Association between oral health and hyperuricemia in Korean adults: Korea National Health and Nutrition Examination Survey 2016–2019
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Background/Aims: Hyperuricemia plays an essential role in the gout. Despite the clinical significance of hyperuricemia, a direct relationship between oral health and hyperuricemia has not been established. We aim to investigate the association between oral health and hyperuricemia. Methods: We selected 17,557 subjects from the Korea National Health and Nutrition Examination Survey database for the years 2016–2019. Oral health-related variables included the number of dental caries, regular tooth brushing, use of secondary oral products, and regular dental examinations. The odds ratio (OR) and 95% confidence intervals (CIs) for hyperuricemia were calculated using a multivariable-adjusted logistic regression model. Results: Oral health status with dental caries and oral health behaviors, including tooth brushing, secondary oral products, and regular dental examination, were significantly associated with hyperuricemia in all participants. The adjusted OR and 95% CIs for hyperuricemia comparing more than three dental caries with no dental caries were 1.28 (1.08–1.52). The adjusted OR and 95% CIs for hyperuricemia in regular tooth brushing, use of secondary oral products, and regular dental examination were 0.78 (0.67–0.91), 0.91 (0.83–1.00), and 0.86 (0.78–0.95), respectively. Notably, the association between oral health and hyperuricemia was more prominent in male subjects. In addition, when subjects were grouped by the oral health scoring system, the prevalence of hyperuricemia was lower in groups with better oral health scores. Conclusions: We demonstrated that oral health status and behaviors are associated with hyperuricemia, particularly in males. Further studies are necessary to confirm the association between oral health and hyperuricemia.
Abstract
Background/Aims: Hyperuricemia plays an essential role in the gout. Despite the clinical significance of hyperuricemia, a direct relationship between oral health and hyperuricemia has not been established. We aim to investigate the association between oral health and hyperuricemia. Methods: We selected 17,557 subjects from the Korea National Health and Nutrition Examination Survey database for the years 2016–2019. Oral health-related variables included the number of dental caries, regular tooth brushing, use of secondary oral products, and regular dental examinations. The odds ratio (OR) and 95% confidence intervals (CIs) for hyperuricemia were calculated using a multivariable-adjusted logistic regression model. Results: Oral health status with dental caries and oral health behaviors, including tooth brushing, secondary oral products, and regular dental examination, were significantly associated with hyperuricemia in all participants. The adjusted OR and 95% CIs for hyperuricemia comparing more than three dental caries with no dental caries were 1.28 (1.08–1.52). The adjusted OR and 95% CIs for hyperuricemia in regular tooth brushing, use of secondary oral products, and regular dental examination were 0.78 (0.67–0.91), 0.91 (0.83–1.00), and 0.86 (0.78–0.95), respectively. Notably, the association between oral health and hyperuricemia was more prominent in male subjects. In addition, when subjects were grouped by the oral health scoring system, the prevalence of hyperuricemia was lower in groups with better oral health scores. Conclusions: We demonstrated that oral health status and behaviors are associated with hyperuricemia, particularly in males. Further studies are necessary to confirm the association between oral health and hyperuricemia.
참고문헌 (38)
- Kim SY, "Hyperuricemia and coronary heart disease : a systematic review and meta-analysis", Arthritis Care Res(Hoboken), 62, pp.170~180 (2010)
- Grayson PC, "Hyperuricemia and incident hypertension : a systematic review and meta-analysis", Arthritis Care Res(Hoboken), 63, pp.102~110 (2011)
- Kim SY, "Hyperuricemia and risk of stroke : a systematic review and meta-analysis", Arthritis Rheum, 61, pp.885~892 (2009)
- Carnethon MR, "Risk factors for progression to incident hyperinsulinemia : the Atherosclerosis Risk in Communities Study, 1987-1998", Am J Epidemiol, 158, pp.1058~1067 (2003)
- Kim Y, "Prevalence of hyperuricemia and its associated factors in the general Korean population : an analysis of a population-based nationally representative sample", Clin Rheumatol, 37, pp.2529~2538 (2018)
- Krishnan E, "Interaction of inflammation, hyperuricemia, and the prevalence of hypertension among adults free of metabolic syndrome : NHANES 2009-2010", J Am Heart Assoc, 3, pp.e000157~ (2014)
- Park JS, "Trends of gout prevalence in South Korea based on medical utilization : a National Health Insurance Service Database(2002~2015)", J Rheum Dis, 27, pp.174~181 (2020)
- Loesche WJ, "Association of the oral flora with important medical diseases", Curr Opin Periodontol, 4, pp.21~28 (1997)
- Yoneyama T, "Oral care and pneumonia. Oral Care Working Group", Lancet, 354, pp.515~ (1999)
- Park SY, "Improved oral hygiene care attenuates the cardiovascular risk of oral health disease : a population-based study from Korea", Eur Heart J, 40, pp.1138~1145 (2019)
- Jepsen S, "Prevention and control of dental caries and periodontal diseases at individual and population level : consensus report of group 3 of joint EFP", ORCA workshop on the boundaries between caries and periodontal diseases, 2017, pp.44(Suppl 18), S85~S93
- "Korea National Health and Nutrition Examination Survey" (2023)[URL]
- Kweon S, "Data resource profile : the Korea National Health and Nutrition Examination Survey(KNHANES)", Int J Epidemiol, 43, pp.69~77 (2014)
- Kragh Ekstam A, "Oral health status using the revised oral assessment guide and mortality in older orthopaedic patients : a cross-sectional study", Clin Interv Aging, 18, pp.1103~1113 (2023)
- Busby M, "Continuing development of an oral health score for clinical audit", Br Dent J, 216, pp.E20~ (2014)
- Levey AS, "A more accurate method to estimate glomerular filtration rate from serum creatinine : a new prediction equation. Modification of Diet in Renal Disease Study Group", Ann Intern Med, 130, pp.461~470 (1999)
- Bardin T, "Definition of hyperuricemia and gouty conditions", Curr Opin Rheumatol, 26, pp.186~191 (2014)
- Lee HY, "2018 Korean Society of Hypertension Guidelines for the management of hypertension : part II-diagnosis and treatment of hypertension", Clin Hypertens, 25, pp.20~ (2019)
- Kim MK, "2019 Clinical Practice Guidelines for type 2 diabetes mellitus in Korea", Diabetes Metab J, 43, pp.398~406 (2019)
- Rhee EJ, "2018 Guidelines for the management of dyslipidemia", Korean J Intern Med, 34, pp.723~771 (2019)
- Byun SH, "Analyzing the association between hyperuricemia and periodontitis : a cross-sectional study using KoGES HEXA data", Int J Environ Res Public Health, 17, pp.4777~ (2020)
- Banu S, "Correlation of Toll-like receptor 4, interleukin-18, transaminases, and uric acid in patients with chronic periodontitis and healthy adults", J Periodontol, 86, pp.431~439 (2015)
- Sampaio-Maia B, "The oral microbiome in health and its implication in oral and systemic diseases", Adv Appl Microbiol, 97, pp.171~210 (2016)
- Liu J, "Analysis of oral microbiota revealed high abundance of prevotella intermedia in gout patients", Cell Physiol Biochem, 49, pp.1804~1812 (2018)
- Cui Y, "Relationship between hyperuricemia and haar-like features on tongue images", Biomed Res Int, 2015, pp.363216~ (2015)
- Lopes MP, "Prevotella intermedia and periodontitis are associated with severe asthma", J Periodontol, 91, pp.46~54 (2020)
- Jia G, "The oral microbiota-a mechanistic role for systemic diseases", Br Dent J, 224, pp.447~455 (2018)
- Eberhard J, "Streptococcus mitis and Gemella haemolysans were simultaneously found in atherosclerotic and oral plaques of elderly without periodontitis-a pilot study", Clin Oral Investig, 21, pp.447~452 (2017)
- Huck O, "Evaluating periodontal risk for patients at risk of or suffering from atherosclerosis : recent biological hypotheses and therapeutic consequences", Arch Cardiovasc Dis, 104, pp.352~358 (2011)
- Ebersole JL, "Microbiologic and immunologic characteristics of periodontal disease in Hispanic americans with type 2 diabetes", J Periodontol, 79, pp.637~646 (2008)
- Agbaje HO, "Digit sucking, age, sex, and socioeconomic status as determinants of oral hygiene status and gingival health of children in suburban Nigeria", J Periodontol, 87, pp.1047~1056 (2016)
- Zhang X, "The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment", Nat Med, 21, pp.895~905 (2015)
- Sheng S, "Structural and functional alterations of gut microbiota in males with hyperuricemia and high levels of liver enzymes", Front Med(Lausanne), 8, pp.779994~ (2021)
- Singhal S, "The role of oral hygiene in inflammatory bowel disease", Dig Dis Sci, 56, pp.170~175 (2011)
- Barboza-Solís C, "The oral microbiota : a literature review for updating professionals in dentistry. Part I", Odovtos Int J Dent Sci, 22, pp.59~68 (2020)
- Muñoz Aguilera E, "Periodontitis is associated with hypertension : a systematic review and meta-analysis", Cardiovasc Res, 116, pp.28~39 (2020)
- Kobayashi Y, "Oral health behavior and metabolic syndrome and its components in adults", J Dent Res, 91, pp.479~484 (2012)
- Doke M, "Effect of dental intervention on improvements in metabolic syndrome patients : a randomized controlled clinical trial", BMC Oral Health, 21, pp.4~ (2021)