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흰쥐를 이용한 실험적 신경근병증에서 비정상자발전위의 발현

The Development of Abnormal Spontaneous Activities in the Experimental Radiculopathy in the Rat

이성재|권범선|현정근|박원범|한태륜
대한재활의학회 (Korean Academy Of Rehabilitation Medicine)|2005.08|Annals of Rehabilitation Medicine|제29권 제4호|pp. 392-397

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참고문헌

주제분류재활의학

초록

Abstract

Objective: Through a animal study using rats, we investigated whether abnormal spontaneous activities (ASAs) could be observed in the radiculopathies of biochemical and mechanical model. Method: A total of 30 Sprague-Dawley male rats were randomly assigned into sham, nucleus pulposus (NP) and ligation groups. In the sham group, the right L4 and L5 nerve roots were exposed by laminectomies. In the NP group, nucleus pulposus was transplanted onto nerve roots from tail. In the ligation group, exposed nerve roots were ligated by silk ligatures. All rats were evaluated by mechanical allodynia, motor paresis, and the needle electromyography (EMG) examination. Results: Mechanical allodynia was observed on the 4th and 7th postoperative days in NP and ligation groups. Motor paresis was observed only in the ligation group. The needle EMG showed ASAs on the 4th postoperative day, but decreased in incidence and amount on the 7th postoperative day in the NP and ligation groups. Conclusion: The ASAs can be observed by the biochemical action of nucleus pulposus as well as the mechanical compression. The results of this study may help explain the discrepancy between radiologic and electrodiagnostic findings.

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