Prevalence of chronic rhinosinusitis and its relating factors in patients with bronchiectasis: findings from KMBARC registry
0
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
Background/Aims: Patients with bronchiectasis often present with respiratory symptoms caused by chronic rhinosinusitis (CRS). However, studies on the prevalence of CRS and its relationship with bronchiectasis are limited. Methods: The baseline characteristics of patients with bronchiectasis recruited from the Korean Multicenter Bronchiectasis Audit and Research Collaboration were analyzed. CRS diagnosis was determined by a physician, on the basis of medical records, upper airway symptoms, and/or radiologic abnormalities. Questionnaires for quality of life, fatigue, and depression were administered when patients were stable for a minimum of 4 weeks after the bronchiectasis exacerbation. Results: The prevalence of CRS was 7.1% (66/931). Patients with CRS were significantly younger than those without CRS (60.5 ± 10.7 years vs. 64.6 ± 9.3 years, p = 0.001). Idiopathic bronchiectasis was more common in patients with CRS compared to those without CRS (53.0% vs. 36.0%, p = 0.006). Lung function, inflammatory markers, exacerbations, bronchiectasis severity, and scores for quality of life, fatigue, and depression did not differ between the two groups. In a logistic regression analysis, CRS was associated with age of bronchiectasis diagnosis (odds ratio [OR], 0.96; 95% confidence interval [CI], 0.94 to 0.99; p = 0.003) and idiopathic bronchiectasis (OR, 1.95; 95% CI, 1.12 to 3.34; p = 0.018). Conclusions: The prevalence of CRS was relatively low. CRS was not associated with the severity or clinical outcomes of bronchiectasis. Early diagnosis and idiopathic etiology were associated with CRS. Our findings reflect the low recognition of CRS in the clinical practice of bronchiectasis and highlight the need for awareness of CRS by adopting objective diagnostic criteria.
Abstract
Background/Aims: Patients with bronchiectasis often present with respiratory symptoms caused by chronic rhinosinusitis (CRS). However, studies on the prevalence of CRS and its relationship with bronchiectasis are limited. Methods: The baseline characteristics of patients with bronchiectasis recruited from the Korean Multicenter Bronchiectasis Audit and Research Collaboration were analyzed. CRS diagnosis was determined by a physician, on the basis of medical records, upper airway symptoms, and/or radiologic abnormalities. Questionnaires for quality of life, fatigue, and depression were administered when patients were stable for a minimum of 4 weeks after the bronchiectasis exacerbation. Results: The prevalence of CRS was 7.1% (66/931). Patients with CRS were significantly younger than those without CRS (60.5 ± 10.7 years vs. 64.6 ± 9.3 years, p = 0.001). Idiopathic bronchiectasis was more common in patients with CRS compared to those without CRS (53.0% vs. 36.0%, p = 0.006). Lung function, inflammatory markers, exacerbations, bronchiectasis severity, and scores for quality of life, fatigue, and depression did not differ between the two groups. In a logistic regression analysis, CRS was associated with age of bronchiectasis diagnosis (odds ratio [OR], 0.96; 95% confidence interval [CI], 0.94 to 0.99; p = 0.003) and idiopathic bronchiectasis (OR, 1.95; 95% CI, 1.12 to 3.34; p = 0.018). Conclusions: The prevalence of CRS was relatively low. CRS was not associated with the severity or clinical outcomes of bronchiectasis. Early diagnosis and idiopathic etiology were associated with CRS. Our findings reflect the low recognition of CRS in the clinical practice of bronchiectasis and highlight the need for awareness of CRS by adopting objective diagnostic criteria.
참고문헌 (38)
- Chalmers JD, "Bronchiectasis", Nat Rev Dis Primers, 4, pp.45~ (2018)
- McShane PJ, "Bronchiectasis", Chest, 155, pp.825~833 (2019)
- Yii AC, "Precision medicine in united airways disease : a"treatable traits"approach", Allergy, 73, pp.1964~1978 (2018)
- Licari A, "The nose and the lung : united airway disease?", Front Pediatr, 5, pp.44~ (2017)
- Orlandi RR, "International consensus statement on allergy and rhinology : rhinosinusitis", Int Forum Allergy Rhinol, 6(Suppl 1), pp.S22~S209 (2016)
- Handley E, "Prevalence and clinical implications of chronic rhinosinusitis in people with bronchiectasis : a systematic review", J Allergy Clin Immunol Pract, 7, pp.2004~2012 (2019)
- Lee H, "KMBARC registry : protocol for a multicentre observational cohort study on non-cystic fibrosis bronchiectasis in Korea", BMJ Open, 10, pp.e034090~ (2020)
- Lee H, "Characteristics of bronchiectasis in Korea : first data from the Korean Multicentre Bronchiectasis Audit and Research Collaboration registry and comparison with other international registries", Respirology, 26, pp.619~621 (2021)
- Hill AT, "Pulmonary exacerbation in adults with bronchiectasis : a consensus definition for clinical research", Eur Respir J, 49, pp.1700051~ (2017)
- ReiffDB, "CT findings in bronchiectasis : limited value in distinguishing between idiopathic and specific types", AJR Am J Roentgenol, 165, pp.261~267 (1995)
- Chalmers JD, "The bronchiectasis severity index : an international derivation and validation study", Am J Respir Crit Care Med, 189, pp.576~585 (2014)
- Minov J, "Assessment of the non-cystic fibrosis bronchiectasis severity : the FACED Score vs the Bronchiectasis Severity Index", Open Respir Med J, 9, pp.46~51 (2015)
- Spinou A, "The development and validation of the Bronchiectasis Health Questionnaire", Eur Respir J, 49, pp.1601532~ (2017)
- 김현국, "Validation of the Korean Version of the Bronchiectasis Health Questionnaire", Tuberculosis and Respiratory Diseases, 83(3), pp.228~233 (2020), 대한결핵및호흡기학회[DOI]
- Krupp LB, "The fatigue severity scale : application to patients with multiple sclerosis and systemic lupus erythematosus", Arch Neurol, 46, pp.1121~1123 (1989)
- Hjollund NH, "Assessment of fatigue in chronic disease : a bibliographic study of fatigue measurement scales", Health Qual Life Outcomes, 5, pp.12~ (2007)
- 박승진, "한글판 우울증 선별도구(Patient Health Questionnaire-9, PHQ-9)의 신뢰도와 타당도", 대한불안의학회지, 6(2), pp.119~124 (2010), 대한불안의학회
- King PT, "Characterisation of the onset and presenting clinical features of adult bronchiectasis", Respir Med, 100, pp.2183~2189 (2006)
- Yang X, "Chronic rhinosinusitis is associated with higher prevalence and severity of bronchiectasis in patients with COPD", Int J Chron Obstruct Pulmon Dis, 12, pp.655~662 (2017)
- Wang Y, "Effects of functional endoscopic sinus surgery on the treatment of bronchiectasis combined with chronic rhino-sinusitis", Acta Otolaryngol, 136, pp.860~863 (2016)
- Guilemany JM, "The impact of bronchiectasis associated to sinonasal disease on quality of life", Respir Med, 100, pp.1997~2003 (2006)
- Guan WJ, "Impacts of co-existing chronic rhinosinusitis on disease severity and risks of exacerbations in Chinese adults with bronchiectasis", PLoS One, 10, pp.e0137348~ (2015)
- Guilemany JM, "The importance of smell in patients with bronchiectasis", Respir Med, 105, pp.44~49 (2011)
- Guilemany JM, "United airways again : high prevalence of rhinosinusitis and nasal polyps in bronchiectasis", Allergy, 64, pp.790~797 (2009)
- Guilemany JM, "United airways : the impact of chronic rhinosinusitis and nasal polyps in bronchiectasic patient’s quality of life", Allergy, 64, pp.1524~1529 (2009)
- Fokkens WJ, "European position paper on rhinosinusitis and nasal polyps 2020", Rhinology, 58(Suppl S29), pp.1~464 (2020)
- McDonnell MJ, "Comorbidities and the risk of mortality in patients with bronchiectasis : an international multicentre cohort study", Lancet Respir Med, 4, pp.969~979 (2016)
- Choi H, "Population-based prevalence of bronchiectasis and associated comorbidities in South Korea", Eur Respir J, 54, pp.1900194~ (2019)
- Araujo D, "The independent contribution of Pseudomonas aeruginosa infection to long-term clinical outcomes in bronchiectasis", Eur Respir J, 51, pp.1701953~ (2018)
- Dhar R, "Bronchiectasis in India : results from the European Multicentre Bronchiectasis Audit and Research Collaboration(EMBARC)and Respiratory Research Network of India Registry", Lancet Glob Health, 7, pp.e1269~e1279 (2019)
- Visser SK, "Australian adults with bronchiectasis : the first report from the Australian Bronchiectasis Registry", Respir Med, 155, pp.97~103 (2019)
- Xu Y, "Prevalence and incidence of diagnosed chronic rhinosinusitis in Alberta, Canada", JAMA Otolaryngol Head Neck Surg, 142, pp.1063~1069 (2016)
- Dietz de Loos D, "Prevalence of chronic rhinosinusitis in the general population based on sinus radiology and symptomatology", J Allergy Clin Immunol, 143, pp.1207~1214 (2019)
- 김도현, "Effect of Chronic Rhinosinusitis With or Without Nasal Polyp on Quality of Life in South Korea: 5th Korea National Health and Nutrition Examination Survey Korean", Clinical and Experimental Otorhinolaryngology, 9(2), pp.150~156 (2016), 대한이비인후과학회[DOI]
- Shoemark A, "Aetiology in adult patients with bronchiectasis", Respir Med, 101, pp.1163~1170 (2007)
- Schwartz BS, "Strong and consistent associations of precedent chronic rhinosinusitis with risk of non-cystic fibrosis bronchiectasis", J Allergy Clin Immunol (2022)[DOI]
- Won HK, "Age-related prevalence of chronic rhinosinusitis and nasal polyps and their relationships with asthma onset", Ann Allergy Asthma Immunol, 120, pp.389~394 (2018)
- Kanda A, "Regulation of interaction between the upper and lower airways in united airway disease", Med Sci(Basel), 7, pp.27~ (2019)