The effect of susceptibility variants, identified in never-smoking female lung cancer cases, on male smokers
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Background/Aims: Genome wide and candidate gene association studies have identified polymorphisms associated with the risk of lung cancer in never-smokers. This study was conducted to evaluate the association between 11 polymorphisms identified in female never smokers and the lung cancer risk in male smokers. Methods: This study included 714 lung cancer patients and 626 healthy controls. The polymorphisms were genotyped using SEQUENOM MassARRAY iPLEX assay or Taq-Man assay. Results: Two polymorphisms were associated with the risk of lung cancer in male smokers, as in female never smokers. Male smokers carrying the rs4975616 variant allele had a significantly decreased risk of lung cancer (in a codominant model: odds ratio, 0.77; 95% confidence interval, 0.61 to 0.96; p = 0.02). The rs9387478 polymorphism also reduced lung cancer risk in male smokers (in a codominant model: odds ratio, 0.85; 95% confidence interval, 0.73 to 0.997; p = 0.046). In a stratified analysis, the association between these polymorphisms and the risk of lung cancer was predominant in lighter smokers and for cases of adenocarcinoma. Conclusions: These results suggest that a subset of polymorphisms known to be associated with the risk of lung cancer in female never smokers is also associated with the risk of lung cancer in male smokers.
Abstract
Background/Aims: Genome wide and candidate gene association studies have identified polymorphisms associated with the risk of lung cancer in never-smokers. This study was conducted to evaluate the association between 11 polymorphisms identified in female never smokers and the lung cancer risk in male smokers. Methods: This study included 714 lung cancer patients and 626 healthy controls. The polymorphisms were genotyped using SEQUENOM MassARRAY iPLEX assay or Taq-Man assay. Results: Two polymorphisms were associated with the risk of lung cancer in male smokers, as in female never smokers. Male smokers carrying the rs4975616 variant allele had a significantly decreased risk of lung cancer (in a codominant model: odds ratio, 0.77; 95% confidence interval, 0.61 to 0.96; p = 0.02). The rs9387478 polymorphism also reduced lung cancer risk in male smokers (in a codominant model: odds ratio, 0.85; 95% confidence interval, 0.73 to 0.997; p = 0.046). In a stratified analysis, the association between these polymorphisms and the risk of lung cancer was predominant in lighter smokers and for cases of adenocarcinoma. Conclusions: These results suggest that a subset of polymorphisms known to be associated with the risk of lung cancer in female never smokers is also associated with the risk of lung cancer in male smokers.
참고문헌 (20)
- Subramanian J, "Lung cancer in never smokers : a review", J Clin Oncol, 25, pp.561~570 (2007)
- Sun S, "Lung cancer in never smokers : a different disease", Nat Rev Cancer, 7, pp.778~790 (2007)
- Torok S, "Lung cancer in never smokers", Future Oncol, 7, pp.1195~1211 (2011)
- Lan Q, "Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia", Nat Genet, 44, pp.1330~1335 (2012)
- Hsiung CA, "The 5p15. 33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia", PLoS Genet, 6, pp.e1001051~ (2010)
- Wang Y, "Role of 5p15. 33(TERT-CLPTM1L), 6p21. 33 and 15q25. 1(CHRNA5-CHRNA3)variation and lung cancer risk in never-smokers", Carcinogenesis, 31, pp.234~238 (2010)
- Li Y, "Genetic variants and risk of lung cancer in never smokers : a genome-wide association study", Lancet Oncol, 11, pp.321~330 (2010)
- Ahn MJ, "The 18p11. 22 locus is associated with never smoker non-small cell lung cancer susceptibility in Korean populations", Hum Genet, 131, pp.365~372 (2012)
- Hosgood HD 3rd, "Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in Asia", Hum Genet, 131, pp.1197~1203 (2012)
- Kang HG, "A functional polymorphism in CSF1R gene is a novel susceptibility marker for lung cancer among never-smoking females", J Thorac Oncol, 9, pp.1647~1655 (2014)
- Cohen SB, "Protein composition of catalytically active human telomerase from immortal cells", Science, 315, pp.1850~1853 (2007)
- Yamamoto K, "A novel gene, CRR9, which was up-regulated in CDDP-resistant ovarian tumor cell line, was associated with apoptosis", Biochem Biophys Res Commun, 280, pp.1148~1154 (2001)
- McKay JD, "Lung cancer susceptibility locus at 5p15. 33", Nat Genet, 40, pp.1404~1406 (2008)
- Broderick P, "Deciphering the impact of common genetic variation on lung cancer risk : a genome-wide association study", Cancer Res, 69, pp.6633~6641 (2009)
- Petersen GM, "A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22. 1, 1q32. 1 and 5p15. 33", Nat Genet, 42, pp.224~228 (2010)
- Kote-Jarai Z, "Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study", Nat Genet, 43, pp.785~791 (2011)
- Beesley J, "Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers", PLoS One, 6, pp.e24987~ (2011)
- Llorca-Cardenosa MJ, "Long telomere length and a TERT-CLPTM1 locus polymorphism association with melanoma risk", Eur J Cancer, 50, pp.3168~3177 (2014)
- Bergethon K, "ROS1 rearrangements define a unique molecular class of lung cancers", J Clin Oncol, 30, pp.863~870 (2012)
- Han JF, "Polymorphism of rs9387478correlates with overall survival in female nonsmoking patients with lung cancer", Int J Biol Markers, 31, pp.e144~e152 (2016)