본문 바로가기
KERD
논문KCI 등재

The Impact of Pulmonary Disorders on Neurological Health (Lung-Brain Axis)

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

초록

The brain and lungs, vital organs in the body, play essential roles in maintaining overall well-being and survival. These organs interact through complex and sophisticated bi-directional pathways known as the 'lung–brain axis', facilitated by their close proximity and neural connections. Numerous studies have underscored the mediation of the lung-brain axis by inflammatory responses and hypoxia-induced damage, which are pivotal to the progression of both pulmonary and neurological diseases. This review aims to delve into how pulmonary diseases, including acute/chronic airway diseases and pulmonary conditions, can instigate neurological disorders such as stroke, Alzheimer’s disease, and Parkinson's disease. Additionally, we highlight the emerging research on the lung microbiome which, drawing parallels between the gut and lungs in terms of microbiome contents, may play a significant role in modulating brain health. Ultimately, this review paves the way for exciting avenues of future research and therapeutics in addressing respiratory and neurological diseases.

Abstract

The brain and lungs, vital organs in the body, play essential roles in maintaining overall well-being and survival. These organs interact through complex and sophisticated bi-directional pathways known as the 'lung–brain axis', facilitated by their close proximity and neural connections. Numerous studies have underscored the mediation of the lung-brain axis by inflammatory responses and hypoxia-induced damage, which are pivotal to the progression of both pulmonary and neurological diseases. This review aims to delve into how pulmonary diseases, including acute/chronic airway diseases and pulmonary conditions, can instigate neurological disorders such as stroke, Alzheimer’s disease, and Parkinson's disease. Additionally, we highlight the emerging research on the lung microbiome which, drawing parallels between the gut and lungs in terms of microbiome contents, may play a significant role in modulating brain health. Ultimately, this review paves the way for exciting avenues of future research and therapeutics in addressing respiratory and neurological diseases.

참고문헌 (184)

  1. Cipolla MJ, "The Cerebral Circulation" (2009), Morgan & Claypool Life Sciences
  2. Ogoh S, "Interaction between the respiratory system and cerebral blood flow regulation", J Appl Physiol, 127, pp.1197~1205 (2019)
  3. Mergenthaler P, "Sugar for the brain : the role of glucose in physiological and pathological brain function", Trends Neurosci, 36, pp.587~597 (2013)
  4. Sethi D, "Anatomy, Head and Neck: Carotid Arteries" (2023), StatPearls Publishing
  5. Cummins EP, "Mechanisms and consequences of oxygen and carbon dioxide sensing in mammals", Physiol Rev, 100, pp.463~488 (2020)
  6. Murphy PB, "Effect of home noninvasive ventilation with oxygen therapy vs oxygen therapy alone on hospital readmission or death after an acute COPD exacerbation : a randomized clinical trial", JAMA, 317, pp.2177~2186 (2017)
  7. Laffey JG, "Carbon dioxide and the critically ill--too little of a good thing?", Lancet, 354, pp.1283~1286 (1999)
  8. Nattie E, "Central chemoreceptors : locations and functions", Compr Physiol, 2, pp.221~254 (2012)
  9. Hattori T, "DNA ploidy patterns of minute carcinomas in the stomach", Jpn J Cancer Res, 77, pp.276~281 (1986)
  10. Rummel C, "1st european psychoneuroimmunology network(epn)autumn school : Lung-brain axis in health and disease", Neuroimmunomodulation, 29(Suppl 2), pp.3~8 (2022)
  11. Aghasafari P, "A review of inflammatory mechanism in airway diseases", Inflamm Res, 68, pp.59~74 (2019)
  12. Sonar SA, "Blood-brain barrier and its function during inflammation and autoimmunity", J Leukoc Biol, 103, pp.839~853 (2018)
  13. Mapunda JA, "How does the immune system enter the brain?", Front Immunol, 13, pp.805657~ (2022)
  14. Luster AD, "Immune cell migration in inflammation : present and future therapeutic targets", Nat Immunol, 6, pp.1182~1190 (2005)
  15. Chen J, "The lung microbiome : a new frontier for lung and brain disease", Int J Mol Sci, 24, pp.2170~ (2023)
  16. Yagi K, "The lung microbiome during health and disease", Int J Mol Sci, 22, pp.10872~ (2021)
  17. Charlson ES, "Topographical continuity of bacterial populations in the healthy human respiratory tract", Am J Respir Crit Care Med, 184, pp.957~963 (2011)
  18. Natalini JG, "The dynamic lung microbiome in health and disease", Nat Rev Microbiol, 21, pp.222~235 (2023)
  19. Hou K, "Microbiota in health and diseases", Signal Transduct Target Ther, 7, pp.135~ (2022)
  20. Louveau A, "Revisiting the mechanisms of CNS immune privilege", Trends Immunol, 36, pp.569~577 (2015)
  21. Ardain A, "Tissue-resident innate immunity in the lung", Immunology, 159, pp.245~256 (2020)
  22. Kim YM, "Airway G-CSF identifies neutrophilic inflammation and contributes to asthma progression", Eur Respir J, 55, pp.1900827~ (2020)
  23. Dantzer R, "From inflammation to sickness and depression : when the immune system subjugates the brain", Nat Rev Neurosci, 9, pp.46~56 (2008)
  24. Cheng W, "Higher systemic immune-inflammation index and systemic inflammation response index levels are associated with stroke prevalence in the asthmatic population : a cross-sectional analysis of the NHANES 1999-2018", Front Immunol, 14, pp.1191130~ (2023)
  25. Sonneville R, "Understanding brain dysfunction in sepsis", Ann Intensive Care, 3, pp.15~ (2013)
  26. Torres A, "Pneumonia", Nat Rev Dis Primers, 7, pp.25~ (2021)
  27. Shah FA, "Bidirectional relationship between cognitive function and pneumonia", Am J Respir Crit Care Med, 188, pp.586~592 (2013)
  28. Chu CS, "Bacterial pneumonia and subsequent dementia risk : a nationwide cohort study", Brain Behav Immun, 103, pp.12~18 (2022)
  29. Huang M, "Pathophysiology of brain injury and neurological outcome in acute respiratory distress syndrome : a scoping review of preclinical to clinical studies", Neurocrit Care, 35, pp.518~527 (2021)
  30. Girard TD, "Clinical phenotypes of delirium during critical illness and severity of subsequent long-term cognitive impairment : a prospective cohort study", Lancet Respir Med, 6, pp.213~222 (2018)
  31. Irani F, "Is asthma associated with cognitive impairments? A meta-analytic review", J Clin Exp Neuropsychol, 39, pp.965~978 (2017)
  32. Nair AK, "Asthma amplifies dementia risk : evidence from CSF biomarkers and cognitive decline", Alzheimers Dement(N Y), 8, pp.e12315~ (2022)
  33. Nair AK, "Impact of asthma on the brain : evidence from diffusion MRI, CSF biomarkers and cognitive decline", Brain Commun, 5, pp.fcad180~ (2023)
  34. Ren M, "Allergic asthma-induced cognitive impairment is alleviated by dexamethasone", Front Pharmacol, 12, pp.680815~ (2021)
  35. Stoll P, "Stage-dependent association of BDNF and TGF-β1 with lung function in stable COPD", Respir Res, 13, pp.116~ (2012)
  36. Lahiri DK, "Are pulmonary fibrosis and Alzheimer’s disease linked? Shared dysregulation of two miRNA species and downstream pathways accompany both disorders", J Biol Chem, 292, pp.20353~ (2017)
  37. White J, "Cognitive, emotional, and quality of life outcomes in patients with pulmonary arterial hypertension", Respir Res, 7, pp.55~ (2006)
  38. Bussotti M, "Anxiety and depression in patients with pulmonary hypertension : impact and management challenges", Vasc Health Risk Manag, 14, pp.349~360 (2018)
  39. D’Orléans-Juste P, "Endothelins in inflammatory neurological diseases", Pharmacol Ther, 194, pp.145~160 (2019)
  40. Mendiola AS, "The IL-1β phenomena in neuroinflammatory diseases", J Neural Transm(Vienna), 125, pp.781~795 (2018)
  41. Correction to, "Temporal profile of pneumonia after stroke", Stroke, 53, pp.e129~ (2022)
  42. Ghandour RM, "Prevalence and treatment of depression, anxiety, and conduct problems in us children", J Pediatr, 206, pp.256~267 (2019)
  43. Wang T, "Asthma’s effect on brain connectivity and cognitive decline", Front Neurol, 13, pp.1065942~ (2023)
  44. Fabisiak T, "Crosstalk between neuroinflammation and oxidative stress in epilepsy", Front Cell Dev Biol, 10, pp.976953~ (2022)
  45. Chiang KL, "Association of epilepsy and asthma : a population-based retrospective cohort study", PeerJ, 6, pp.e4792~ (2018)
  46. Li J, "The evaluation of cognitive impairment and relevant factors in patients with chronic obstructive pulmonary disease", Respiration, 85, pp.98~105 (2013)
  47. Torres-Sánchez I, "Cognitive impairment in COPD : a systematic review", J Bras Pneumol, 41, pp.182~190 (2015)
  48. Li CH, "The association between chronic obstructive pulmonary disease and Parkinson’s disease : a nationwide population-based retrospective cohort study", QJM, 108, pp.39~45 (2015)
  49. Ranzini L, "From mild cognitive impairment(MCI)to dementia in chronic obstructive pulmonary disease. Implications for clinical practice and disease management : a mini-review", Front Psychol, 11, pp.337~ (2020)
  50. Xiao T, "Lung function impairment and the risk of incident dementia : the Rotterdam study", J Alzheimers Dis, 82, pp.621~630 (2021)
  51. Hambali A, "Hypoxia-induced neuroinflammation in Alzheimer’s disease : potential neuroprotective effects of Centella asiatica", Front Physiol, 12, pp.712317~ (2021)
  52. Shi H, "Hypoxia inducible factor 1 as a therapeutic target in ischemic stroke", Curr Med Chem, 16, pp.4593~4600 (2009)
  53. Aliberti S, "Delirium symptoms during hospitalization predict long-term mortality in patients with severe pneumonia", Aging Clin Exp Res, 27, pp.523~531 (2015)
  54. Xu W, "The implication of oxidative stress and ampk-nrf2 antioxidative signaling in pneumonia pathogenesis", Front Endocrinol(Lausanne), 11, pp.400~ (2020)
  55. Feldman C, "Meningococcal pneumonia : a review", Pneumonia, 11, pp.3~ (2019)
  56. Viegas CA, "Prevalence of risk factors for obstructive sleep apnea syndrome in interstate bus drivers", J Bras Pneumol, 32, pp.144~149 (2006)
  57. Liu Z, "Association between inflammatory biomarkers and acute respiratory distress syndrome or acute lung injury risk : A systematic review and meta-analysis", Wien Klin Wochenschr, 134, pp.24~38 (2022)
  58. Taghavi S, "Interleukin-22 mitigates acute respiratory distress syndrome(ARDS)", PLoS One, 16, pp.e0254985~ (2021)
  59. Adhikari NK, "Self-reported symptoms of depression and memory dysfunction in survivors of ARDS", Chest, 135, pp.678~687 (2009)
  60. Ziaka M, "ARDS associated acute brain injury : from the lung to the brain", Eur J Med Res, 27, pp.150~ (2022)
  61. Jaecklin T, "Do soluble mediators cause ventilator-induced lung injury and multi-organ failure?", Intensive Care Med, 36, pp.750~757 (2010)
  62. Robba C, "Ards and neurological outcome : there is not just one organ to protect!", Neurocrit Care, 35, pp.297~298 (2021)
  63. Tsagkaris C, "Cytokine storm and neuropathological alterations in patients with neurological manifestations of COVID-19", Curr Alzheimer Res, 19, pp.641~657 (2022)
  64. Corlateanu A, "Asthma and stroke : a narrative review", Asthma Res Pract, 7, pp.3~ (2021)
  65. Austin V, "COPD and stroke : are systemic inflammation and oxidative stress the missing links?", Clin Sci(Lond), 130, pp.1039~1050 (2016)
  66. Didier N, "Secretion of interleukin-1beta by astrocytes mediates endothelin-1 and tumour necrosis factor-alpha effects on human brain microvascular endothelial cell permeability", J Neurochem, 86, pp.246~254 (2003)
  67. Cifuentes D, "Hypertension accelerates the progression of Alzheimer-like pathology in a mouse model of the disease", Hypertension, 65, pp.218~224 (2015)
  68. Shah TG, "The association between pulmonary hypertension and stroke : a systematic review and meta-analysis", Int J Cardiol, 295, pp.21~24 (2019)
  69. Ho CH, "Impact of grouping complications on mortality in traumatic brain injury : a nationwide population-based study", PLoS One, 13, pp.e0190683~ (2018)
  70. Zygun DA, "Ventilator-associated pneumonia in severe traumatic brain injury", Neurocrit Care, 5, pp.108~114 (2006)
  71. Balczon R, "Pneumonia initiates a tauopathy", FASEB J, 35, pp.e21807~ (2021)
  72. Scott AM, "Pneumonia-induced endothelial amyloids reduce dendritic spine density in brain neurons", Sci Rep, 10, pp.9327~ (2020)
  73. Villalba N, "Lung infection by Pseudomonas aeruginosa induces neuroinflammation and blood-brain barrier dysfunction in mice", J Neuroinflammation, 20, pp.127~ (2023)
  74. Rodríguez-Lucas C, "Pseudomonas aeruginosa nosocomial meningitis in neurosurgical patients with intraventricular catheters : therapeutic approach and review of the literature", Enferm Infecc Microbiol Clin(Engl Ed), 38, pp.54~58 (2020)
  75. Ma Q, "Neurological disorders after severe pneumonia are associated with translocation of endogenous bacteria from the lung to the brain", Sci Adv, 9, pp.eadi0699~ (2023)
  76. Diamond M, "Acute Respiratory Distress Syndrome" (2023), StatPearls Publishing
  77. Matthay MA, "Acute respiratory distress syndrome", Nat Rev Dis Primers, 5, pp.18~ (2019)
  78. Herridge MS, "Recovery and outcomes after the acute respiratory distress syndrome(ARDS)in patients and their family caregivers", Intensive Care Med, 42, pp.725~738 (2016)
  79. Wilcox ME, "Cognitive dysfunction in ICU patients : risk factors, predictors, and rehabilitation interventions", Crit Care Med, 41, pp.S81~ (2013)
  80. Kapfhammer HP, "Posttraumatic stress disorder and health-related quality of life in long-term survivors of acute respiratory distress syndrome", Am J Psychiatry, 161, pp.45~52 (2004)
  81. Mikkelsen ME, "Cognitive, mood and quality of life impairments in a select population of ARDS survivors", Respirology, 14, pp.76~82 (2009)
  82. Herridge MS, "Functional disability 5 years after acute respiratory distress syndrome", N Engl J Med, 364, pp.1293~1304 (2011)
  83. Mart MF, "The long-lasting effects of the acute respiratory distress syndrome", Expert Rev Respir Med, 14, pp.577~586 (2020)
  84. Hopkins RO, "Neuropsychological sequelae and impaired health status in survivors of severe acute respiratory distress syndrome", Am J Respir Crit Care Med, 160, pp.50~56 (1999)
  85. Bienvenu OJ, "Psychiatric symptoms after acute respiratory distress syndrome : a 5-year longitudinal study", Intensive Care Med, 44, pp.38~47 (2018)
  86. Hsieh SJ, "The association between acute respiratory distress syndrome, delirium, and in-hospital mortality in intensive care unit patients", Am J Respir Crit Care Med, 191, pp.71~78 (2015)
  87. Dolinay T, "Inflammasome-regulated cytokines are critical mediators of acute lung injury", Am J Respir Crit Care Med, 185, pp.1225~1234 (2012)
  88. Ye L, "IL-1β and TNF-α induce neurotoxicity through glutamate production : a potential role for neuronal glutaminase", J Neurochem, 125, pp.897~908 (2013)
  89. Lampl Y, "Minocycline treatment in acute stroke : an open-label, evaluator-blinded study", Neurology, 69, pp.1404~1410 (2007)
  90. Zabad RK, "The clinical response to minocycline in multiple sclerosis is accompanied by beneficial immune changes : a pilot study", Mult Scler, 13, pp.517~526 (2007)
  91. NINDS NET-PD Investigators, "A randomized, double-blind, futility clinical trial of creatine and minocycline in early Parkinson disease", Neurology, 66, pp.664~671 (2006)
  92. Peukert K, "Inhibition of caspase-1 with tetracycline ameliorates acute lung injury", Am J Respir Crit Care Med, 204, pp.53~63 (2021)
  93. Fries M, "S-100 protein and neurohistopathologic changes in a porcine model of acute lung injury", Anesthesiology, 102, pp.761~767 (2005)
  94. Bickenbach J, "Neurological outcome after experimental lung injury", Respir Physiol Neurobiol, 179, pp.174~180 (2011)
  95. Song P, "Global, regional, and national prevalence of asthma in 2019 : a systematic analysis and modelling study", J Glob Health, 12, pp.04052~ (2022)
  96. Chabra R, "Allergic and Environmentally Induced Asthma" (2023), StatPearls Publishing
  97. Sánchez-Borges M, "International consensus(ICON)on : clinical consequences of mite hypersensitivity, a global problem", World Allergy Organ J, 10, pp.14~ (2017)
  98. Huang HJ, "House dust mite allergy : the importance of house dust mite allergens for diagnosis and immunotherapy", Mol Immunol, 158, pp.54~67 (2023)
  99. Kanaya A, "Chronic allergic lung inflammation negatively influences neurobehavioral outcomes in mice", J Neuroinflammation, 19, pp.210~ (2022)
  100. Johnson DB, "Dexamethasone" (2023), StatPearls Publishing
  101. Bathina S, "Brain-derived neurotrophic factor and its clinical implications", Arch Med Sci, 11, pp.1164~1178 (2015)
  102. Miranda M, "Brain-derived neurotrophic factor : a key molecule for memory in the healthy and the pathological brain", Front Cell Neurosci, 13, pp.363~ (2019)
  103. Janicijevic SM, "Interplay of brain-derived neurotrophic factor and cytokines in schizophrenia", Exp Appl Biomed Res, 21, pp.283~289 (2020)
  104. Wang S, "Secreted brain-derived neurotrophic factor and asthma severity", Am J Respir Cell Mol Biol, 54, pp.297~ (2016)
  105. Sreter KB, "Plasma brain-derived neurotrophic factor(BDNF)concentration and BDNF", TRKB gene polymorphisms in Croatian adults with asthma, 2020, pp.10, 189~
  106. Britt RD Jr, "Smooth muscle brain-derived neurotrophic factor contributes to airway hyperreactivity in a mouse model of allergic asthma", FASEB J, 33, pp.3024~3034 (2019)
  107. Hahn C, "Airway epithelial cells produce neurotrophins and promote the survival of eosinophils during allergic airway inflammation", J Allergy Clin Immunol, 117, pp.787~794 (2006)
  108. Singh D, "Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease : The gold science committee report 2019", Eur Respir J, 53, pp.1900164~ (2019)
  109. Qin W, "The relationship between chronic obstructive pulmonary disease and cerebral small vessel disease assessed by magnetic resonance imaging : a case-control study from a single center in Beijing, China", Med Sci Monit, 26, pp.e925703~ (2020)
  110. Yin M, "Patterns of brain structural alteration in COPD with different levels of pulmonary function impairment and its association with cognitive deficits", BMC Pulm Med, 19, pp.203~ (2019)
  111. Liu CC, "Apolipoprotein E and Alzheimer disease : risk, mechanisms and therapy", Nat Rev Neurol, 9, pp.106~118 (2013)
  112. Koutsodendris N, "Neuronal ApoE4 removal protects against tau-mediated gliosis, neurodegeneration and myelin deficits", Nat Aging, 3, pp.275~296 (2023)
  113. Rusanen M, "Midlife smoking, apolipoprotein E and risk of dementia and Alzheimer’s disease : a population-based cardiovascular risk factors, aging and dementia study", Dement Geriatr Cogn Disord, 30, pp.277~284 (2010)
  114. Tjärnlund-Wolf A, "Plasminogen activator inhibitor-1 and thrombotic cerebrovascular diseases", Stroke, 43, pp.2833~2839 (2012)
  115. Donaldson GC, "Increased risk of myocardial infarction and stroke following exacerbation of COPD", Chest, 137, pp.1091~1097 (2010)
  116. Waschki B, "Plasminogen activator inhibitor-1 is elevated in patients with COPD independent of metabolic and cardiovascular function", Int J Chron Obstruct Pulmon Dis, 12, pp.981~987 (2017)
  117. Todd NW, "Molecular and cellular mechanisms of pulmonary fibrosis", Fibrogenesis Tissue Repair, 5, pp.11~ (2012)
  118. Ma H, "Targeting growth factor and cytokine pathways to treat idiopathic pulmonary fibrosis", Front Pharmacol, 13, pp.918771~ (2022)
  119. Piersma B, "Signaling in fibrosis : TGF-β, WNT, and YAP", TAZ converge, 2015, pp.2, 59~
  120. Zhao M, "Targeting fibrosis, mechanisms and cilinical trials", Signal Transduct Target Ther, 7, pp.206~ (2022)
  121. Shill H, "Respiratory complications of Parkinson’s disease", Semin Respir Crit Care Med, 23, pp.261~265 (2002)
  122. Bors M, "Cognitive function in idiopathic pulmonary fibrosis", Chron Respir Dis, 12, pp.365~372 (2015)
  123. Mohammadi-Nejad AR, "Mapping brain endophenotypes associated with idiopathic pulmonary fibrosis genetic risk", EBioMedicine, 86, pp.104356~ (2022)
  124. Jamialahmadi H, "Targeting transforming growth factor beta(TGF-β)using Pirfenidone, a potential repurposing therapeutic strategy in colorectal cancer", Sci Rep, 13, pp.14357~ (2023)
  125. Bozkurt I, "Effects of pirfenidone on experimental head injury in rats", Int J Clin Exp Pathol, 15, pp.20~28 (2022)
  126. von Bernhardi R, "Role of TGFβ signaling in the pathogenesis of Alzheimer’s disease", Front Cell Neurosci, 9, pp.426~ (2015)
  127. Wyss-Coray T, "TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice", Nat Med, 7, pp.612~618 (2001)
  128. Hu Y, "Wnt signalling in lung physiology and pathology", Handb Exp Pharmacol, 269, pp.305~336 (2021)
  129. Königshoff M, "Functional Wnt signaling is increased in idiopathic pulmonary fibrosis", PLoS One, 3, pp.e2142~ (2008)
  130. Martin-Medina A, "Increased extracellular vesicles mediate WNT5A signaling in idiopathic pulmonary fibrosis", Am J Respir Crit Care Med, 198, pp.1527~1538 (2018)
  131. Serafino A, "Targeting the Wnt", β-catenin pathway in neurodegenerative diseases : recent approaches and current challenges, 2020, pp.15, 803~822
  132. Wang Q, "Activation of Wnt", β-catenin pathway mitigates blood-brain barrier dysfunction in Alzheimer’s disease, 2022, pp.145, 4474~4488
  133. Thenappan T, "Pulmonary arterial hypertension : pathogenesis and clinical management", BMJ, 360, pp.j5492~ (2018)
  134. Humbert M, "2022 ESC", ERS Guidelines for the diagnosis and treatment of pulmonary hypertension, 2022, pp.43, 3618~3731
  135. Roy B, "Brain structural changes in patients with pulmonary arterial hypertension", J Neuroimaging, 31, pp.524~531 (2021)
  136. Malenfant S, "Compromised cerebrovascular regulation and cerebral oxygenation in pulmonary arterial hypertension", J Am Heart Assoc, 6, pp.e006126~ (2017)
  137. Adir Y, "Sleep-related breathing disorders and pulmonary hypertension", Eur Respir J, 57, pp.2002258~ (2021)
  138. Giaid A, "Expression of endothelin-1 in the lungs of patients with pulmonary hypertension", N Engl J Med, 328, pp.1732~1739 (1993)
  139. Shao D, "The role of endothelin-1 in the pathogenesis of pulmonary arterial hypertension", Pharmacol Res, 63, pp.504~511 (2011)
  140. Chester AH, "The role of endothelin-1 in pulmonary arterial hypertension", Glob Cardiol Sci Pract, 2014, pp.62~78 (2014)
  141. Rubin LJ, "Bosentan therapy for pulmonary arterial hypertension", N Engl J Med, 346, pp.896~903 (2002)
  142. Sarji S, "Pulmonary hypertension is associated with white matter and microvascular changes in the brain", Am J Respir Crit Care Med, 195, pp.A4201~ (2017)
  143. Sharma RK, "Involvement of neuroinflammation in the pathogenesis of monocrotaline-induced pulmonary hypertension", Hypertension, 71, pp.1156~1163 (2018)
  144. Ursell LK, "Defining the human microbiome", Nutr Rev, 70(Suppl 1), pp.S38~S44 (2012)
  145. Gebrayel P, "Microbiota medicine : towards clinical revolution", J Transl Med, 20, pp.111~ (2022)
  146. Zhu M, "Gut microbiota : a novel therapeutic target for Parkinson’s disease", Front Immunol, 13, pp.937555~ (2022)
  147. Thirion F, "The gut microbiota in multiple sclerosis varies with disease activity", Genome Med, 15, pp.1~ (2023)
  148. Taniya MA, "Role of gut microbiome in autism spectrum disorder and its therapeutic regulation", Front Cell Infect Microbiol, 12, pp.915701~ (2022)
  149. Fan Y, "Gut microbiota in human metabolic health and disease", Nat Rev Microbiol, 19, pp.55~71 (2021)
  150. Dickson RP, "The microbiome and the respiratory tract", Annu Rev Physiol, 78, pp.481~504 (2016)
  151. Yildiz S, "Respiratory tissue-associated commensal bacteria offer therapeutic potential against pneumococcal colonization", eLife, 9, pp.e53581~ (2020)
  152. Zhang D, "The cross-talk between gut microbiota and lungs in common lung diseases", Front Microbiol, 11, pp.301~ (2020)
  153. Yang D, "The impact of lung microbiota dysbiosis on inflammation", Immunology, 159, pp.156~166 (2020)
  154. Yang D, "Dysregulated lung commensal bacteria drive interleukin-17B production to promote pulmonary fibrosis through their outer membrane vesicles", Immunity, 50, pp.692~706 (2019)
  155. Jin C, "Commensal microbiota promote lung cancer development via γδ t cells", Cell, 176, pp.998~1013 (2019)
  156. Hosang L, "The lung microbiome regulates brain autoimmunity", Nature, 603, pp.138~144 (2022)
  157. Hayer SS, "Antibiotic-induced gut dysbiosis and cognitive, emotional, and behavioral changes in rodents : a systematic review and meta-analysis", Front Neurosci, 17, pp.1237177~ (2023)
  158. Sparks Stein P, "Serum antibodies to periodontal pathogens are a risk factor for Alzheimer’s disease", Alzheimers Dement, 8, pp.196~203 (2012)
  159. Vogt NM, "Gut microbiome alterations in Alzheimer’s disease", Sci Rep, 7, pp.13537~ (2017)
  160. Cattaneo A, "Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly", Neurobiol Aging, 49, pp.60~68 (2017)
  161. Sikkema L, "An integrated cell atlas of the lung in health and disease", Nat Med, 29, pp.1563~1577 (2023)
  162. Elmentaite R, "Cells of the human intestinal tract mapped across space and time", Nature, 597, pp.250~255 (2021)
  163. Melo-González F, "Distal consequences of mucosal infections in intestinal and lung inflammation", Front Immunol, 13, pp.877533~ (2022)
  164. Bery AI, "Role of tertiary lymphoid organs in the regulation of immune responses in the periphery", Cell Mol Life Sci, 79, pp.359~ (2022)
  165. Bertrand Y, "IgA-producing B cells in lung homeostasis and disease", Front Immunol, 14, pp.1117749~ (2023)
  166. Allie SR, "Resident memory B cells", Viral Immunol, 33, pp.282~293 (2020)
  167. Xie L, "Analysis of lung microbiome in COVID-19 patients during time of hospitalization", Pathogens, 12, pp.944~ (2023)
  168. Karvela A, "Lung microbiome : an emerging player in lung cancer pathogenesis and progression", Clin Transl Oncol, 25, pp.2365~2372 (2023)
  169. Li R, "Lung microbiome : new insights into the pathogenesis of respiratory diseases", Signal Transduct Target Ther, 9, pp.19~ (2024)
  170. Strandwitz P, "GABA-modulating bacteria of the human gut microbiota", Nat Microbiol, 4, pp.396~403 (2019)
  171. Wu C, "GABA receptors in brain development, function, and injury", Metab Brain Dis, 30, pp.367~379 (2015)
  172. Guyenet PG, "Regulation of breathing and autonomic outflows by chemoreceptors", Compr Physiol, 4, pp.1511~1562 (2014)
  173. Frazier DT, "Role of phrenic nerve afferents in the control of breathing", J Appl Physiol, 70, pp.491~496 (1991)
  174. Pacia EB, "Assessment of diaphragm function", Chest Surg Clin N Am, 8, pp.225~236 (1998)
  175. Guyenet PG, "Neural structures that mediate sympathoexcitation during hypoxia", Respir Physiol, 121, pp.147~162 (2000)
  176. Bongianni F, "Reciprocal connections between rostral ventrolateral medulla and inspiration-related medullary areas in the cat", Brain Res, 565, pp.171~174 (1991)
  177. Chacón-Aponte AA, "Brain-lung interaction : a vicious cycle in traumatic brain injury", Acute Crit Care, 37, pp.35~44 (2022)
  178. Crotty Alexander LE, "Myeloid cell HIF-1α regulates asthma airway resistance and eosinophil function", J Mol Med(Berl), 91, pp.637~644 (2013)
  179. Chang MC, "The effectiveness of nonsteroidal anti-inflammatory drugs and acetaminophen in reduce the risk of amyotrophic lateral sclerosis? A meta-analysis", Sci Rep, 10, pp.14759~ (2020)
  180. Enaud R, "The gut-lung axis in health and respiratory diseases : A place for inter-organ and inter-kingdom crosstalks", Front Cell Infect Microbiol, 10, pp.9~ (2020)
  181. Carabotti M, "The gut-brain axis : interactions between enteric microbiota, central and enteric nervous systems", Ann Gastroenterol, 28, pp.203~209 (2015)
  182. Engevik MA, "Microbial metabolic capacity for intestinal folate production and modulation of host folate receptors", Front Microbiol, 10, pp.2305~ (2019)
  183. Mazumder MH, "Lung-gut axis of microbiome alterations following co-exposure to ultrafine carbon black and ozone", Part Fibre Toxicol, 20, pp.15~ (2023)
  184. Sencio V, "The lung-gut axis during viral respiratory infections : the impact of gut dysbiosis on secondary disease outcomes", Mucosal Immunol, 14, pp.296~304 (2021)

관련 논문AI추천

이 간행물의 다른 논문 (7건)