Age at menarche and risk of colorectal adenoma
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Background/Aims: Limited data are available regarding the association between age at menarche and the risk of colorectal adenoma. Therefore, we aimed to evaluate the relationship between reproductive factors including age at menarche and the risk of colorectal adenoma. Methods: A cross-sectional study was performed on asymptomatic female subjects who underwent colonoscopy between 2010 and 2014 as part of a comprehensive health screening program in Korea. The association between reproductive factors including age at menarche and the presence of adenomas was assessed using multivariate logistic regression analysis. Results: Among 32,620 asymptomatic female subjects, the proportion of patients with menarche at 10 to 11, 12 to 13, 14 to 15, 16 to 17, and 18 to 19 years of age was 4.1%, 31.7%, 45.4%, 14.9%, and 4.0%, respectively. Age at menarche was not significantly associated with the risk of any adenoma (adjusted odds ratio [AOR], 0.99; 95% confidence interval [CI], 0.97 to 1.02; p = 0.500) or advanced adenoma (AOR, 0.98; 95% CI, 0.91 to 1.04; p = 0.468) after adjusting for confounding factors. Age at menarche was not significantly associated with the risk of adenoma even among similar age groups. In addition, parity, use of female hormones, and menopause were not associated with the risk of adenoma. Conclusions: Age at menarche, parity, use of female hormones, and menopause were not significantly associated with the risk of colorectal adenoma. Our findings indicate that reproductive factors including age at menarche do not affect the development of colorectal adenoma.
Abstract
Background/Aims: Limited data are available regarding the association between age at menarche and the risk of colorectal adenoma. Therefore, we aimed to evaluate the relationship between reproductive factors including age at menarche and the risk of colorectal adenoma. Methods: A cross-sectional study was performed on asymptomatic female subjects who underwent colonoscopy between 2010 and 2014 as part of a comprehensive health screening program in Korea. The association between reproductive factors including age at menarche and the presence of adenomas was assessed using multivariate logistic regression analysis. Results: Among 32,620 asymptomatic female subjects, the proportion of patients with menarche at 10 to 11, 12 to 13, 14 to 15, 16 to 17, and 18 to 19 years of age was 4.1%, 31.7%, 45.4%, 14.9%, and 4.0%, respectively. Age at menarche was not significantly associated with the risk of any adenoma (adjusted odds ratio [AOR], 0.99; 95% confidence interval [CI], 0.97 to 1.02; p = 0.500) or advanced adenoma (AOR, 0.98; 95% CI, 0.91 to 1.04; p = 0.468) after adjusting for confounding factors. Age at menarche was not significantly associated with the risk of adenoma even among similar age groups. In addition, parity, use of female hormones, and menopause were not associated with the risk of adenoma. Conclusions: Age at menarche, parity, use of female hormones, and menopause were not significantly associated with the risk of colorectal adenoma. Our findings indicate that reproductive factors including age at menarche do not affect the development of colorectal adenoma.
참고문헌 (31)
- Ferlay J, "Estimates of worldwide burden of cancer in 2008 : GLOBOCAN 2008", Int J Cancer, 127, pp.2893~2917 (2010)
- Ng SC, "Colorectal cancer screening in Asia", Br Med Bull, 105, pp.29~42 (2013)
- Yoon Kyung Song, M.D., "Alcohol Drinking Increased the Risk of Advanced Colorectal Adenomas", Intestinal research, 13(1), pp.74~79 (2015), 대한장연구학회[DOI]
- 김요한, "Inhibitory Effect of Metformin Therapy on the Incidence of Colorectal Advanced Adenomas in Patients With Diabetes", Intestinal research, 13(2), pp.145~152 (2015), 대한장연구학회
- Ramish Riaz, "Red flag symptoms: detailed account of clinicopathological features in young-onset colorectal cancer", Intestinal research, 15(2), pp.203~207 (2017), 대한장연구학회
- American Cancer Society, "Colorectal Cancer Facts & Figures 2014-2016", American Cancer Society, ~ (2014)
- Hye-Won Park, "Colorectal Neoplasm in Asymptomatic Average-risk Koreans: The KASID Prospective Multicenter Colonoscopy Survey", Gut and Liver, 3(1), pp.35~40 (2009), 거트앤리버 소화기연관학회협의회
- Choe JW, "Screening colonoscopy in asymptomatic average-risk Koreans : analysis in relation to age and sex", J Gastroenterol Hepatol, 22, pp.1003~1008 (2007)
- Murphy G, "Sex disparities in colorectal cancer incidence by anatomic subsite, race and age", Int J Cancer, 128, pp.1668~1675 (2011)
- Irby K, "Emerging and widening colorectal carcinoma disparities between Blacks and Whites in the United States(1975-2002)", Cancer Epidemiol Biomarkers Prev, 15, pp.792~797 (2006)
- McMichael AJ, "Reproduction, endogenous and exogenous sex hormones, and colon cancer : a review and hypothesis", J Natl Cancer Inst, 65, pp.1201~1207 (1980)
- Issa JP, "Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon", Nat Genet, 7, pp.536~540 (1994)
- Li CY, "Age at menarche and risk of colorectal cancer : a meta-analysis", PLoS One, 8, pp.e65645~ (2013)
- Vihko R, "Endocrine characteristics of adolescent menstrual cycles : impact of early menarche", J Steroid Biochem, 20, pp.231~236 (1984)
- Martinez ME, "A prospective study of reproductive factors, oral contraceptive use, and risk of colorectal cancer", Cancer Epidemiol Biomarkers Prev, 6, pp.1~5 (1997)
- Fernandez E, "Oral contraceptives, hormone replacement therapy and the risk of colorectal cancer", Br J Cancer, 73, pp.1431~1435 (1996)
- Akhter M, "Reproductive factors, exogenous female hormone use and colorectal cancer risk : the Japan Public Health Center-based Prospective Study", Eur J Cancer Prev, 17, pp.515~524 (2008)
- Nichols HB, "Oral contraceptive use, reproductive factors, and colorectal cancer risk : findings from Wisconsin", Cancer Epidemiol Biomarkers Prev, 14, pp.1212~1218 (2005)
- Lo AC, "Lifestyle, occupational, and reproductive factors and risk of colorectal cancer", Dis Colon Rectum, 53, pp.830~837 (2010)
- Wen CP, "Are Asians at greater mortality risks for being overweight than Caucasians? Redefining obesity for Asians", Public Health Nutr, 12, pp.497~506 (2009)
- Hamaguchi M, "The severity of ultrasonographic findings in nonalcoholic fatty liver disease reflects the metabolic syndrome and visceral fat accumulation", Am J Gastroenterol, 102, pp.2708~2715 (2007)
- Lieberman DA, "Guidelines for colonoscopy surveillance after screening and polypectomy : a consensus update by the US Multi-Society Task Force on Colorectal Cancer", Gastroenterology, 143, pp.844~857 (2012)
- Di Leo A, "Estrogens and colorectal cancer", Curr Drug Targets Immune Endocr Metabol Disord, 1, pp.1~12 (2001)
- Burkman RT, "Reproductive hormones and cancer : ovarian and colon cancer", Obstet Gynecol Clin North Am, 29, pp.527~540 (2002)
- Apter D, "Some endocrine characteristics of early menarche, a risk factor for breast cancer, are preserved into adulthood", Int J Cancer, 44, pp.783~787 (1989)
- MacMahon B, "Age at menarche, urine estrogens and breast cancer risk", Int J Cancer, 30, pp.427~431 (1982)
- Nanda K, "Hormone replacement therapy and the risk of colorectal cancer: a meta-analysis", Obstet Gynecol, 93(5 Pt 2), pp.880~888 (1999)
- Bosetti C, "Oral contraceptives and colorectal cancer risk : a systematic review and meta-analysis", Hum Reprod Update, 15, pp.489~498 (2009)
- Platz EA, "Parity and other reproductive factors and risk of adenomatous polyps of the distal colorectum(United States)", Cancer Causes Control, 8, pp.894~903 (1997)
- Peipins LA, "Reproductive history, use of exogenous hormones, and risk of colorectal adenomas", Cancer Epidemiol Biomarkers Prev, 6, pp.671~675 (1997)
- Jacobson JS, "Reproductive risk factors for colorectal adenomatous polyps(New York City, NY, United States)", Cancer Causes Control, 6, pp.513~518 (1995)