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A combination of PG490 and lipopolysaccharide induce apoptosis through activation of casapase-3 and down-regulation of cIAP1 and XIAP in human astroglioma cell

박종욱|우경진|권택규|이태진
대한면역학회 (The Korean Association of Immunologists)|2005.06|Immune Network|제5권 제2호|pp. 99-104

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Abstract

Background: Malignant gliomas are the most common primary tumors in the central nervous system. Methods: We investigated the combined effect of PG490 and LPS on the induction of the apoptotic pathway in human astroglioma cells. Results: Treatment of U87 cells with combination of 50 nM of PG490 and 50μg/ml of LPS resulted in increased internucleosomal DNA fragmentation, cleavage of PLC-γ1, and down- regulation of cIAP1 and XIAP. The combination of LPS and PG490 treatment-induced apoptosis is mediated through the activation of caspase, which is inhibited by the caspase inhibitor, z-VAD-fmk. Also, release of cytochrome c was found in PG490 and LPS- cotreated U87 cell. Conclusion: Taken together, combination of PG490 and LPS appears to be a potent inducer of apoptosis in astrogliaoma cells, and might have some benefit in the treatment of glioma patients.

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