Treatment of Transient Osteoporosis of the Hip with Intravenous Zoledronate - A Case Report -
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Transient osteoporosis of the hip (TOH) is a rare disorder of unknown etiology that is characterized by acute onset of disabling bone pain. The locally increased bone turnover and low bone mineral density (BMD) associated with this disorder indicate a potential role for an antiresorptive agent such as bisphosphonate as a treatment. A previously healthy 46-year-old man developed the sudden onset of pain in his right buttock and inguinal area,especially during walking and caused him to limp. A thorough medical workup including X-ray, MRI, and bone SPECT revealed transient osteoporosis of the hip, and he was treated with an infusion of zoledronate (5 mg). Two weeks later, he was fully recovered from pain and the gait disturbance. A follow-up MRI of the hip joint taken after 6 months showed complete resolution. The use of intravenous zoledronate provided a successful outcome in the treatment of TOH. The possibility of TOH should be considered in patients complaining of sudden hip pain and a limping gait. MR imaging played an important role for diff erentiation of TOH from other aggressive conditions with long term sequelae.
Abstract
Transient osteoporosis of the hip (TOH) is a rare disorder of unknown etiology that is characterized by acute onset of disabling bone pain. The locally increased bone turnover and low bone mineral density (BMD) associated with this disorder indicate a potential role for an antiresorptive agent such as bisphosphonate as a treatment. A previously healthy 46-year-old man developed the sudden onset of pain in his right buttock and inguinal area,especially during walking and caused him to limp. A thorough medical workup including X-ray, MRI, and bone SPECT revealed transient osteoporosis of the hip, and he was treated with an infusion of zoledronate (5 mg). Two weeks later, he was fully recovered from pain and the gait disturbance. A follow-up MRI of the hip joint taken after 6 months showed complete resolution. The use of intravenous zoledronate provided a successful outcome in the treatment of TOH. The possibility of TOH should be considered in patients complaining of sudden hip pain and a limping gait. MR imaging played an important role for diff erentiation of TOH from other aggressive conditions with long term sequelae.
참고문헌 (10)
- Korompilias AV, "Bone marrow edema syndrome", Skeletal Radiol, 38, pp.425~436 (2009)
- Ringe JD, "Effective and rapid treatment of painful localized transient osteoporosis (bone marrow edema) with intravenous ibandronate", Osteoporos Int, 16, pp.2063~2068 (2005)
- Varenna M, "Intravenous pamidronate in the treatment of transient osteoporosis of the hip", Bone, 31, pp.96~101 (2002)
- Daniel WW, "The early diagnosis of transient osteoporosis by magnetic resonance imaging. A case report", J Bone Joint Surg Am, 74, pp.1262~1264 (1992)
- Guerra JJ, "Distinguishing transient osteoporosis from avascular necrosis of the hip", J Bone Joint Surg Am, 77, pp.616~624 (1995)
- Fabbriciani G, "Transient osteoporosis of the hip: successful treatment with teriparatide" (2010), Rheumatol Int
- Hayes CW, "MR imaging of bone marrow edema pattern: transient osteoporosis, transient bone marrow edema syndrome, or osteonecrosis", Radiographics, 13, pp.1001~1012 (1993)
- Parker RK, "Transient osteoporosis of the knee", Skeletal Radiol, 26, pp.306~309 (1997)
- Schapira D, "Severe transient osteoporosis of the hip during pregnancy. Successful treatment with intravenous biphosphonates", Clin Exp Rheumatol, 21, pp.107~110 (2003)
- Miyanishi K, "A subchondral fracture in transient osteoporosis of the hip", Skeletal Radiol, 36, pp.677~680 (2007)