Dynamics of viral load and anti-SARS-CoV-2 antibodies in patients with positive RT-PCR results after recovery from COVID-19
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Recently, the number of patients with coronavirus disease 2019 (COVID-19) who have tested positive for severe acute respiratory syndrome coronavirus 2 (SARSCoV- 2), via the reverse transcription polymerase chain reaction (RT-PCR) test, after recovery has increased; this has caused a dilemma regarding the medical measures and policies. We evaluated the dynamics of viral load and anti-SARSCoV- 2 antibodies in four patients with positive RT-PCR results after recovery. In all patients, the highest levels of immunoglobulin G (IgG) and IgM antibodies were reached after about a month of the onset of the initial symptoms. Then, the IgG titers plateaued, and the IgM titers decreased, regardless of RT-PCR results. The IgG and IgM levels did not increase after the post-negative positive RT-PCR results in any of the patients. Our results reinforced that the post-negative positive RT-PCR results may be due to the detection of RNA particles rather than reinfection in individuals who have recovered from COVID-19.
Abstract
Recently, the number of patients with coronavirus disease 2019 (COVID-19) who have tested positive for severe acute respiratory syndrome coronavirus 2 (SARSCoV- 2), via the reverse transcription polymerase chain reaction (RT-PCR) test, after recovery has increased; this has caused a dilemma regarding the medical measures and policies. We evaluated the dynamics of viral load and anti-SARSCoV- 2 antibodies in four patients with positive RT-PCR results after recovery. In all patients, the highest levels of immunoglobulin G (IgG) and IgM antibodies were reached after about a month of the onset of the initial symptoms. Then, the IgG titers plateaued, and the IgM titers decreased, regardless of RT-PCR results. The IgG and IgM levels did not increase after the post-negative positive RT-PCR results in any of the patients. Our results reinforced that the post-negative positive RT-PCR results may be due to the detection of RNA particles rather than reinfection in individuals who have recovered from COVID-19.
참고문헌 (10)
- "Novel coronavirus (2019-nCoV) situation reports" (2020)[URL]
- "Findings from Investigation and analysis of re-positive cases" (2020)[URL]
- Sethuraman N, "Interpreting diagnostic tests for SARS-CoV-2", JAMA, 323, pp.2249~2251 (2020)
- To KK, "Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARSCoV-2 : an observational cohort study", Lancet Infect Dis, 20, pp.565~574 (2020)
- Xiao AT, "Profile of specific antibodies to SARS-CoV-2 : the first report", J Infect, 81, pp.147~178 (2020)
- Li J, "Case report : viral shedding for 60 days in a woman with COVID-19", Am J Trop Med Hyg, 102, pp.1210~1213 (2020)
- Lan L, "Positive RT-PCR test results in patients recovered from COVID-19", JAMA, 323, pp.1502~1503 (2020)
- Atkinson B, "SARS-CoV-2 shedding and infectivity", Lancet, 395, pp.1339~1340 (2020)
- Alvarez-Moreno CA, "Testing dilemmas: post negative, positive SARS-CoV-2 RT-PCR: is it a reinfection?", Travel Med Infect Dis, 35, pp.101743~ (2020)
- Chandrashekar A, "SARS-CoV-2 infection protects against rechallenge in rhesus macaques", Science, 369, pp.812~817 (2020)