Molecular mechanism of reactive oxygen species-dependent ASK1 activation in innate immunity
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Apoptosis signal-regulating kinase 1 (ASK1), a mitogen- activated protein kinase kinase kinase, plays pivotal roles in stress responses. In addition, ASK1 has emerged as a key regulator of immune responses elicited by pathogen-associated molecular patterns (PAMPs) and endogenous danger signals. Recent studies have demonstrated that reactive oxygen species (ROS)-dependent activation of ASK1 is required for LPS-stimulated cytokine production as well as extracellular ATP-induced apoptosis in immune cells. The mechanism of ROS-dependent regulation of ASK1 activity by thioredoxin and TRAFs has been well characterized. In this review, we focus on the molecular details of the activation of ASK1 and its involvement in innate immunity.
Abstract
Apoptosis signal-regulating kinase 1 (ASK1), a mitogen- activated protein kinase kinase kinase, plays pivotal roles in stress responses. In addition, ASK1 has emerged as a key regulator of immune responses elicited by pathogen-associated molecular patterns (PAMPs) and endogenous danger signals. Recent studies have demonstrated that reactive oxygen species (ROS)-dependent activation of ASK1 is required for LPS-stimulated cytokine production as well as extracellular ATP-induced apoptosis in immune cells. The mechanism of ROS-dependent regulation of ASK1 activity by thioredoxin and TRAFs has been well characterized. In this review, we focus on the molecular details of the activation of ASK1 and its involvement in innate immunity.
참고문헌 (38)
- Kyriakis JM, "Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation", Physiol Rev, 81, pp.807~869 (2001)
- Ichijo H, "Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK", JNK and p38 signaling pathways, 1997, pp.275, 90~94
- Nishitoh H, "ASK1 is essential for JNK", SAPK activation by TRAF2, 1998, pp.2, 389~395
- Tobiume K, "ASK1 is required for sustained activations of JNK", p38 MAP kinases and apoptosis, 2001, pp.2, 222~228
- Takeda K, "Involvement of ASK1 in Ca2+-induced p38 MAP kinase activation", EMBO Rep, 5, pp.161~166 (2004)
- Nishitoh H, "ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats", Genes Dev, 16, pp.1345~1355 (2002)
- Akira S, "Pathogen recognition and innate immunity", Cell, 124, pp.783~801 (2006)
- Matsuzawa A, "ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity", Nat Immunol, 6, pp.587~592 (2005)
- Hayakawa T, "The ASK1-MAP kinase pathways in immune and stress responses", Microbes Infect, 8, pp.1098~1107 (2006)
- Skoberne M, "Danger signals: a time and space continuum", Trends Mol Med, 10, pp.251~257 (2004)
- Takeda K, "Apoptosis Signal-Regulating Kinase 1 in Stress and Immune Response", Annu Rev Pharmacol Toxicol (2007)
- Fujino G, "Thioredoxin and protein kinases in redox signaling", Semin Cancer Biol, 16, pp.427~435 (2006)
- Noguchi T, "Recruitment of tumor necrosis factor receptor-associated factor family proteins to apoptosis signal-regulating kinase 1 signalosome is essential for oxidative stress-induced cell death", J Biol Chem, 280, pp.37033~37040 (2005)
- Powis G, "Properties and biological activities of thioredoxins", Annu Rev Biophys Biomol Struct, 30, pp.421~455 (2001)
- Masutani H, "The thioredoxin system in retroviral infection and apoptosis", Cell Death Differ, 12(1), pp.991~998 (2005)
- Saitoh M, "Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1", EMBO J, 17, pp.2596~2606 (1998)
- Fujino G, "Thioredoxin and TRAF family proteins regulate reactive oxygen species-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1", Mol Cell Biol, 27, pp.8152~8163 (2007)
- Liu H, "Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin", Mol Cell Biol, 20, pp.2198~2208 (2000)
- Chung JY, "All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction", J Cell Sci, 115, pp.679~688 (2002)
- Tobiume K, "Activation of apoptosis signal- regulating kinase 1 by the stress-induced activating phosphorylation of pre-formed oligomer", J Cell Physiol, 191, pp.95~104 (2002)
- Ohto U, "Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa", Science, 316, pp.1632~1634 (2007)
- Symons A, "MAP kinase kinase kinases and innate immunity", Trends Immunol, 27, pp.40~48 (2006)
- Huang Q, "Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3", Nat Immunol, 5, pp.98~103 (2004)
- Dumitru CD, "TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2", ERK-dependent pathway, 2000, pp.103, 1071~1083
- Grandvaux N, "Innate host defense: Nox and Duox on phox's tail", Biochimie, 89, pp.1113~1122 (2007)
- Park HS, "Cutting edge: direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kappa B", J Immunol, 173, pp.3589~3593 (2004)
- Chiang E, "Cutting edge: apoptosis-regulating signal kinase 1 is required for reactive oxygen species-mediated activation of IFN regulatory factor 3 by lipopolysaccharide", J Immunol, 176, pp.5720~5724 (2006)
- Bodin P, "Purinergic signalling: ATP release", Neurochem Res, 26, pp.959~969 (2001)
- Khakh BS, "P2X receptors as cell-surface ATP sensors in health and disease", Nature, 442, pp.527~532 (2006)
- Ferrari D, "The P2X7 receptor: a key player in IL-1 processing and release", J Immunol, 176, pp.3877~3883 (2006)
- Lister MF, "The role of the purinergic P2X7 receptor in inflammation", J Inflamm (Lond), 4, pp.5~ (2007)
- Lammas DA, "ATP-induced killing of mycobacteria by human macrophages is mediated by purinergic P2Z(P2X7) receptors", Immunity, 7, pp.433~444 (1997)
- Wang C, "TAK1 is a ubiquitin-dependent kinase of MKK and IKK", Nature, 412, pp.346~351 (2001)
- Adhikari A, "Ubiquitin-mediated activation of TAK1 and IKK", Oncogene, 26, pp.3214~3226 (2007)
- Sato S, "Essential function for the kinase TAK1 in innate and adaptive immune responses", Nat Immunol, 6, pp.1087~1095 (2005)
- Yamamoto M, "Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling", Nat Immunol, 7, pp.962~970 (2006)
- Fukushima T, "Ubiquitin-conjugating enzyme Ubc13 is a critical component of TNF receptor-associated factor (TRAF)-mediated inflammatory responses", Proc Natl Acad Sci USA, 104, pp.6371~6376 (2007)
- Bunkoczi G, "Structural and functional characterization of the human protein kinase ASK1", Structure, 15, pp.1215~1226 (2007)
