Anti-CD3 antibody induces IL-10-producing CD4+CD25+ regulatory T cells, which suppress T cell response in Rheumatoid arthritis patients
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
BACKGROUND: Regulatory T cells (Tregs) have been investigated intensively for some decades. These cells regulate the immune system, prevent overactivated immune responses and can be used therapeutically. For rheumatoid arthritis (RA), understanding the functions and status of Tregs is an important step for understanding immune regulation in this autoimmune disease.0aMETHODS: We investigated the percentages, phenotypes and suppressive functions of CD4RESULTS: The percentages were higher in the patients (n25oing inflammation ineffectively. It might be possible to apply IL-10 to induce the proliferation of IL-10-producing Tregs as therapy for RA
Abstract
BACKGROUND: Regulatory T cells (Tregs) have been investigated intensively for some decades. These cells regulate the immune system, prevent overactivated immune responses and can be used therapeutically. For rheumatoid arthritis (RA), understanding the functions and status of Tregs is an important step for understanding immune regulation in this autoimmune disease.0aMETHODS: We investigated the percentages, phenotypes and suppressive functions of CD4RESULTS: The percentages were higher in the patients (n25oing inflammation ineffectively. It might be possible to apply IL-10 to induce the proliferation of IL-10-producing Tregs as therapy for RA