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Analysis of thromboembolic events in head and neck cancer patients who underwent concurrent chemoradiotherapy with cisplatin

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Background/Aims: The study investigated the incidence of thromboembolic events (TEE) in head and neck (H&N) cancer patients who received concurrent chemoradiotherapy (CCRT) with cisplatin, and analyzed the factors affecting TEE occurrence Methods: Two hundred and fifty-seven patients who started CCRT with cisplatin for H&N cancer from January 2005 to December 2019 were analyzed. Results: TEE occurred in five patients, an incidence rate of 1.9%. The 2-, 4-, and 6-month cumulative incidences of TEE were 0.8%, 1.6%, and 1.9%, respectively. Khorana score was the only factor associated with TEE occurrence (p = 0.010). Conclusions: The incidence of TEE in H&N cancer patients who underwent CCRT with cisplatin was relatively low when compared to other types of cancer. However, patients with a high Khorana score require more careful surveillance for possible TEE occurrence.

Abstract

Background/Aims: The study investigated the incidence of thromboembolic events (TEE) in head and neck (H&N) cancer patients who received concurrent chemoradiotherapy (CCRT) with cisplatin, and analyzed the factors affecting TEE occurrence Methods: Two hundred and fifty-seven patients who started CCRT with cisplatin for H&N cancer from January 2005 to December 2019 were analyzed. Results: TEE occurred in five patients, an incidence rate of 1.9%. The 2-, 4-, and 6-month cumulative incidences of TEE were 0.8%, 1.6%, and 1.9%, respectively. Khorana score was the only factor associated with TEE occurrence (p = 0.010). Conclusions: The incidence of TEE in H&N cancer patients who underwent CCRT with cisplatin was relatively low when compared to other types of cancer. However, patients with a high Khorana score require more careful surveillance for possible TEE occurrence.

참고문헌 (30)

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관련 논문AI추천

Erratum : Analysis of thromboembolic events in head and neck cancer patients who underwent concurrent chemoradiotherapy with cisplatinChul-Ho Kim, Hundo Cho, Hyun Woo Lee, Jaesung Heo, Jeon Yeob Jang, Jin-Hyuk Choi, Mi Sun Ahn, Seok Yun Kang, Seung Soo Sheen, Tae-Hwan Kim, Yong Won Choi, Yoo Seob Shin, Young-Taek Oh대한내과학회 · The Korean Journal of Internal Medicine2022 · 제37권 제6호Cisplatin-Based Chemotherapy Is a Strong Risk Factor for Thromboembolic Events in Small-Cell Lung Cancer김동완, 김인호, 김태민, 이근욱, 이세훈, 이윤규, 이은영, 허대석대한암학회 · Cancer Research and Treatment2015 · 제47권 제4호Concurrent Chemoradiation with Low-Dose Weekly Cisplatin in Locally Advanced Stage IV Head and Neck Squamous Cell Carcinoma강기문, 강명희, 강정훈, 김진평, 박정제, 송하나, 우승훈, 정배권, 채규영대한암학회 · Cancer Research and Treatment2015 · 제47권 제3호Incidental Statin Use and the Risk of Stroke or Transient Ischemic Attack after Radiotherapy for Head and Neck CancerAnnie W. Chan, Bálint Szilveszter, Daniel Addison, Francesca N. Delling, Hamed Emami, Hang Lee, Javier M. Romero, Lori J. Wirth, Matthew G. Nayor, Michael Lu, Negar Mousavi, Orla Hennessy, Patrick R. Lawler, Pedro V. Staziaki, Sumbal A. Janjua,, Tomas G. Neilan, Travis R. Hallett, Udo Hoffmann대한뇌졸중학회 · 대한뇌졸중영문학회지2018 · 제20권 제1호Analysis of the Prognostic Factors for Distant Metastasis after Induction Chemotherapy Followed by Concurrent Chemoradiotherapy for Head and Neck Cancer기용간, 김동원, 김동현, 김원택, 남지호, 설영미, 이병주, 이주혜, 이진춘, 최영진대한암학회 · Cancer Research and Treatment2015 · 제47권 제1호The Efficacy of an Induction Chemotherapy Combination with Docetaxel, Cisplatin, and 5-FU Followed by Concurrent Chemoradiotherapy in Advanced Head and Neck Cancer김여경, 김형준, 양덕환, 이제중, 이준규, 임상철, 정웅기, 정익주, 조상희, Jae-Sook Ahn, Ok-Ki Kim대한암학회 · Cancer Research and Treatment2007 · 제39권 제3호

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