Concomitant Occurrence of Cervical Myelopathy, Cerebral Infarction, and Peripheral Neuropathy in Systemic Lupus Erythematosus: A Case Report
1
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease characterized by multiorgan involvement with diverse clinical presentations. Central nervous system involvement in neuropsychiatric syndromes of SLE (NPSLE), such as cerebrovascular disease and myelopathy, is a major cause of morbidity and mortality in SLE patients. The concomitant occurrence of myelopathy, cerebrovascular disease, and peripheral neuropathy in a patient with SLE has not yet been reported. We report on a 41-year-old woman with SLE who showed motor and sensory impairment with urinary retention and was diagnosed with cervical myelopathy and acute cerebral infarction by spine and brain magnetic resonance imaging and peripheral neuropathy by electrodiagnostic examination. Even though pathogenesis of NPSLE is not well elucidated, we assume that increased antibodies of anti-double stranded DNA (anti-dsDNA), presence of lupus anticoagulant and hypertension are risk factors that have caused neuropsychiatric lupus in this patient.
Abstract
Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease characterized by multiorgan involvement with diverse clinical presentations. Central nervous system involvement in neuropsychiatric syndromes of SLE (NPSLE), such as cerebrovascular disease and myelopathy, is a major cause of morbidity and mortality in SLE patients. The concomitant occurrence of myelopathy, cerebrovascular disease, and peripheral neuropathy in a patient with SLE has not yet been reported. We report on a 41-year-old woman with SLE who showed motor and sensory impairment with urinary retention and was diagnosed with cervical myelopathy and acute cerebral infarction by spine and brain magnetic resonance imaging and peripheral neuropathy by electrodiagnostic examination. Even though pathogenesis of NPSLE is not well elucidated, we assume that increased antibodies of anti-double stranded DNA (anti-dsDNA), presence of lupus anticoagulant and hypertension are risk factors that have caused neuropsychiatric lupus in this patient.
참고문헌 (9)
- 박성환, "전신성 홍반성 루푸스", 대한의사협회지, 52(7), pp.645~656 (2009), 대한의사협회
- American College of Rheumatology, "The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes", Arthritis Rheum, 42, pp.599~608 (1999)
- van Dam AP, "Diagnosis and pathogenesis of CNS lupus", Rheumatol Int, 11, pp.1~11 (1991)
- Futrell N, "Frequency, etiology, and prevention of stroke in patients with systemic lupus erythematosus", Stroke, 20, pp.583~591 (1989)
- Łukjanowicz M, "Myelitis in the course of systemic lupus erythematosus: review", Pol Arch Med Wewn, 119, pp.67~72 (2009)
- Florica B, "Peripheral neuropathy in patients with systemic lupus erythematosus", Semin Arthritis Rheum, 41, pp.203~211 (2011)
- Stahl HD, "Central nervous system lupus:concomitant occurrence of myelopathy and cognitive dysfunction", Clin Rheumatol, 13, pp.273~279 (1994)
- Govoni M, "Factors and comorbidities associated with first neuropsychiatric event in systemic lupus erythematosus: does a risk profile exist? A large multicentre retrospective cross-sectional study on 959Italian patients", Rheumatology (Oxford), 51, pp.157~168 (2012)
- Liveson JA, "Laboratory reference for clinical neurophysiology" (1992), F.A. Davis