The Role of Autophagy in Eosinophilic Airway Inflammation
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Autophagy is a homeostatic mechanism that discards not only invading pathogens but also damaged organelles and denatured proteins via lysosomal degradation. Increasing evidence suggests a role for autophagy in inflammatory diseases, including infectious diseases, Crohn's disease, cystic fibrosis, and pulmonary hypertension. These studies suggest that modulating autophagy could be a novel therapeutic option for inflammatory diseases. Eosinophils are a major type of inflammatory cell that aggravates airway inflammatory diseases, particularly corticosteroid-resistant inflammation. The eosinophil count is a useful tool for assessing which patients may benefit from inhaled corticosteroid therapy. Recent studies demonstrate that autophagy plays a role in eosinophilic airway inflammatory diseases by promoting airway remodeling and loss of function. Genetic variant in the autophagy gene ATG5 is associated with asthma pathogenesis, and autophagy regulates apoptotic pathways in epithelial cells in individuals with chronic obstructive pulmonary disease. Moreover, autophagy dysfunction leads to severe inflammation, especially eosinophilic inflammation, in chronic rhinosinusitis. However, the mechanism underlying autophagy-mediated regulation of eosinophilic airway inflammation remains unclear. The aim of this review is to provide a general overview of the role of autophagy in eosinophilic airway inflammation. We also suggest that autophagy may be a new therapeutic target for airway inflammation, including that mediated by eosinophils.
Abstract
Autophagy is a homeostatic mechanism that discards not only invading pathogens but also damaged organelles and denatured proteins via lysosomal degradation. Increasing evidence suggests a role for autophagy in inflammatory diseases, including infectious diseases, Crohn's disease, cystic fibrosis, and pulmonary hypertension. These studies suggest that modulating autophagy could be a novel therapeutic option for inflammatory diseases. Eosinophils are a major type of inflammatory cell that aggravates airway inflammatory diseases, particularly corticosteroid-resistant inflammation. The eosinophil count is a useful tool for assessing which patients may benefit from inhaled corticosteroid therapy. Recent studies demonstrate that autophagy plays a role in eosinophilic airway inflammatory diseases by promoting airway remodeling and loss of function. Genetic variant in the autophagy gene ATG5 is associated with asthma pathogenesis, and autophagy regulates apoptotic pathways in epithelial cells in individuals with chronic obstructive pulmonary disease. Moreover, autophagy dysfunction leads to severe inflammation, especially eosinophilic inflammation, in chronic rhinosinusitis. However, the mechanism underlying autophagy-mediated regulation of eosinophilic airway inflammation remains unclear. The aim of this review is to provide a general overview of the role of autophagy in eosinophilic airway inflammation. We also suggest that autophagy may be a new therapeutic target for airway inflammation, including that mediated by eosinophils.
참고문헌 (80)
- Levine B, "Autophagy in immunity and inflammation", Nature, 469, pp.323~335 (2011)
- Kaipeng Jing, "Why is autophagy important in human diseases?", Experimental and Molecular Medicine, 44(2), pp.69~72 (2012), 생화학분자생물학회
- Harris J, "Autophagy and inflammasomes", Mol Immunol, 86, pp.10~15 (2017)
- Fougeray S, "Mechanisms and biological functions of autophagy in diseased and ageing kidneys", Nat Rev Nephrol, 11, pp.34~45 (2015)
- Pan H, "Autophagy-associated immune responses and cancer immunotherapy", Oncotarget, 7, pp.21235~21246 (2016)
- Lee JA, "Autophagy in neurodegenerative diseases", Brain Res, 1649, pp.141~142 (2016)
- Lai CH, "Multi-strain probiotics inhibit cardiac myopathies and autophagy to prevent heart injury in high-fat diet-fed rats", Int J Med Sci, 13, pp.277~285 (2016)
- Mizushima N, "Methods in mammalian autophagy research", Cell, 140, pp.313~326 (2010)
- Xie Z, "Autophagosome formation: core machinery and adaptations", Nat Cell Biol, 9, pp.1102~1109 (2007)
- Qian M, "Autophagy and inflammation", Clin Transl Med, 6, pp.24~ (2017)
- Oh JE, "Modulation of pathogen recognition by autophagy", Front Immunol, 3, pp.44~ (2012)
- Riffelmacher T, "Mechanistic roles of autophagy in hematopoietic differentiation", FEBS J, 284, pp.1008~1020 (2017)
- El-Khider F, "Links of autophagy dysfunction to inflammatory bowel disease onset", Dig Dis, 34, pp.27~34 (2016)
- Jyothula SS, "Autophagy and role in asthma", Curr Opin Pulm Med, 19, pp.30~35 (2013)
- Chen JY, "Autophagy is deficient in nasal polyps: implications for the pathogenesis of the disease", Int Forum Allergy Rhinol, 5, pp.119~123 (2015)
- Wang LF, "Autophagy is deficient and inversely correlated with COX-2 expression in nasal polyps: a novel insight into the inflammation mechanism", Rhinology, 53, pp.270~276 (2015)
- Choi GE, "Autophagy deficiency in myeloid cells exacerbates eosinophilic inflammation in chronic rhinosinusitis", J Allergy Clin Immunol, 141, pp.938~950.e12 (2018)
- Martin LJ, "Functional variant in the autophagy-related 5 gene promotor is associated with childhood asthma", PLoS One, 7, pp.e33454~ (2012)
- Poon A, "ATG5, autophagy and lung function in asthma", Autophagy, 8, pp.694~695 (2012)
- Poon AH, "Genetic and histologic evidence for autophagy in asthma pathogenesis", J Allergy Clin Immunol, 129, pp.569~571 (2012)
- Lapa e Silva JR, "Role of eosinophilic airway inflammation in models of asthma", Mem Inst Oswaldo Cruz, 92(Suppl 2), pp.223~226 (1997)
- Rothenberg ME, "The eosinophil", Annu Rev Immunol, 24, pp.147~174 (2006)
- George L, "Eosinophilic airway inflammation: role in asthma and chronic obstructive pulmonary disease", Ther Adv Chronic Dis, 7, pp.34~51 (2016)
- Conroy DM, "Eotaxin and the attraction of eosinophils to the asthmatic lung", Respir Res, 2, pp.150~156 (2001)
- Hogan SP, "Eosinophils: biological properties and role in health and disease", Clin Exp Allergy, 38, pp.709~750 (2008)
- Davoine F, "Eosinophil cytokines, chemokines, and growth factors: emerging roles in immunity", Front Immunol, 5, pp.570~ (2014)
- Levi-Schaffer F, "Human eosinophils regulate human lung- and skin-derived fibroblast properties in vitro: a role for transforming growth factor beta (TGF-beta)", Proc Natl Acad Sci U S A, 96, pp.9660~9665 (1999)
- Makinde T, "The regulatory role of TGF-beta in airway remodeling in asthma", Immunol Cell Biol, 85, pp.348~356 (2007)
- Murdoch JR, "Chronic inflammation and asthma", Mutat Res, 690, pp.24~39 (2010)
- Umetsu DT, "The regulation of allergy and asthma", Immunol Rev, 212, pp.238~255 (2006)
- KleinJan A, "Airway inflammation in asthma: key players beyond the Th2 pathway", Curr Opin Pulm Med, 22, pp.46~52 (2016)
- Corrigan CJ, "T cells and eosinophils in the pathogenesis of asthma", Immunol Today, 13, pp.501~507 (1992)
- Kay AB, "The role of eosinophils in the pathogenesis of asthma", Trends Mol Med, 11, pp.148~152 (2005)
- Olaguibel JM, "Measurement of asthma control according to global initiative for asthma guidelines: a comparison with the asthma control questionnaire", Respir Res, 13, pp.50~ (2012)
- Cosmi L, "Th17 cells: new players in asthma pathogenesis", Allergy, 66, pp.989~998 (2011)
- Alcorn JF, "TH17 cells in asthma and COPD", Annu Rev Physiol, 72, pp.495~516 (2010)
- Louis R, "The relationship between airways inflammation and asthma severity", Am J Respir Crit Care Med, 161, pp.9~16 (2000)
- Woodruff PG, "Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma", J Allergy Clin Immunol, 108, pp.753~758 (2001)
- Wilson RH, "llergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness", Am J Respir Crit Care Med, 180, pp.720~730 (2009)
- Jing-Nan Liu, "The role of autophagy in allergic inflammation: a new target for severe asthma", Experimental and Molecular Medicine, 48, pp.1~10 (2016), 생화학분자생물학회
- Suzuki Y, "Lack of autophagy induces steroid-resistant airway inflammation", J Allergy Clin Immunol, 137, pp.1382~1389.e9 (2016)
- Ghavami S, "Autophagy is a regulator of TGF-β1-induced fibrogenesis in primary human atrial myofibroblasts", Cell Death Dis, 6, pp.e1696~ (2015)
- Kielan D. McAlinden, "Autophagy Activation in Asthma Airways Remodeling", American Journal of Respiratory Cell and Molecular Biology, 60(5), pp.541~553 (2019), American Thoracic Society[DOI]
- Yeganeh B, "Suppression of influenza A virus replication in human lung epithelial cells by noncytotoxic concentrations bafilomycin A1", Am J Physiol Lung Cell Mol Physiol, 308, pp.L270~L286 (2015)
- Prentice E, "Coronavirus replication complex formation utilizes components of cellular autophagy", J Biol Chem, 279, pp.10136~10141 (2004)
- Cottam EM, "Coronavirus nsp6 proteins generate autophagosomes from the endoplasmic reticulum via an omegasome intermediate", Autophagy, 7, pp.1335~1347 (2011)
- Barnes PJ, "Inflammatory mechanisms in patients with chronic obstructive pulmonary disease", J Allergy Clin Immunol, 138, pp.16~27 (2016)
- Rabe KF, "Chronic obstructive pulmonary disease", Lancet, 389, pp.1931~1940 (2017)
- Vogelmeier CF, "Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 report: GOLD executive summary", Eur Respir J, 49, pp.1700214~ (2017)
- Saha S, "Eosinophilic airway inflammation in COPD", Int J Chron Obstruct Pulmon Dis, 1, pp.39~47 (2006)
- Tashkin DP, "Role of eosinophils in airway inflammation of chronic obstructive pulmonary disease", Int J Chron Obstruct Pulmon Dis, 13, pp.335~349 (2018)
- hen ZH, "Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease", PLoS One, 3, pp.e3316~ (2008)
- Kim HP, "Autophagic proteins regulate cigarette smoke-induced apoptosis: protective role of heme oxygenase-1", Autophagy, 4, pp.887~895 (2008)
- Chen ZH, "Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema", Proc Natl Acad Sci U S A, 107, pp.18880~18885 (2010)
- Kiffin R, "Oxidative stress and autophagy", Antioxid Redox Signal, 8, pp.152~162 (2006)
- Kirkham PA, "Oxidative stress in COPD", Chest, 144, pp.266~273 (2013)
- Ryter SW, "Autophagy in cigarette smoke-induced chronic obstructive pulmonary disease", Expert Rev Respir Med, 4, pp.573~584 (2010)
- Scherz-Shouval R, "Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4", EMBO J, 26, pp.1749~1760 (2007)
- Chen Y, "Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells", Cell Death Differ, 15, pp.171~182 (2008)
- Gamble E, "Airway mucosal inflammation in COPD is similar in smokers and ex-smokers: a pooled analysis", Eur Respir J, 30, pp.467~471 (2007)
- Fokkens WJ, "EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists", Rhinology, 50, pp.1~12 (2012)
- Stevens WW, "Chronic rhinosinusitis pathogenesis", J Allergy Clin Immunol, 136, pp.1442~1453 (2015)
- Van Crombruggen K, "Pathogenesis of chronic rhinosinusitis: inflammation", J Allergy Clin Immunol, 128, pp.728~732 (2011)
- Kato A, "Immunopathology of chronic rhinosinusitis", Allergol Int, 64, pp.121~130 (2015)
- López-Chacón M, "Clinical and biological markers of difficult-to-treat severe chronic rhinosinusitis", Curr Allergy Asthma Rep, 15, pp.19~ (2015)
- Shah SA, "Pathogenesis of eosinophilic chronic rhinosinusitis", J Inflamm (Lond), 13, pp.11~ (2016)
- Cho SW, "Classification of chronic rhinosinusitis according to a nasal polyp and tissue eosinophilia: limitation of current classification system for Asian population", Asia Pac Allergy, 7, pp.121~130 (2017)
- Van Zele T, "Differentiation of chronic sinus diseases by measurement of inflammatory mediators", Allergy, 61, pp.1280~1289 (2006)
- Zhang N, "Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease", J Allergy Clin Immunol, 122, pp.961~968 (2008)
- Cao PP, "Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese", J Allergy Clin Immunol, 124, pp.478~484 (2009)
- Kim JW, "Histological and immunological features of non-eosinophilic nasal polyps", Otolaryngol Head Neck Surg, 137, pp.925~930 (2007)
- Ikeda K, "Subclassification of chronic rhinosinusitis with nasal polyp based on eosinophil and neutrophil", Laryngoscope, 123, pp.E1~E9 (2013)
- Mahdavinia M, "Increased noneosinophilic nasal polyps in chronic rhinosinusitis in US second-generation Asians suggest genetic regulation of eosinophilia", J Allergy Clin Immunol, 135, pp.576~579 (2015)
- Di Lorenzo G, "Measurement of inflammatory mediators of mast cells and eosinophils in native nasal lavage fluid in nasal polyposis", Int Arch Allergy Immunol, 125, pp.164~175 (2001)
- Pawankar R, "Role of mast cells and basophils in chronic rhinosinusitis", Clin Allergy Immunol, 20, pp.93~101 (2007)
- Yoshimura T, "Correlation between the prostaglandin D(2)", E(2) ratio in nasal polyps and the recalcitrant pathophysiology of chronic rhinosinusitis associated with bronchial asthma, 2008, pp.57, 429~436
- Okano M, "Role of prostaglandin D2 and E2 terminal synthases in chronic rhinosinusitis", Clin Exp Allergy, 36, pp.1028~1038 (2006)
- Ilyas G, "Macrophage autophagy limits acute toxic liver injury in mice through down regulation of interleukin-1β", J Hepatol, 64, pp.118~127 (2016)
- Lee HY, "Autophagy deficiency in myeloid cells increases susceptibility to obesity-induced diabetes and experimental colitis", Autophagy, 12, pp.1390~1403 (2016)
- Castillo EF, "Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation", Proc Natl Acad Sci U S A, 109, pp.E3168~E3176 (2012)