MicroRNAs in Human Diseases: From Autoimmune Diseases to Skin, Psychiatric and Neurodegenerative Diseases
1
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
MicroRNAs (miRNAs) are small noncoding RNA molecules that negatively regulate gene expression via degradation or translational repression of their target messenger RNAs (mRNAs). Recent studies have clearly demonstrated that miRNAs play critical roles in several biologic processes, including cell cycle, differentiation,cell development, cell growth, and apoptosis and that miRNAs are highly expressed in regulatory T (Treg)cells and a wide range of miRNAs are involved in the regulation of immunity and in the prevention of autoimmunity. It has been increasingly reported that miRNAs are associated with various human diseases like autoimmune disease, skin disease, neurological disease and psychiatric disease. Recently, the identification of mi-RNAs in skin has added a new dimension in the regulatory network and attracted significant interest in this novel layer of gene regulation. Although miRNA research in the field of dermatology is still relatively new,miRNAs have been the subject of much dermatological interest in skin morphogenesis and in regulating angiogenesis. In addition, miRNAs are moving rapidly center stage as key regulators of neuronal development and function in addition to important contributions to neurodegenerative disorder. Moreover, there is now compelling evidence that dysregulation of miRNA networks is implicated in the development and onset of human neruodegenerative diseases, such as Alzheimer’s disease, Parkinson's disease, Huntington’s disease, Tourette’s syndrome,Down syndrome, depression and schizophrenia. In this review,I briefly summarize the current studies about the roles of miRNAs in various autoimmune diseases, skin diseases,psychoneurological disorders and mental stress.
Abstract
MicroRNAs (miRNAs) are small noncoding RNA molecules that negatively regulate gene expression via degradation or translational repression of their target messenger RNAs (mRNAs). Recent studies have clearly demonstrated that miRNAs play critical roles in several biologic processes, including cell cycle, differentiation,cell development, cell growth, and apoptosis and that miRNAs are highly expressed in regulatory T (Treg)cells and a wide range of miRNAs are involved in the regulation of immunity and in the prevention of autoimmunity. It has been increasingly reported that miRNAs are associated with various human diseases like autoimmune disease, skin disease, neurological disease and psychiatric disease. Recently, the identification of mi-RNAs in skin has added a new dimension in the regulatory network and attracted significant interest in this novel layer of gene regulation. Although miRNA research in the field of dermatology is still relatively new,miRNAs have been the subject of much dermatological interest in skin morphogenesis and in regulating angiogenesis. In addition, miRNAs are moving rapidly center stage as key regulators of neuronal development and function in addition to important contributions to neurodegenerative disorder. Moreover, there is now compelling evidence that dysregulation of miRNA networks is implicated in the development and onset of human neruodegenerative diseases, such as Alzheimer’s disease, Parkinson's disease, Huntington’s disease, Tourette’s syndrome,Down syndrome, depression and schizophrenia. In this review,I briefly summarize the current studies about the roles of miRNAs in various autoimmune diseases, skin diseases,psychoneurological disorders and mental stress.
참고문헌 (112)
- Lee RC, "The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14", Cell, 75, pp.843~854 (1993)
- Wightman B, "Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans", Cell, 75, pp.855~862 (1993)
- O'Connell RM, "Physiological and pathological roles of microRNAs in the immune system", Nat Rev Immunol, 10, pp.111~122 (2010)
- Bartel DP, "MicroRNAs: Genomics, biogenesis, mechanims, and funtion", Cell, 116, pp.281~297 (2004)
- Tili E, "Expression and function of microRNAs in immune cells during normal or disease state", Int J Med, 5, pp.73~79 (2008)
- Guo H, "Mammalian microRNAs predominantly act to decrease target mRNA levels", Nature, 466, pp.835~840 (2010)
- Perera RJ, "MicroRNAs in the search for understanding human diseases", BioDrugs, 21, pp.97~104 (2007)
- Neill LA, "MicroRNAs: the fine-tuners of Toll-like receptor signalling", Nat Rev Immunol, 11, pp.163~175 (2011)
- 하대유, "The Role of MicroRNAs in Regulatory T Cells and in the Immune Response", Immune Network, 11(1), pp.11~41 (2011), 대한면역학회
- Winter J, "Many roads to maturity: microRNA biogenesis pathways and their regulation", Nat Cell Biol, 11, pp.228~234 (2009)
- Kim VN, "Biogenesis of small RNAs in animals", Nat Rev Mol Cell Biol, 10, pp.126~139 (2009)
- V. Narry Kim, "Small RNAs: Classification, Biogenesis, and Function", Molecules and Cells, 19(1), pp.1~15 (2005), 한국분자세포생물학회
- Boyd SD, "Everything you wanted to know about small RNA but were afraid to ask", Lab Invest, 88, pp.569~578 (2008)
- Rodriguez A, "Identification of mammalian microRNA host genes and transcription units", Genome Res, 14, pp.1902~1910 (2004)
- Sonkoly E, "Advances in microRNAs: implications for immunity and inflammatory diseases", J Cell Mol Med, 13, pp.24~38 (2009)
- Tomankova T, "Involvement of microRNAs in physiological and pathological processes in the lung", Respir Res, 11, pp.159~ (2010)
- Pallante P, "Deregulation of microRNA expression in follicular-cell-derived human thyroid carcinomas", Endocr Relat Cancer, 17, pp.F91~F104 (2010)
- Volinia S, "A microRNA expression signature of human solid tumors defines cancer gene targets", Proc Natl Acad Sci U S A, 103, pp.2257~2261 (2006)
- Calin GA, "MicroRNA signatures in human cancers", Nat Rev Cancer, 6, pp.857~866 (2006)
- 하대유, "MicroRNAs in Human Diseases: From Cancer to Cardiovascular Disease", Immune Network, 11(3), pp.135~154 (2011), 대한면역학회
- Belver L, "MicroRNAs prevent the generation of autoreactive antibodies", Immunity, 33, pp.713~722 (2010)
- Lu LF, "MicroRNA in the immune system, micro- RNA as an immune system", Immunology, 127, pp.291~298 (2009)
- Germain RN, "Systems biology in immunology: a computational modeling perspective", Ann Rev Immunol, 29, pp.527~585 (2011)
- Lu M, "An analysis of human microRNA and disease associations", PLoS One, 3, pp.e3420~ (2008)
- Caporali A, "Deregulation of microRNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia", Circulation, 123, pp.282~291 (2011)
- Tili E, "MicroRNAs, the immune system and rheumatic disease", Nat Clin Pract Rheumatol, 4, pp.534~541 (2008)
- De Santis G, "Altered miRNA expression in T regulatory cells in course of multiple sclerosis", J Neuroimmunol, 226, pp.165~171 (2010)
- Leeper NJ, "MicroRNA and mechanisms of impaired angiogenesis in diabetes mellitus", Circulation, 123, pp.236~238 (2011)
- Pandey AK, "MicroRNAs in diabetes: tiny players in big disease", Cell Physiol Biochem, 23, pp.221~232 (2009)
- Fulci V, "miR-223 is overexpressed in T-lymphocytes of patients affected by rheumatoid arthritis", Hum Immunol, 71, pp.206~211 (2010)
- Buckner JH, "Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases", Nat Rev Immunol, 10, pp.849~859 (2010)
- Yi R, "MicroRNA-mediated control in the skin", Cell Death Differ, 17, pp.229~235 (2010)
- Chatzikyriakidou A, "The role of microRNA-146a (miR-146a) and its target IL-1R-associated kinase (IRAK1) in psoriatic arthritis susceptibility", Scand J Immunol, 71, pp.382~385 (2010)
- Miller BH, "MicroRNA dysregulation in psychiatric disease", Brain Res, 1338, pp.89~99 (2010)
- Haramati S, "miRNA malfunction causes spinal motor neuron disease", Proc Natl Acad Sci U S A, 107, pp.13111~13116 (2010)
- Maes OC, "MicroRNA: Implications for Alzheimer disease and other human CNS disorders", Curr Genomics, 10, pp.154~168 (2009)
- Beveridge NJ, "Dysregulation of miRNA 181b in the temporal cortex in schizophrenia", Hum Mol Genet, 17, pp.1156~1168 (2008)
- Wang WX, "The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1", J Neurosci, 28, pp.1213~1223 (2008)
- Liston A, "MicroRNA in the adaptive immune system, in sickness and in health", J Clin Immunol, 30, pp.339~346 (2010)
- Schetter AJ, "Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways", Carcinogenesis, 31, pp.37~49 (2010)
- Yu Z, "microRNA 17", 20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling, 2010, pp.107, 8231~8236
- Liu C, "The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44", Nat Med, 17, pp.211~215 (2011)
- Navarro A, "MicroRNA expression profiling in classic Hodgkin lymphoma", Blood, 111, pp.2825~2832 (2008)
- Small EM, "Pervasive roles of microRNAs in cardiovascular biology", Nature, 469, pp.336~342 (2011)
- Wang GK, "Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans", Eur Heart J, 31, pp.659~666 (2010)
- Contu R, "Circulating micro-RNAs as potential biomarkers of coronary artery disease: a promise to be fulfilled", Circ Res, 107, pp.573~574 (2010)
- Qian L, "miR-24 inhibits apoptosis and represses Bim in mouse cardiomyocytes", J Exp Med, 208, pp.549~560 (2011)
- Tan Z, "Allele-specific targeting of microRNAs to HLA-G and risk of asthma", Am J Hum Genet, 81, pp.829~834 (2007)
- Mattes J, "Antagonism of microRNA-126 suppresses the effector function of TH2 cells and the development of allergic airways disease", Proc Natl Acad Sci U S A, 106, pp.18704~18709 (2009)
- Polikepahad S, "Proinflammatory role for let-7 microRNAS in experimental asthma", J Biol Chem, 285, pp.30139~30149 (2010)
- Li Y, "MicroRNA expression and virulence in pandemic influenza virus-infected mice", J Virol, 84, pp.3023~3032 (2010)
- Witwer KW, "MicroRNA regulation of IFN-beta protein expression: rapid and sensitive modulation of the innate immune response", J Immunol, 184, pp.2369~2376 (2010)
- Belair C, "Helicobacter pylori and gastric cancer: possible role of microRNAs in this intimate relationship", Clin Microbiol Infect, 15, pp.806~812 (2009)
- Liu X, "Systematic identification of microRNA and messenger RNA profiles in hepatitis C virus- infected human hepatoma cells", Virology, 398, pp.57~67 (2010)
- Zhang GL, "Suppression of hepatitis B virus replication by microRNA- 199a-3p and microRNA-210", Antiviral Res, 88, pp.169~175 (2010)
- Liston A, "Dicer-dependent microRNA pathway safeguards regulatory T cell function", J Exp Med, 205, pp.1993~2004 (2008)
- Zhou X, "Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity", J Exp Med, 205, pp.1983~1991 (2008)
- Cobb BS, "A role for Dicer in immune regulation", J Exp Med, 203, pp.2519~2527 (2006)
- 하대유, "Regulatory T Cell Therapy for Autoimmune Disease", Immune Network, 8(4), pp.107~123 (2008), 대한면역학회
- Pauley KM, "MicroRNA in autoimmunity and autoimmune diseases", J Autoimmun, 32, pp.189~194 (2009)
- Dalal SR, "The role of MicroRNA in inflammatory bowel disease", Gastroenterol Hepatol (N Y), 6, pp.714~722 (2010)
- Song L, "MicroRNAs and cell differentiation in mammalian development", Birth Defects Res C Embryo Today, 78, pp.140~149 (2006)
- Sand M, "MicroRNAs and the skin: tiny players in the body's largest organ", J Dermatol Sci, 53, pp.169~175 (2009)
- Nelson PT, "MicroRNAs (miRNAs) in neurodegenerative diseases", Brain Pathol, 18, pp.130~138 (2008)
- Martino S, "MicroRNA implications across neurodevelopment and neuropathology", J Biomed Biotechnol, pp.13~ (2009)
- Hunsberger JG, "MicroRNAs in mental health: from biological underpinnings to potential therapies", Neuromolecular Med, 11, pp.173~182 (2009)
- 김종필, "A microRNA feedback circuit in midbrain dopamine neurons", SCIENCE, 317(5842), pp.1220~1224, AMER ASSOC ADVANCEMENT SCIENCE
- Packer AN, "The bifunctional microRNA miR-9", miR-9* regulates REST and CoREST and is downregulated in Huntington's disease, 2008, pp.28, 14341~14346
- Garofalo M, "MicroRNAs in diseases and drug response", Curr Opin Pharmacol, 8, pp.661~667 (2008)
- Chang S, "Small regulatory RNAs in neurodevelopmental disorders", Hum Mol Genet, 18, pp.R18~R26 (2009)
- Abelson JF, "Sequence variants in SLITRK1 are associated with Tourette's syndrome", Science, 310, pp.317~320 (2005)
- Kuhn DE, "Human chromosome 21-derived miRNAs are overexpressed in down syndrome brains and hearts", Biochem Biophys Res Commun, 370, pp.473~477 (2008)
- Perkins DO, "microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder", Genome Biol, 8, pp.R27~ (2007)
- Beveridge NJ, "Schizophrenia is associated with an increase in cortical microRNA biogenesis", Mol Psychiatry, 15, pp.1176~1189 (2010)
- Li J, "Altered microRNA expression profile with miR-146a upregulation in CD4+ T cells from patients with rheumatoid arthritis", Arthritis Res Ther, 12, pp.R81~ (2010)
- Sheedy FJ, "Adding fuel to fire: microRNAs as a new class of mediators of inflammation", Ann Rheum Dis, 67(3), pp.iii50~iii55 (2008)
- Pauley KM, "Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients", Arthritis Res Ther, 10, pp.R101~ (2008)
- Nakasa T, "Expression of microRNA-146 in rheumatoid arthritis synovial tissue", Arthritis Rheum, 58, pp.1284~1292 (2008)
- Stanczyk J, "Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis", Arthritis Rheum, 58, pp.1001~1009 (2008)
- Luo X, "Evidence for microRNAmediated regulation in rheumatic diseases", Ann Rheum Dis, 69(1), pp.i30~i36 (2010)
- Chan EK, "Contrast in aberrant microRNA expression in systemic lupus erythematosus and rheumatoid arthritis: is microRNA-146 all we need", Arthritis Rheum, 60, pp.912~915 (2009)
- Dai Y, "Microarray analysis of microRNA expression in peripheral blood cells of systemic lupus erythematosus patients", Lupus, 16, pp.939~946 (2007)
- Divekar AA, "Dicer insufficiency and microRNA-155 overexpression in lupus regulatory T cells: an apparent paradox in the setting of an inflammatory milieu", J Immunol, 186, pp.924~930 (2011)
- Mellor AL, "Physiologic control of the functional status of Foxp3+ regulatory T cells", J Immunol, 186, pp.4535~4540 (2011)
- Gauthier BR, "MicroRNAs: 'ribo-regulators' of glucose homeostasis", Nat Med, 12, pp.36~38 (2006)
- Hezova R, "MicroRNA-342, microRNA-191 and microRNA-510 are differentially expressed in T regulatory cells of type 1 diabetic patients", Cell Immunol, 260, pp.70~74 (2010)
- Keller A, "Multiple sclerosis: microRNA expression profiles accurately differentiate patients with relapsing-remitting disease from healthy controls", PLoS One, 4, pp.e7440~ (2009)
- Du C, "MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis", Nat Immunol, 10, pp.1252~1259 (2009)
- Schrempf W, "Glatiramer acetate: mechanisms of action in multiple sclerosis", Autoimmun Rev, 6, pp.469~475 (2007)
- Lu LF, "Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein", Immunity, 30, pp.80~91 (2009)
- Miller RL, "Environmental epigenetics and asthma: current concepts and call for studies", Am J Respir Crit Care Med, 177, pp.567~573 (2008)
- Lu TX, "MicroRNA-21 is upregulated in allergic airway inflammation and regulates IL-12p35 expression", J Immunol, 182, pp.4994~5002 (2009)
- Sonkoly E, "MicroRNAs: novel regulators involved in the pathogenesis of psoriasis", PLoS One, 2, pp.e610~ (2007)
- Sonkoly E, "MicroRNAs: novel regulators in skin inflammation", Clin Exp Dermatol, 33, pp.312~315 (2008)
- Wu F, "Peripheral blood microRNAs distinguish active ulcerative colitis and Crohn's disease", Inflamm Bowel Dis, 17, pp.241~250 (2011)
- Wu F, "MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2 alpha", Gastroenterology, 135, pp.1624~1635 (2008)
- Wu F, "Identification of microRNAs associated with ileal and colonic Crohn's disease", Inflamm Bowel Dis, 16, pp.1729~1738 (2010)
- Saito Y, "The role of microRNAs in gastrointestinal cancers", J Gastroenterol, 44(19), pp.18~22 (2009)
- Sen CK, "Micromanaging vascular biology: tiny microRNAs play big band", J Vasc Res, 46, pp.527~540 (2009)
- Liu J, "MicroRNAs and Epithelial Immunity", Int Rev Immunol, 28, pp.139~154 (2009)
- Sonkoly E, "MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte-associated antigen 4", J Allergy Clin Immunol, 126, pp.581~589 (2010)
- Roshan R, "MicroRNAs: novel therapeutic targets in neurodegenerative diseases", Drug Discov Today, 14, pp.1123~1129 (2009)
- Toyota M, "Epigenetic silencing of micro- RNA- 34b", c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer, 2008, pp.68, 123~132
- Hébert SS, "Alterations of the microRNA network cause neurodegenerative disease", Trends Neurosci, 32, pp.199~206 (2009)
- Provost P, "MicroRNAs as a molecular basis for mental retardation, Alzheimer's and prion diseases", Brain Res, 1338, pp.58~66 (2010)
- Hébert SS, "Loss of microRNA cluster miR- 29a", b-1 in sporadic Alzheimer's disease correlates with increased BACE1, Proc Natl Acad Sci U S A, pp.2008, 105[DOI]
- Rovelet-Lecrux A, "APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy", Nat Genet, 38, pp.24~26 (2006)
- Burmistrova OA, "MicroRNA in schizophrenia: genetic and expression analysis of miR-130b (22q11)", Biochemistry (Mosc), 72, pp.578~582 (2007)
- Hansen T, "Brain expressed microRNAs implicated in schizophrenia etiology", PLoS One, 2, pp.e873~ (2007)
- Guo AY, "A novel microRNA and transcription factor mediated regulatory network in schizophrenia", BMC Syst Biol, 4, pp.10~ (2010)
- Meerson A, "Changes in brain microRNAs contribute to cholinergic stress reactions", J Mol Neurosci, 40, pp.47~55 (2010)
- Radom-Aizik S, "Evidence for microRNA involvement in exercise- associated neutrophil gene expression changes", J Appl Physiol, 109, pp.252~261 (2010)
