Downregulation of IL-18 Expression in the Gut by Metformin-induced Gut Microbiota Modulation

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참고문헌 (38)

1. Harrison OJ, "Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3+ Treg cell function in the intestine", Mucosal Immunol, 8, pp.1226~1236 (2015)
2. Guan Q, "Recent advances: the imbalance of cytokines in the pathogenesis of inflammatory bowel disease", Mediators Inflamm, 2017, pp.4810258~ (2017)
3. Berstein LM, "Metformin in obesity, cancer and aging: addressing controversies", Aging (Albany NY), 4, pp.320~329 (2012)
4. Cameron AR, "Anti-inflammatory effects of metformin irrespective of diabetes status", Circ Res, 119, pp.652~665 (2016)
5. Lee SY, "Metformin ameliorates inflammatory bowel disease by suppression of the STAT3 signaling pathway and regulation of the between Th17", Treg balance, 2015, pp.10, e0135858~
6. Sanz Y, "Understanding the role of gut microbiome in metabolic disease risk", Pediatr Res, 77, pp.236~244 (2015)
7. Wu HJ, "The role of gut microbiota in immune homeostasis and autoimmunity", Gut Microbes, 3, pp.4~14 (2012)
8. Hiroko Nagao-Kitamoto, "Host-microbial Cross-talk in Inflammatory Bowel Disease", Immune Network, 17(1), pp.1~12 (2017), 대한면역학회[DOI]
9. Lee H, "Effect of metformin on metabolic improvement and gut microbiota", Appl Environ Microbiol, 80, pp.5935~5943 (2014)
10. Wu H, "Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug", Nat Med, 23, pp.850~858 (2017)
11. Mardinoglu A, "Confounding effects of metformin on the human gut microbiome in type 2 diabetes", Cell Metab, 23, pp.10~12 (2016)
12. Shin NR, "An increase in the Akkermansia spp. Population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice", Gut, 63, pp.727~735 (2014)
13. Lee H, "Modulation of the gut microbiota by metformin improves metabolic profiles in aged obese mice", Gut Microbes, 9, pp.155~165 (2018)
14. Zhao S, "Akkermansia muciniphila improves metabolic profiles by reducing inflammation in chow diet-fed mice", J Mol Endocrinol, 58, pp.1~14 (2017)
15. Everard A, "Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity", Proc Natl Acad Sci U S A, 110, pp.9066~9071 (2013)
16. Schneeberger M, "Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice", Sci Rep, 5, pp.16643~ (2015)
17. Kasai C, "Comparison of the gut microbiota composition between obese and non-obese individuals in a Japanese population, as analyzed by terminal restriction fragment length polymorphism and next-generation sequencing", BMC Gastroenterol, 15, pp.100~ (2015)
18. Rios-Covian D, "Shaping the metabolism of intestinal bacteroides population through diet to improve human health", Front Microbiol, 8, pp.376~ (2017)
19. Zhang Q, "Vildagliptin increases butyrate-producing bacteria in the gut of diabetic rats", PLoS One, 12, pp.e0184735~ (2017)
20. Lin HV, "Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms", PLoS One, 7, pp.e35240~ (2012)
21. Cornick S, "Roles and regulation of the mucus barrier in the gut", Tissue Barriers, 3, pp.e982426~ (2015)
22. Carvalho BM, "Influence of gut microbiota on subclinical inflammation and insulin resistance", Mediators Inflamm, 2013, pp.986734~ (2013)
23. Mirmonsef P, "Short-chain fatty acids induce pro-inflammatory cytokine production alone and in combination with toll-like receptor ligands", Am J Reprod Immunol, 67, pp.391~400 (2012)
24. Li M, "Pro- and anti-inflammatory effects of short chain fatty acids on immune and endothelial cells", Eur J Pharmacol, 831, pp.52~59 (2018)
25. Khoruts A, "Understanding the mechanisms of faecal microbiota transplantation", Nat Rev Gastroenterol Hepatol, 13, pp.508~516 (2016)
26. Kamdar K, "Innate recognition of the microbiota by TLR1 promotes epithelial homeostasis and prevents chronic inflammation", J Immunol, 201, pp.230~242 (2018)
27. Kamdar K, "Genetic and metabolic signals during acute enteric bacterial infection alter the microbiota and drive progression to chronic inflammatory disease", Cell Host Microbe, 19, pp.21~31 (2016)
28. Gupta S, "Analysis of inflammatory cytokine and TLR expression levels in Type 2 Diabetes with complications", Sci Rep, 7, pp.7633~ (2017)
29. Kim F, "Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity", Circ Res, 100, pp.1589~1596 (2007)
30. Velloso LA, "TLR4 at the crossroads of nutrients, gut microbiota, and metabolic inflammation", Endocr Rev, 36, pp.245~271 (2015)
31. Grasset E, "A specific gut microbiota dysbiosis of type 2 diabetic mice induces GLP-1 resistance through an enteric NO-dependent and gut-brain axis mechanism", Cell Metab, 25, pp.1075~1090.e5 (2017)
32. Zietek T, "Inflammation meets metabolic disease: gut feeling mediated by GLP-1", Front Immunol, 7, pp.154~ (2016)
33. Lee YS, "Anti-inflammatory effects of GLP-1-based therapies beyond glucose control", Mediators Inflamm, 2016, pp.3094642~ (2016)
34. Insuela DB, "Glucagon and glucagon-like peptide-1 as novel anti-inflammatory and immunomodulatory compounds", Eur J Pharmacol, pp.64~72 (2017)
35. Kanai T, "Clinical strategies for the blockade of IL-18 in inflammatory bowel diseases", Curr Drug Targets, 14, pp.1392~1399 (2013)
36. Nowarski R, "Epithelial Il-18 equilibrium controls barrier function in colitis", Cell, 163, pp.1444~1456 (2015)
37. Sivakumar PV, "Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage", Gut, 50, pp.812~820 (2002)
38. Lee HM, "Upregulated NLRP3 inflammasome activation in patients with type 2 diabetes", Diabetes, 62, pp.194~204 (2013)

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