Insulin Resistance and Serum Levels of Interleukin-17 and Interleukin-18 in Normal Pregnancy
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
We performed this study to evaluate the role of Interleukin-17 (IL-17) and Interleukin-18 (IL-18) in insulin resistance during normal pregnancy. This descriptive cross sectional study was carried out on 97 healthy pregnant women including 32, 25, and 40 individuals in the first, second, and third trimesters, respectively, and on 28 healthy non pregnant women between the autumn of 2012 and the spring of 2013. We analyzed the serum concentrations of IL-17 and IL-18 by using the enzyme linked immunosorbent assay (ELISA). Insulin resistance was measured by homeostasis model assessment of insulin resistance equation. No significant differences between the demographic data of the pregnant and non pregnant groups were observed. Insulin resistant in pregnant women was significantly higher than the controls (p=0.006). Serum IL-17 concentration was significantly different in non pregnant women and pregnant women in all gestational ages (p＜0.05). Serum IL-18 level was significantly lower in subjects with first, second, and third trimesters of pregnancy in compared to non pregnant women (p＜0.05). No significant correlations were found between serum IL-17 and IL-18 levels with insulin resistance (r=0.08, p=0.34 vs. r=0.01, p=0.91, respectively). Our data suggested that IL-17 and IL-18 do not appear to attribute greatly to pregnancy deduced insulin resistance during normal pregnancy.
Abstract
We performed this study to evaluate the role of Interleukin-17 (IL-17) and Interleukin-18 (IL-18) in insulin resistance during normal pregnancy. This descriptive cross sectional study was carried out on 97 healthy pregnant women including 32, 25, and 40 individuals in the first, second, and third trimesters, respectively, and on 28 healthy non pregnant women between the autumn of 2012 and the spring of 2013. We analyzed the serum concentrations of IL-17 and IL-18 by using the enzyme linked immunosorbent assay (ELISA). Insulin resistance was measured by homeostasis model assessment of insulin resistance equation. No significant differences between the demographic data of the pregnant and non pregnant groups were observed. Insulin resistant in pregnant women was significantly higher than the controls (p=0.006). Serum IL-17 concentration was significantly different in non pregnant women and pregnant women in all gestational ages (p＜0.05). Serum IL-18 level was significantly lower in subjects with first, second, and third trimesters of pregnancy in compared to non pregnant women (p＜0.05). No significant correlations were found between serum IL-17 and IL-18 levels with insulin resistance (r=0.08, p=0.34 vs. r=0.01, p=0.91, respectively). Our data suggested that IL-17 and IL-18 do not appear to attribute greatly to pregnancy deduced insulin resistance during normal pregnancy.
참고문헌 (31)
- Hadden, D. R., "Normal and abnormal maternal metabolism during pregnancy", Semin. Fetal Neonatal Med, 14, pp.66~71 (2009)
- Baranyi, E., "Diabetes and pregnancy", Orv Hetil, 152, pp.1635~1640 (2011)
- Kirwan, J. P, "TNF-alpha is a predictor of insulin resistance in human pregnancy", Diabetes, 51, pp.2207~2213 (2002)
- Gwozdziewiczova, S., "Tumor necrosis factor alfa (TNFalpha) and insulin resistance", Cesk Fysiol, 53, pp.167~175 (2004)
- Senn, J. J., "Interleukin-6 induces cellular insulin resistance in hepatocytes", Diabetes, 51(12), pp.3391~3399 (2002)
- Zinman, B., "Circulating tumor necrosis factor-alpha concentrations in a native Canadian population with high rates of type 2 diabetes mellitus", J. Clin. Endocrinol. Metab, 84, pp.272~278 (1999)
- Ahmed, M, "IL-17 in obesity and adipogenesis", Cytokine Growth Factor Rev, 21, pp.449~453 (2010)
- Roland, L., "Plasma interleukin-18 (IL-18) levels are correlated with antioxidant vitamin coenzyme Q(10) in preeclampsia", Acta Obstet. Gynecol. Scand, 89, pp.360~366 (2010)
- Shearman, A. M., "Association between estrogen receptor alpha gene variation and cardiovascular disease", JAMA, 290, pp.2263~2270 (2003)
- Matthews, D. R., "Homeostasis model assessment : insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man", Diabetologia, 28, pp.412~419 (1985)
- Jahromi, A. S., "Association of insulin resistance with serum interleukin-6 and TNF-alpha levels during normal pregnancy", Biomark Insights, 6, pp.1~6 (2011)
- Jahromi, A. S, "Insulin resistance and interleukin-1β during normal pregnancy", Asian J. Biochem, 6, pp.366~372
- Clapp, J. F., "Effects of Diet and Exercise on Insulin Resistance during Pregnancy", Metab Syndr Relat Disord, 4, pp.84~90 (2006)
- Manley, S. E, "Preanalytical, analytical, and computational factors affect homeostasis model assessment estimates", Diabetes Care, 31, pp.1877~1883 (2008)
- Harrington, L. E., "Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages", Nat. Immunol, 6, pp.1123~1132 (2005)
- Park, H., "A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17", Nat. Immunol, 6, pp.1133~1141 (2005)
- Xu, S., "Interleukin-17 and its expanding biological functions", Cell Mol. Immunol, 7, pp.164~174 (2010)
- Louten, J., "Development and function of TH17 cells in health and disease", J. Allergy Clin. Immunol, 123, pp.1004~1011 (2009)
- Peck, A., "Breaking old paradigms: Th17 cells in autoimmune arthritis", Clin. Immunol, 132, pp.295~304 (2009)
- Sallusto, F., "Human Th17 cells in infection and autoimmunity", Microbes Infect, 11, pp.620~624 (2009)
- Marzi, M, "Characterization of type 1 and type 2 cytokine production profile in physiologic and pathologic human pregnancy", Clin. Exp. Immunol, 106, pp.127~133 (1996)
- Saito, S., "Th1", Th2, Am. J. Reprod. Immunol, pp.2010, 63[DOI]
- Saito, S., "Clinical implication of recent advances in our understanding of IL-17 and reproductive immunology", Expert Rev. Clin. Immunol, 7, pp.649~657 (2011)
- Okamura, H, "Regulation of interferon-gamma production by IL-12 and IL-18", Curr. Opin. Immunol, 10, pp.259~264 (1998)
- Nakanishi, K, "Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu", Cytokine Growth Factor Rev, 12, pp.53~72 (2001)
- Ekelund, C. K., "Interleukin-18 and interleukin-12 in maternal serum and spontaneous preterm delivery", J. Reprod. Immunol, 77, pp.179~185 (2008)
- Sakai, M., "The ratio of interleukin (IL)-18 to IL-12 secreted by peripheral blood mononuclear cells is increased in normal pregnant subjects and decreased in pre-eclamptic patients", J. Reprod. Immunol, 61, pp.133~143 (2004)
- Jagannathan-Bogdan, M., "Elevated proinflammatory cytokine production by a skewed T cell compartment requires monocytes and promotes inflammation in type 2 diabetes", J. Immunol, 186, pp.1162~1172 (2011)
- Esposito, K, "Weight loss reduces interleukin-18 levels in obese women", J. Clin. Endocrinol. Metab, 87, pp.3864~3866 (2002)
- Gaffen, S. L., "Structure and signalling in the IL-17 receptor family", Nat. Rev. Immunol, 9, pp.556~567 (2009)
- Escobar-Morreale, H. F., "Serum interleukin-18 concentrations are increased in the polycystic ovary syndrome: relationship to insulin resistance and to obesity", J. Clin. Endocrinol. Metab, 89, pp.806~811 (2004)