Encapsulated Islet Transplantation: Strategies and Clinical Trials
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Encapsulation of tissue has been an area of intense research with a myriad number of therapeutic applications as diverse as cancer, tissue regeneration, and diabetes. In the case of diabetes, transplantation of pancreatic islets of Langerhans containing insulin-producing beta cells has shown promise toward a cure. However, anti-rejection therapy that is needed to sustain the transplanted tissue has numerous adverse effects, and the islets might still be damaged by immune processes. Furthermore, the profound scarcity of healthy human donor organs restricts the availability of islets for transplant. Islet encapsulation allows the protection of this tissue without the use of toxic medications, while also expanding the donor pool to include animal sources. Before the widespread application of this therapy, there are still issues that need to be resolved. There are many materials that can be used, differing shapes and sizes of capsules, and varied sources of islets to name a few variables that need to be considered. In this review, the current options for capsule generation, past animal and human studies, and future directions in this area of research are discussed.
Abstract
Encapsulation of tissue has been an area of intense research with a myriad number of therapeutic applications as diverse as cancer, tissue regeneration, and diabetes. In the case of diabetes, transplantation of pancreatic islets of Langerhans containing insulin-producing beta cells has shown promise toward a cure. However, anti-rejection therapy that is needed to sustain the transplanted tissue has numerous adverse effects, and the islets might still be damaged by immune processes. Furthermore, the profound scarcity of healthy human donor organs restricts the availability of islets for transplant. Islet encapsulation allows the protection of this tissue without the use of toxic medications, while also expanding the donor pool to include animal sources. Before the widespread application of this therapy, there are still issues that need to be resolved. There are many materials that can be used, differing shapes and sizes of capsules, and varied sources of islets to name a few variables that need to be considered. In this review, the current options for capsule generation, past animal and human studies, and future directions in this area of research are discussed.
참고문헌 (38)
- Gabardi, S, "Understanding risk evaluation and mitigation strategies in organ transplantation", Pharmacotherapy, 31, pp.714~722 (2011)
- Alves, M. G., "Impact of diabetes in blood-testis and blood-brain barriers: resemblances and differences", Curr. Diabetes Rev, 8, pp.401~412 (2012)
- Salmons, B., "Therapeutic application of cell microencapsulation in cancer", Adv. Exp. Med. Biol, 670, pp.92~103 (2010)
- Thanos, C. G., "Microencapsulated choroid plexus epithelial cell transplants for repair of the brain", Adv. Exp. Med. Biol, 670, pp.80~91 (2010)
- Lee, K. Y., "Hydrogels for tissue engineering", Chem. Rev, 101, pp.1869~1879 (2001)
- Nicodemus, G. D., "Cell encapsulation in biodegradable hydrogels for tissue engineering applications", Tissue Eng. Part B Rev, 14, pp.149~165 (2008)
- Peppas, N. A., "Hydrogels in biology and medicine: from molecular principles to bionanotechnology", Adv. Mater, 18, pp.1345~1360 (2006)
- Zimmermann, H., "Alginate-based encapsulation of cells: past, present, and future", Curr. Diab. Rep, 7, pp.314~320 (2007)
- Safley, S. A., "Biocompatibility and immune acceptance of adult porcine islets transplanted intraperitoneally in diabetic NOD mice in calcium alginate poly-L-lysine microcapsules versus barium alginate microcapsules without poly-L-lysine", J. Diabetes Sci. Technol, 2, pp.760~767 (2008)
- Tuch, B. E., "Safety and viability of microencapsulated human islets transplanted into diabetic humans", Diabetes Care, 32, pp.1887~1889 (2009)
- Elliott, R. B., "Live encapsulated porcine islets from a type 1 diabetic patient 9.5 yr after xenotransplantation", Xenotransplantation, 14, pp.157~161 (2007)
- Tarantal, A. F., "Real-time bioluminescence imaging of macroencapsulated fibroblasts reveals allograft protection in rhesus monkeys (Macaca mulatta)", Transplantation, 88, pp.38~41 (2009)
- Cornolti, R., "Effect of micro- and macroencapsulation on oxygen consumption by pancreatic islets", Cell Transplant, 18, pp.195~201 (2009)
- Lembert, N., "Encapsulation of islets in rough surface, hydroxymethylated polysulfone capillaries stimulates VEGF release and promotes vascularization after transplantation", Cell Transplant, 14, pp.97~108 (2005)
- Vaithilingam, V., "Islet transplantation and encapsulation: an update on recent developments", Rev. Diabet. Stud, 8, pp.51~67 (2011)
- Lim, F., "Microencapsulated islets as bioartificial endocrine pancreas", Science, 210, pp.908~910 (1980)
- Souza, Y. E., "Islet transplantation in rodents. Do encapsulated islets really work?", Arq. Gastroenterol, 48, pp.146~152 (2011)
- Suzuki, K., "Function and survival of macroencapsulated syngeneic islets transplanted into streptozocin-diabetic mice", Transplantation, 66, pp.21~28 (1998)
- Duvivier-Kali, V. F., "Survival of microencapsulated adult pig islets in mice in spite of an antibody response", Am. J. Transplant, 4, pp.1991~2000 (2004)
- Soon-Shiong, P., "Long-term reversal of diabetes by the injection of immunoprotected islets", Proc. Natl. Acad. Sci. U. S. A, 90, pp.5843~5847 (1993)
- Dufrane, D., "Six-month survival of microencapsulated pig islets and alginate biocompatibility in primates: proof of concept", Transplantation, 81, pp.1345~1353 (2006)
- Dufrane, D., "Alginate macroencapsulation of pig islets allows correction of streptozotocin- induced diabetes in primates up to 6 months without immunosuppression", Transplantation, 90, pp.1054~1062 (2010)
- Elliott, R. B., "Intraperitoneal alginate-encapsulated neonatal porcine islets in a placebo-controlled study with 16 diabetic cynomolgus primates", Transplant. Proc, 37, pp.3505~3508 (2005)
- Soon-Shiong, P., "Insulin independence in a type 1 diabetic patient after encapsulated islet transplantation", Lancet, 343, pp.950~951 (1994)
- Valdes-Gonzalez, R. A., "Xenotransplantation of porcine neonatal islets of Langerhans and Sertoli cells: a 4-year study", Eur. J. Endocrinol, 153, pp.419~427 (2005)
- Valdes-Gonzalez, R., "Long-term follow-up of patients with type 1 diabetes transplanted with neonatal pig islets", Clin. Exp. Immunol, 162, pp.537~542 (2010)
- Elliot, R. B., "Living Cell Technologies" (2011), Ltd, Prague
- Chhabra, P., "Current status of immunomodulatory and cellular therapies in preclinical and clinical islet transplantation", J. Ttransplant, 2011, pp.637692~ (2011)
- Gao, Q., "TLR4 mediates early graft failure after intraportal islet transplantation", Am. J. Transplant, 10, pp.1588~1596 (2010)
- Su, J., "Anti-inflammatory peptide-functionalized hydrogels for insulin-secreting cell encapsulation", Biomaterials, 31, pp.308~314 (2010)
- Bunger, C. M., "Deletion of the tissue response against alginate- pll capsules by temporary release of co-encapsulated steroids", Biomaterials, 26, pp.2353~2360 (2005)
- Dionne, K. E., "Effect of hypoxia on insulin secretion by isolated rat and canine islets of Langerhans", Diabetes, 42, pp.12~21 (1993)
- Kuhtreiber, W. M., "Relationship between insulin secretion and oxygen tension in hybrid diffusion chambers", ASAIO J, 39, pp.M247~M251 (1993)
- De Vos, P., "Why do microencapsulated islet grafts fail in the absence of fibrotic overgrowth?", Diabetes, 48, pp.1381~1388 (1999)
- Pedraza, E., "Preventing hypoxia-induced cell death in beta cells and islets via hydrolytically activated, oxygen-generating biomaterials", Proc. Natl. Acad. Sci. U. S. A, 109, pp.4245~4250 (2012)
- Fritschy, W. M., "Glucose tolerance and plasma insulin response to intravenous glucose infusion and test meal in rats with microencapsulated islet allografts", Diabetologia, 34, pp.542~547 (1991)
- Khanna, O., "Synthesis of multilayered alginate microcapsules for the sustained release of fibroblast growth factor-1", J. Biomed. Mater. Res. A, 95, pp.632~640 (2010)
- Ludwig, B., "Agonist of growth hormone-releasing hormone as a potential effector for survival and proliferation of pancreatic islets", Proc. Natl. Acad. Sci. U. S. A, 107, pp.12623~12628 (2010)