Fasting glucose level and all-cause or cause-specific mortality in Korean adults: a nationwide cohort study
0
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
Background/Aims: Although people with diabetes have been shown to have higher mortality than people without diabetes, there is a lack of data on the association between fasting glucose (FG) levels and cause-specific mortality rates in the general population. Methods: A total of 326,547 Korean adults over 20 years of age, who had received a health checkup between 2006 and 2008 were selected from the Korean National Health Insurance Service sample cohort dataset and followed until 2015. We estimated hazard ratios (HRs) of all-cause mortality and cause-specific mortality relative to various range of FG levels. All causes of death were classified according to International Classification of Diseases (ICD)-10 codes. Results: During follow-up (mean, 8.5 years), a total of 13,536 deaths (mortality rate 4.89/1,000 person-year) occurred; 4,916 deaths from cancer, 2,133 from cardiovascular disease, 762 from infectious disease, 199 from renal disease, and 5,526 from other causes. The overall mortality rate increased with an increase in FG category (HR, 1.78; 95% confidence interval, 1.65 to 1.92; in the ≥ 160 mg/dL). In addition, a J-shaped associations was found between FG levels and all-cause mortality after adjustment for age, sex, smoking, drinking, physical activity, body mass index, diabetes mellitus medication, hypertension, and dyslipidemia. In particular, the risk of cancer-mortality with high FG levels was increased for men but not women. Conclusions: The risk of all-cause and cause-specific mortality showed the tendency to increase when the FG level was outside of the normal range, indicating a J-shaped relationship, in both men and women.
Abstract
Background/Aims: Although people with diabetes have been shown to have higher mortality than people without diabetes, there is a lack of data on the association between fasting glucose (FG) levels and cause-specific mortality rates in the general population. Methods: A total of 326,547 Korean adults over 20 years of age, who had received a health checkup between 2006 and 2008 were selected from the Korean National Health Insurance Service sample cohort dataset and followed until 2015. We estimated hazard ratios (HRs) of all-cause mortality and cause-specific mortality relative to various range of FG levels. All causes of death were classified according to International Classification of Diseases (ICD)-10 codes. Results: During follow-up (mean, 8.5 years), a total of 13,536 deaths (mortality rate 4.89/1,000 person-year) occurred; 4,916 deaths from cancer, 2,133 from cardiovascular disease, 762 from infectious disease, 199 from renal disease, and 5,526 from other causes. The overall mortality rate increased with an increase in FG category (HR, 1.78; 95% confidence interval, 1.65 to 1.92; in the ≥ 160 mg/dL). In addition, a J-shaped associations was found between FG levels and all-cause mortality after adjustment for age, sex, smoking, drinking, physical activity, body mass index, diabetes mellitus medication, hypertension, and dyslipidemia. In particular, the risk of cancer-mortality with high FG levels was increased for men but not women. Conclusions: The risk of all-cause and cause-specific mortality showed the tendency to increase when the FG level was outside of the normal range, indicating a J-shaped relationship, in both men and women.
참고문헌 (38)
- Rao Kondapally Seshasai S, "Diabetes mellitus, fasting glucose, and risk of cause-specific death", N Engl J Med, 364, pp.829~841 (2011)
- Ogata E, "Low fasting plasma glucose level as a predictor of new-onset diabetes mellitus on a large cohort from a Japanese general population", Sci Rep, 8, pp.13927~ (2018)
- Lee CL, "Trajectories of fasting plasma glucose variability and mortality in type 2 diabe tes", Diabetes Metab, 44, pp.121~128 (2018)
- Liu L, "The association between fasting plasma glucose and all-cause and cause-specific mortality by gender: the rural Chinese cohort study", Diabetes Metab Res Rev, 35, pp.e3129~ (2019)
- Kakehi E, "The ratio of fasting plasma glucose to hemoglobin A1c as a predictor of all-cause mortality in individuals with normal glucose levels : the Jichi Medical School cohort study", SAGE Open Med, 7, pp.2050312119860398~ (2019)
- Wang A, "Visit-to-visit variability of fasting plasma glucose and the risk of cardiovascular disease and all-cause mortality in the general population", J Am Heart Assoc, 6, pp.e006757~ (2017)
- Park C, "Fasting glucose level and the risk of incident atherosclerotic cardiovascular diseases", Diabetes Care, 36, pp.1988~1993 (2013)
- Mongraw-Chaffin M, "A prospective study of low fasting glucose with cardiovascular disease events and all-cause mortality : the Women’s Health Initiative", Metabolism, 70, pp.116~124 (2017)
- Yi SW, "Association between fasting glucose and all-cause mortality according to sex and age : a prospective cohort study", Sci Rep, 7, pp.8194~ (2017)
- Xu D, "Fasting plasma glucose variability and all-cause mortality among type 2diabetes patients : a dynamic cohort study in Shanghai, China", Sci Rep, 6, pp.39633~ (2016)
- Liu JJ, "Ethnic disparities in risk of cardiovascular disease, end-stage renal disease and allcause mortality : a prospective study among Asian people with type 2 diabetes", Diabet Med, 33, pp.332~339 (2016)
- Torrens JI, "Ethnic differences in insulin sensitivity and beta-cell function in premenopausal or early perimenopausal women without diabetes : the Study of Women’s Health Across the Nation(SWAN)", Diabetes Care, 27, pp.354~361 (2004)
- Lee JY, "Association of baseline level of physical activity and its temporal changes with incident hypertension and diabetes mellitus", Eur J Prev Cardiol, 25, pp.1065~1073 (2018)
- Paffenbarger RS Jr, "The association of changes in physical-activity level and other lifestyle characteristics with mortality among men", N Engl J Med, 328, pp.538~545 (1993)
- Danaei G, "National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980 : systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2. 7 million participants", Lancet, 378, pp.31~40 (2011)
- GBD 2016 Mortality Collaborators, "Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970-2016: a systematic analysis for the Global Burden of Disease Study 2016", Lancet, 390, pp.1084~1150 (2017)
- Wang H, "Age-specific and sex-specific mortality in 187 countries, 1970-2010 : a systematic analysis for the Global Burden of Disease Study 2010", Lancet, 380, pp.2071~2094 (2012)
- "National Health Insurance Data Sharing Service" (2019)[URL]
- Eun Jin Na, "Risks of Completed Suicide of Community Individuals with ICD-10 Disorders Across Age Groups: A Nationwide Population-Based Nested Case-Control Study in South Korea", PSYCHIATRY INVESTIGATION, 16(4), pp.314~324 (2019), 대한신경정신의학회[DOI]
- Lee J, "Cohort profile : the National Health Insurance Service-National Sample Cohort(NHIS-NSC), South Korea", Int J Epidemiol, 46, pp.e15~ (2017)
- American Diabetes Association, "Classification and diagnosis of diabetes: standards of medical care in diabetes", Diabetes Care, 42(Suppl 1), pp.S13~S28 (2019)
- "Korean Statistical Classification of Diseases" (1996)[URL]
- DECODE Study Group, "Is the current definition for diabetes relevant to mortality risk from all causes and cardiovascular and noncardiovascular diseases?", Diabetes Care, 26, pp.688~696 (2003)
- Wei M, "Low fasting plasma glucose level as a predictor of cardiovascular disease and all-cause mortality", Circulation, 101, pp.2047~2052 (2000)
- Liao HW, "Low fasting glucose and future risks of major adverse outcomes in people without baseline diabetes or cardiovascular disease : a systematic review and meta-analysis", BMJ Open, 9, pp.e026010~ (2019)
- Ning F, "Cardiovascular disease mortality in Europeans in relation to fasting and 2-h plasma glucose levels within a normoglycemic range", Diabetes Care, 33, pp.2211~2216 (2010)
- Emerging Risk Factors Collaboration, "Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease : a collaborative meta-analysis of 102 prospective studies", Lancet, 375, pp.2215~2222 (2010)
- Tanne D, "Fasting plasma glucose and risk of incident ischemic stroke or transient ischemic attacks : a prospective cohort study", Stroke, 35, pp.2351~2355 (2004)
- Preiss D, "Fasting plasma glucose in non-diabetic participants and the risk for incident cardiovascular events, diabetes, and mortality : results from WOSCOPS 15-year follow-up", Eur Heart J, 31, pp.1230~1236 (2010)
- Selvin E, "Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults", N Engl J Med, 362, pp.800~811 (2010)
- Bjornholt JV, "Fasting blood glucose : an underestimated risk factor for cardiovascular death. Results from a 22-year follow-up of healthy nondiabetic men", Diabetes Care, 22, pp.45~49 (1999)
- Jee SH, "Fasting serum glucose level and cancer risk in Korean men and women", JAMA, 293, pp.194~202 (2005)
- Perseghin G, "Insulin resistance", hyperinsulinemia and cancer mortality : the Cremona study at the 15th year of follow-up, 2012, pp.49, 421~428
- Grossmann M, "Testosterone and glucose metabolism in men : current concepts and controversies", J Endocrinol, 220, pp.R37~R55 (2014)
- Fox CS, "Abdominal visceral and subcutaneous adipose tissue compartments : association with metabolic risk factors in the Framingham Heart Study", Circulation, 116, pp.39~48 (2007)
- Kalyani RR, "Glucose and insulin measurements from the oral glucose tolerance test and relationship to muscle mass", J Gerontol A Biol Sci Med Sci, 67, pp.74~81 (2012)
- Afkarian M, "Kidney disease and increased mortality risk in type 2 diabetes", J Am Soc Nephrol, 24, pp.302~308 (2013)
- Davidson JA, "SGLT2 inhibitors in patients with type 2diabetes and renal disease : overview of current evidence", Postgrad Med, 131, pp.251~260 (2019)