Development of New Preventive and Therapeutic Vaccines for Tuberculosis
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Tuberculosis (TB) is a contagious disease that has been responsible for the death of one billion people in the last 200 years. Until now, the only vaccine approved for the prevention of TB is Bacillus Calmette-Guérin (BCG), which is prepared by attenuating Mycobacterium bovis. However, one of the limitations of BCG is that its preventive effect against pulmonary TB varies from person to person. Therefore, there arises a need for a new TB vaccine to replace or supplement BCG. In this review, we have summarized the findings of current clinical trials on preventive and therapeutic TB vaccine candidates. In addition, we have discussed a novel vaccination approach using the cell-based vaccine presenting early secretory antigenic target-6 (ESAT-6), which is a potent immunogenic antigen. The role of ESAT-6 in hosts has also been described.
Abstract
Tuberculosis (TB) is a contagious disease that has been responsible for the death of one billion people in the last 200 years. Until now, the only vaccine approved for the prevention of TB is Bacillus Calmette-Guérin (BCG), which is prepared by attenuating Mycobacterium bovis. However, one of the limitations of BCG is that its preventive effect against pulmonary TB varies from person to person. Therefore, there arises a need for a new TB vaccine to replace or supplement BCG. In this review, we have summarized the findings of current clinical trials on preventive and therapeutic TB vaccine candidates. In addition, we have discussed a novel vaccination approach using the cell-based vaccine presenting early secretory antigenic target-6 (ESAT-6), which is a potent immunogenic antigen. The role of ESAT-6 in hosts has also been described.
참고문헌 (85)
- Paulson T, "Epidemiology: a mortal foe", Nature, 502, pp.S2~S3 (2013)[DOI]
- Global Tuberculosis Report 2016, "World Health Organization", World Health Organization, ~ (2016)
- Havlir DV, "Opportunities and challenges for HIV care in overlapping HIV and TB epidemics", JAMA, 300, pp.423~430 (2008)[DOI]
- Lonnroth K, "Tuberculosis control and elimination 2010-50: cure, care, and social development", Lancet, 375, pp.1814~1829 (2010)[DOI]
- Rehm J, "The association between alcohol use, alcohol use disorders and tuberculosis (TB). A systematic review", BMC Public Health, 9, pp.450~ (2009)[DOI]
- Vynnycky E, "The natural history of tuberculosis: the implications of age-dependent risks of disease and the role of reinfection", Epidemiol Infect, 119, pp.183~201 (1997)[DOI]
- Mazurek GH, "Comparison of a whole-blood interferon gamma assay with tuberculin skin testing for detecting latent Mycobacterium tuberculosis infection", JAMA, 286, pp.1740~1747 (2001)[DOI]
- Kolloli A, "Host-directed therapeutic strategies for tuberculosis", Front Med (Lausanne), 4, pp.171~ (2017)[DOI]
- Pontali E, "Bedaquiline and multidrug-resistant tuberculosis: a systematic and critical analysis of the evidence", Eur Respir J, 47, pp.394~402 (2016)[DOI]
- Agyeman AA, "Efficacy and safety profile of linezolid in the treatment of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis: a systematic review and meta-analysis", Ann Clin Microbiol Antimicrob, 15, pp.41~ (2016)[DOI]
- Bruns H, "Abelson tyrosine kinase controls phagosomal acidification required for killing of Mycobacterium tuberculosis in human macrophages", J Immunol, 189, pp.4069~4078 (2012)[DOI]
- Napier RJ, "Low doses of imatinib induce myelopoiesis and enhance host anti-microbial immunity", PLoS Pathog, 11, pp.e1004770~ (2015)[DOI]
- Napier RJ, "Imatinib-sensitive tyrosine kinases regulate mycobacterial pathogenesis and represent therapeutic targets against tuberculosis", Cell Host Microbe, 10, pp.475~485 (2011)[DOI]
- Singhal A, "Metformin as adjunct antituberculosis therapy", Sci Transl Med, 6, pp.263ra159~ (2014)[DOI]
- Verreck FA, "Variable BCG efficacy in rhesus populations: pulmonary BCG provides protection where standard intra-dermal vaccination fails", Tuberculosis (Edinb), 104, pp.46~57 (2017)[DOI]
- Brewer TF, "Preventing tuberculosis with Bacillus Calmette-Guerin vaccine: a meta-analysis of the literature", Clin Infect Dis, 31, pp.S64~S67 (2000)[DOI]
- Mangtani P, "Protection by BCG vaccine against tuberculosis: a systematic review of randomized controlled trials", Clin Infect Dis, 58, pp.470~480 (2014)[DOI]
- Grode L, "Safety and immunogenicity of the recombinant BCG vaccine VPM1002 in a phase 1 open-label randomized clinical trial", Vaccine, 31, pp.1340~1348 (2013)[DOI]
- Nieuwenhuizen NE, "The recombinant Bacille Calmette-Guerin vaccine VPM1002: ready for clinical efficacy testing", Front Immunol, 8, pp.1147~ (2017)[DOI]
- Geoffroy C, "Purification, characterization, and toxicity of the sulfhydryl-activated hemolysin listeriolysin O from Listeria monocytogenes", Infect Immun, 55, pp.1641~1646 (1987)
- Grode L, "Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis Bacille Calmette-Guerin mutants that secrete listeriolysin", J Clin Invest, 115, pp.2472~2479 (2005)[DOI]
- Decatur AL, "A PEST-like sequence in listeriolysin O essential for Listeria monocytogenes pathogenicity", Science, 290, pp.992~995 (2000)[DOI]
- Moliva JI, "Prospects in Mycobacterium bovis Bacille Calmette et Guerin (BCG) vaccine diversity and delivery: why does BCG fail to protect against tuberculosis?", Vaccine, 33, pp.5035~5041 (2015)[DOI]
- Fletcher HA, "TB vaccine development and the end TB strategy: importance and current status", Trans R Soc Trop Med Hyg, 110, pp.212~218 (2016)[DOI]
- Loxton AG, "Safety and immunogenicity of the recombinant Mycobacterium bovis BCG vaccine VPM1002 in HIV-unexposed newborn infants in South Africa", Clin Vaccine Immunol, 24, pp.e00439~16 (2017)
- Fletcher HA, "Sleeping beauty and the story of the Bacille Calmette-Guerin vaccine", MBio, 7, pp.e01370~16 (2016)
- Kaufmann SH, "Progress in tuberculosis vaccine development and host-directed therapies--a state of the art review", Lancet Respir Med, 2, pp.301~320 (2014)[DOI]
- Lee JS, "Mutation in the transcriptional regulator PhoP contributes to avirulence of Mycobacterium tuberculosis H37Ra strain", Cell Host Microbe, 3, pp.97~103 (2008)[DOI]
- Whole Mycobacteria Cell Vaccines for Tuberculosis Summary Group, "Developing whole mycobacteria cell vaccines for tuberculosis: Workshop proceedings, Max Planck Institute for Infection Biology, Berlin, Germany, July 9, 2014", Vaccine, 33, pp.3047~3055 (2015)[DOI]
- Arbues A, "Construction, characterization and preclinical evaluation of MTBVAC, the first live-attenuated M. tuberculosis-based vaccine to enter clinical trials", Vaccine, 31, pp.4867~4873 (2013)[DOI]
- Mearns H, "H1:IC31 vaccination is safe and induces long-lived TNF-alpha+IL-2+CD4 T cell responses in M. tuberculosis infected and uninfected adolescents: a randomized trial", Vaccine, 35, pp.132~141 (2017)[DOI]
- Reither K, "Safety and immunogenicity of H1", IC31(R), an adjuvanted TB subunit vaccine, in HIV-infected adults with CD4+ lymphocyte counts greater than 350 cells, PLoS One, pp.2014, 9[DOI]
- van Dissel JT, "A novel liposomal adjuvant system, CAF01, promotes long-lived Mycobacterium tuberculosis-specific T-cell responses in human", Vaccine, 32, pp.7098~7107 (2014)[DOI]
- Luabeya AK, "First-in-human trial of the post-exposure tuberculosis vaccine H56:IC31 in Mycobacterium tuberculosis infected and non-infected healthy adults", Vaccine, 33, pp.4130~4140 (2015)[DOI]
- Billeskov R, "The HyVac4 subunit vaccine efficiently boosts BCG-primed anti-mycobacterial protective immunity", PLoS One, 7, pp.e39909~ (2012)[DOI]
- Skeiky YA, "Non-clinical efficacy and safety of HyVac4:IC31 vaccine administered in a BCG prime-boost regimen", Vaccine, 28, pp.1084~1093 (2010)[DOI]
- Cha SB, "Pulmonary immunity and durable protection induced by the ID93", GLA-SE vaccine candidate against the hyper-virulent Korean Beijing Mycobacterium tuberculosis strain K, 2016, pp.34, 2179~2187
- Coler RN, "Therapeutic immunization against Mycobacterium tuberculosis is an effective adjunct to antibiotic treatment", J Infect Dis, 207, pp.1242~1252 (2013)[DOI]
- Dockrell HM, "Towards new TB vaccines: what are the challenges?", Pathog Dis, 74, pp.ftw016~ (2016)[DOI]
- Tameris MD, "Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial", Lancet, 381, pp.1021~1028 (2013)[DOI]
- van Zyl-Smit RN, "Safety and immunogenicity of adenovirus 35 tuberculosis vaccine candidate in adults with active or previous tuberculosis. A randomized trial", Am J Respir Crit Care Med, 195, pp.1171~1180 (2017)[DOI]
- Xing Z, "Intranasal mucosal boosting with an adenovirus-vectored vaccine markedly enhances the protection of BCG-primed guinea pigs against pulmonary tuberculosis", PLoS One, 4, pp.e5856~ (2009)[DOI]
- Smaill F, "A human type 5 adenovirus-based tuberculosis vaccine induces robust T cell responses in humans despite preexisting anti-adenovirus immunity", Sci Transl Med, 5, pp.205ra134~ (2013)[DOI]
- Mendez-Samperio P, "Global efforts in the development of vaccines for tuberculosis: requirements for improved vaccines against Mycobacterium tuberculosis", Scand J Immunol, 84, pp.204~210 (2016)[DOI]
- von Reyn CF, "Prevention of tuberculosis in Bacille Calmette-Guerin-primed, HIV-infected adults boosted with an inactivated whole-cell mycobacterial vaccine", AIDS, 24, pp.675~685 (2010)[DOI]
- Butov DA, "Phase IIb randomized trial of adjunct immunotherapy in patients with first-diagnosed tuberculosis, relapsed and multi-drug-resistant (MDR) TB", J Immune Based Ther Vaccines, 9, pp.3~ (2011)[DOI]
- Gupta A, "Protective efficacy of Mycobacterium indicus pranii against tuberculosis and underlying local lung immune responses in guinea pig model", Vaccine, 30, pp.6198~6209 (2012)[DOI]
- He L, "Flow cytometry: an efficient method for antigenicity measurement and particle characterization on an adjuvanted vaccine candidate H4-IC31 for tuberculosis", J Immunol Methods, 452, pp.39~45 (2018)[DOI]
- Neeland MR, "The lymphatic immune response induced by the adjuvant AS01: a comparison of intramuscular and subcutaneous immunization routes", J Immunol, 197, pp.2704~2714 (2016)[DOI]
- Detienne S, "Central role of CD169+ lymph node resident macrophages in the adjuvanticity of the QS-21 component of AS01", Sci Rep, 6, pp.39475~ (2016)[DOI]
- Gillard P, "Safety and immunogenicity of the M72", AS01E candidate tuberculosis vaccine in adults with tuberculosis: a phase II randomised study, 2016, pp.100, 118~127
- Rose F, "Engineering of a novel adjuvant based on lipid-polymer hybrid nanoparticles: a quality-by-design approach", J Control Release, 210, pp.48~57 (2015)[DOI]
- Velmurugan K, "Mycobacterium tuberculosis nuoG is a virulence gene that inhibits apoptosis of infected host cells", PLoS Pathog, 3, pp.e110~ (2007)[DOI]
- Gengenbacher M, "Deletion of nuoG from the vaccine candidate Mycobacterium bovis BCG deltaurec:hly improves protection against tuberculosis", MBio, 7, pp.e00679~16 (2016)
- Moguche AO, "Antigen availability shapes T cell differentiation and function during tuberculosis", Cell Host Microbe, 21, pp.695~706 (2017)[DOI]
- Brandt L, "ESAT-6 subunit vaccination against Mycobacterium tuberculosis", Infect Immun, 68, pp.791~795 (2000)[DOI]
- Esparza-Gonzalez SC, "Recombinant adenovirus delivery of calreticulin-ESAT-6 produces an antigen-specific immune response but no protection against a Mycobacterium tuberculosis challenge", Scand J Immunol, 75, pp.259~265 (2012)[DOI]
- Gurunathan S, "DNA vaccines: immunology, application, and optimization*", Annu Rev Immunol, 18, pp.927~974 (2000)[DOI]
- Feng G, "Enhanced immune response and protective effects of nano-chitosan-based DNA vaccine encoding T cell epitopes of Esat-6 and FL against Mycobacterium tuberculosis infection", PLoS One, 8, pp.e61135~ (2013)[DOI]
- Liang Y, "Ag85A", ESAT-6 chimeric DNA vaccine induces an adverse response in tuberculosis-infected mice, 2016, pp.14, 1146~1152
- Seo H, "IL-21-mediated reversal of NK cell exhaustion facilitates anti-tumour immunity in MHC class I-deficient tumours", Nat Commun, 8, pp.15776~ (2017)[DOI]
- Chung Y, "CD1d-restricted T cells license B cells to generate long-lasting cytotoxic antitumor immunity in vivo", Cancer Res, 66, pp.6843~6850 (2006)[DOI]
- Kim YJ, "alpha-Galactosylceramide-loaded, antigen-expressing B cells prime a wide spectrum of antitumor immunity", Int J Cancer, 122, pp.2774~2783 (2008)[DOI]
- Hong C, "CD4+ T cells in the absence of the CD8+ cytotoxic T cells are critical and sufficient for NKT cell-dependent tumor rejection", J Immunol, 177, pp.6747~6757 (2006)[DOI]
- Chung Y, "An NKT-mediated autologous vaccine generates CD4 T-cell dependent potent antilymphoma immunity", Blood, 110, pp.2013~2019 (2007)[DOI]
- Hong C, "Regulation of secondary antigen-specific CD8(+) T-cell responses by natural killer T cells", Cancer Res, 69, pp.4301~4308 (2009)[DOI]
- de Jonge MI, "ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity", J Bacteriol, 189, pp.6028~6034 (2007)[DOI]
- Seghatoleslam A, "Macrophage immune response suppression by recombinant Mycobacterium tuberculosis antigens, the ESAT-6, CFP-10, and ESAT-6", CFP-10 fusion proteins, 2016, pp.41, 296~304
- Francis RJ, "Mycobacterium tuberculosis ESAT-6 is a leukocidin causing Ca2+ influx, necrosis and neutrophil extracellular trap formation", Cell Death Dis, 5, pp.e1474~ (2014)[DOI]
- Welin A, "Human macrophages infected with a high burden of ESAT-6-expressing M. tuberculosis undergo caspase-1- and cathepsin B-independent necrosis", PLoS One, 6, pp.e20302~ (2011)[DOI]
- Romagnoli A, "ESX-1 dependent impairment of autophagic flux by Mycobacterium tuberculosis in human dendritic cells", Autophagy, 8, pp.1357~1370 (2012)[DOI]
- Dong H, "ESAT6 inhibits autophagy flux and promotes BCG proliferation through MTOR", Biochem Biophys Res Commun, 477, pp.195~201 (2016)[DOI]
- Hsu T, "The primary mechanism of attenuation of Bacillus Calmette-Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue", Proc Natl Acad Sci U S A, 100, pp.12420~12425 (2003)[DOI]
- Smith J, "Evidence for pore formation in host cell membranes by ESX-1-secreted ESAT-6 and its role in Mycobacterium marinum escape from the vacuole", Infect Immun, 76, pp.5478~5487 (2008)[DOI]
- Peng X, "Mechanism of ESAT-6 membrane interaction and its roles in pathogenesis of Mycobacterium tuberculosis", Toxicon, 116, pp.29~34 (2016)[DOI]
- Sreejit G, "The ESAT-6 protein of Mycobacterium tuberculosis interacts with beta-2-microglobulin (beta2M) affecting antigen presentation function of macrophage", PLoS Pathog, 10, pp.e1004446~ (2014)[DOI]
- Sengupta S, "Mycobacterium tuberculosis EsxL inhibits MHC-II expression by promoting hypermethylation in class-II transactivator loci in macrophages", J Biol Chem, 292, pp.6855~6868 (2017)[DOI]
- Watson RO, "The cytosolic sensor cGAS detects Mycobacterium tuberculosis DNA to induce type I interferons and activate autophagy", Cell Host Microbe, 17, pp.811~819 (2015)[DOI]
- Watson RO, "tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing pathway", Cell, 150, pp.803~815 (2012)[DOI]
- Collins AC, "Cyclic GMP-AMP synthase is an innate immune DNA sensor for Mycobacterium tuberculosis", Cell Host Microbe, 17, pp.820~828 (2015)[DOI]
- Wassermann R, "Mycobacterium tuberculosis differentially activates cGAS- and inflammasome-dependent intracellular immune responses through ESX-1", Cell Host Microbe, 17, pp.799~810 (2015)[DOI]
- Koster S, "Mycobacterium tuberculosis is protected from NADPH oxidase and LC3-associated phagocytosis by the LCP protein CpsA", Proc Natl Acad Sci U S A, 114, pp.E8711~E8720 (2017)[DOI]
- McElvania Tekippe E, "Granuloma formation and host defense in chronic Mycobacterium tuberculosis infection requires PYCARD", ASC but not NLRP3 or caspase-1, 2010, pp.5, e12320~
- Saiga H, "Critical role of AIM2 in Mycobacterium tuberculosis infection", Int Immunol, 24, pp.637~644 (2012)[DOI]
- Ruhwald M, "Introducing the ESAT-6 free IGRA, a companion diagnostic for TB vaccines based on ESAT-6", Sci Rep, 7, pp.45969~ (2017)[DOI]
