- "Influenza (seasonal). Fact sheet no. 211" (2009)[URL]
- "People at high risk of developing flu-related complications" (2016)[URL]
- Louie JK, "Severe 2009 H1N1influenza in pregnant and postpartum women in California", N Engl J Med, 362, pp.27~35 (2010)
- Jamieson DJ, "Emerging infections and pregnancy", Emerg Infect Dis, 12, pp.1638~1643 (2006)
- McNeil SA, "Effect of respiratory hospitalization during pregnancy on infant outcomes", Am J Obstet Gynecol, 204, pp.S54~S57 (2011)
- Mendez-Figueroa H, "Neonatal characteristics and outcomes of pregnancies complicated by influenza infection during the 2009 pandemic", Am J Obstet Gynecol, 204, pp.S58~S63 (2011)
- Harris JW, "Influenza occurring in pregnant women : a statistical study of thirteen hundred and fifty cases", JAMA, 72, pp.978~980 (1919)
- Hardy JM, "The effect of Asian influenza on the outcome of pregnancy, Baltimore, 1957-1958", Am J Public Health Nations Health, 51, pp.1182~1188 (1961)
- Goodnight WH, "Pneumonia in pregnancy", Crit Care Med, 33, pp.S390~S397 (2005)
- Hewagama S, "2009 H1N1 influenza A and pregnancy outcomes in Victoria, Australia", Clin Infect Dis, 50, pp.686~690 (2010)
- Jain S, "Hospitalized patients with 2009 H1N1 influenza in the United States, April-June 2009", N Engl J Med, 361, pp.1935~1944 (2009)
- Dubar G, "French experience of 2009 A", H1N1v influenza in pregnant women, 2010, pp.5, e13112~
- Vaillant L, "Epidemiology of fatal cases associated with pandemic H1N1 influenza 2009", Euro Surveill, 14, pp.19309~ (2009)
- ANZIC Influenza Investigators and Australasian Maternity Outcomes Surveillance System, "Critical illness due to 2009 A", H1N1 influenza in pregnant and postpartum women: population based cohort study, 2010, pp.340, c1279~
- Gerardin P, "Low clinical burden of 2009 pandemic influenza A(H1N1)infection during pregnancy on the island of La Reunion", PLoS One, 5, pp.e10896~ (2010)
- Lim ML, "Influenza A", H1N1(2009)infection in pregnancy : an Asian perspective, 2010, pp.117, 551~556
- Yamada T, "Pandemic(H1N1)2009 in pregnant Japanese women in Hokkaido", J Obstet Gynaecol Res, 38, pp.130~136 (2012)
- Yu H, "Risk factors for severe illness with 2009 pandemic influenza A(H1N1)virus infection in China", Clin Infect Dis, 52, pp.457~465 (2011)
- 김백남, "우리나라 임신부에서 대유행 인플루엔자(H1N1) 2009 감염", Infection and Chemotherapy, 43(1), pp.55~59 (2011), 대한감염학회
- 안준환, "Was 2009 Pandemic Influenza A (H1N1) Mild Among Pregnant Korean Women?", 전남의대학술지, 49(2), pp.96~99 (2013), 의과학연구소
- 허지안, "H1N1 2009으로 사망한 임신부 1예", Infection and Chemotherapy, 43(2), pp.225~228 (2011), 대한감염학회
- 정영호, "질병의 사회·경제적 비용 추계", 예방의학회지, 39(6), pp.499~504 (2006), 대한예방의학회
- The Third Korea National Health and Nutrition Examination Survey (KNHANES III), "Ministry of Health and Welfare", Ministry of Health and Welfare, ~ (2006)
- "Statistical annual report (2009/2010)" (2013)[URL]
- Socioeconomic costs of alcohol and policy issues, "No I", Korea Institute for Health and Social Affairs, 80~82 (1997)
- Creanga AA, "Severity of 2009 pandemic influenza A(H1N1)virus infection in pregnant women", Obstet Gynecol, 115, pp.717~726 (2010)
- Siston AM, "Pandemic 2009 influenza A(H1N1)virus illness among pregnant women in the United States", JAMA, 303, pp.1517~1525 (2010)
- Beck S, "The worldwide incidence of preterm birth : a systematic review of maternal mortality and morbidity", Bull World Health Organ, 88, pp.31~38 (2010)
- "Birth statistics for Korea" (2013)[URL]
- 이중원, "Prevalence of orofacial clefts in Korean live births", Obstetrics & Gynecology Science, 58(3), pp.196~202 (2015), 대한산부인과학회[DOI]
- Jamieson DJ, "H1N12009 influenza virus infection during pregnancy in the USA", Lancet, 374, pp.451~458 (2009)
- Freeman DW, "Deaths from Asian influenza associated with pregnancy", Am J Obstet Gynecol, 78, pp.1172~1175 (1959)
- Neuzil KM, "Impact of influenza on acute cardiopulmonary hospitalizations in pregnant women", Am J Epidemiol, 148, pp.1094~1102 (1998)
- 김미정, "임신부의 인플루엔자 백신 접종률 및 관련요인", Infection and Chemotherapy, 41(6), pp.349~354 (2009), 대한감염학회
- "OECD obesity update 2012" (2012)[URL]
- Rolland-Harris E, "Hospitalization of pregnant women with pandemic A(H1N1)2009influenza in Canada", Epidemiol Infect, 140, pp.1316~1327 (2012)
- La Ruche G, "The 2009 pandemic H1N1 influenza and indigenous populations of the Americas and the Pacific", Euro Surveill, 14, pp.19366~ (2009)
- Miller MA, "The signature features of influenza pandemics : implications for policy", N Engl J Med, 360, pp.2595~2598 (2009)
- Simonsen L, "Global mortality estimates for the 2009 influenza pandemic from the GLaMOR project : a modeling study", PLoS Med, 10, pp.e1001558~ (2013)